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Kansl2 KAT8 regulatory NSL complex subunit 2 [ Mus musculus (house mouse) ]

Gene ID: 69612, updated on 2-Nov-2024

Summary

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Official Symbol
Kansl2provided by MGI
Official Full Name
KAT8 regulatory NSL complex subunit 2provided by MGI
Primary source
MGI:MGI:1916862
See related
Ensembl:ENSMUSG00000022992 AllianceGenome:MGI:1916862
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B930009D17; 2310037I24Rik
Summary
Predicted to be involved in chromatin organization. Part of NSL complex. Is active in mitochondrion. Is expressed in nervous system and retina nuclear layer. Orthologous to human KANSL2 (KAT8 regulatory NSL complex subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 25.7), CNS E14 (RPKM 22.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Kansl2 in Genome Data Viewer
Location:
15 F1; 15 54.52 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (98415539..98432649, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (98517658..98534770, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8611 Neighboring gene lactalbumin, alpha Neighboring gene olfactory receptor 278, pseudogene 1 Neighboring gene olfactory receptor family 11 subfamily M member 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:98341916-98342069 Neighboring gene STARR-seq mESC enhancer starr_39662 Neighboring gene small nucleolar RNA, H/ACA box 34 Neighboring gene microRNA 1291 Neighboring gene STARR-positive B cell enhancer ABC_E946 Neighboring gene small nucleolar RNA, H/ACA box 2B Neighboring gene STARR-seq mESC enhancer starr_39663 Neighboring gene cyclin T1 Neighboring gene RIKEN cDNA 9330020H09 gene Neighboring gene STARR-positive B cell enhancer ABC_E1917 Neighboring gene sperm microtubule inner protein 11 Neighboring gene adenylate cyclase 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Temporal expression of MOF acetyltransferase primes transcription factor networks for erythroid fate. Pessoa Rodrigues C, et al. Sci Adv, 2020 May. PMID 32671208, Free PMC Article
  2. Evolutionary conserved NSL complex/BRD4 axis controls transcription activation via histone acetylation. Gaub A, et al. Nat Commun, 2020 May 7. PMID 32382029, Free PMC Article
  3. The NSL complex maintains nuclear architecture stability via lamin A/C acetylation. Karoutas A, et al. Nat Cell Biol, 2019 Oct. PMID 31576060
  4. COX17 acetylation via MOF-KANSL complex promotes mitochondrial integrity and function. Guhathakurta S, et al. Nat Metab, 2023 Nov. PMID 37813994, Free PMC Article
  5. Neural metabolic imbalance induced by MOF dysfunction triggers pericyte activation and breakdown of vasculature. Sheikh BN, et al. Nat Cell Biol, 2020 Jul. PMID 32541879

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC101985, MGC102368

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of NSL complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NSL complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of NSL complex ISO
Inferred from Sequence Orthology
more info
  
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
part_of histone acetyltransferase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
KAT8 regulatory NSL complex subunit 2
Names
NSL complex protein NSL2
non-specific lethal 2 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289437.1 → NP_001276366.1  KAT8 regulatory NSL complex subunit 2 isoform b

    See identical proteins and their annotated locations for NP_001276366.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AK162714, BC083325, BI134551, CJ059354
    Consensus CDS
    CCDS88832.1
    UniProtKB/TrEMBL
    F8WJE3
    Related
    ENSMUSP00000112101.4, ENSMUST00000116400.4
    Conserved Domains (1) summary
    pfam13891
    Location:28 → 92
    zf-C3Hc3H; Potential DNA-binding domain

  2. NM_001289438.1 → NP_001276367.1  KAT8 regulatory NSL complex subunit 2 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice junction at the 5' end of a coding exon compared to variant 1. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC138221, AK046649, AK162714, BI134551, CJ059354
    UniProtKB/Swiss-Prot
    Q8BQR4
    Conserved Domains (1) summary
    pfam13891
    Location:173 → 230
    zf-C3Hc3H; Potential DNA-binding domain

  3. NM_001289439.1 → NP_001276368.1  KAT8 regulatory NSL complex subunit 2 isoform d

    See identical proteins and their annotated locations for NP_001276368.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 4 and 5 both encode the same isoform (d).
    Source sequence(s)
    AK046649, AK162714, AK168499, BI134551, CJ059354
    UniProtKB/Swiss-Prot
    Q8BQR4
    Conserved Domains (1) summary
    pfam13891
    Location:112 → 169
    zf-C3Hc3H; Potential DNA-binding domain

  4. NM_001289440.1 → NP_001276369.1  KAT8 regulatory NSL complex subunit 2 isoform d

    See identical proteins and their annotated locations for NP_001276369.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and lacks an alternate exon compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 4 and 5 both encode the same isoform (d).
    Source sequence(s)
    AK046649, AK162714, AK168499, BI134551, CJ059354
    UniProtKB/Swiss-Prot
    Q8BQR4
    Conserved Domains (1) summary
    pfam13891
    Location:112 → 169
    zf-C3Hc3H; Potential DNA-binding domain

  5. NM_001359827.1 → NP_001346756.1  KAT8 regulatory NSL complex subunit 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Both variants 1 and 6 encode the same protein.
    Source sequence(s)
    AC138221
    Consensus CDS
    CCDS37190.1
    UniProtKB/Swiss-Prot
    Q3TJH8, Q569W7, Q5XJH6, Q8BQR4, Q8C8F3, Q8C8I6, Q8CEY3, Q99LE5
    UniProtKB/TrEMBL
    F8WJE3
    Conserved Domains (1) summary
    pfam13891
    Location:28 → 92
    zf-C3Hc3H; Potential DNA-binding domain

  6. NM_133714.5 → NP_598475.2  KAT8 regulatory NSL complex subunit 2 isoform a

    See identical proteins and their annotated locations for NP_598475.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Both variants 1 and 6 encode the same protein.
    Source sequence(s)
    AK046649, AK162714, BI134551, CJ059354
    Consensus CDS
    CCDS37190.1
    UniProtKB/Swiss-Prot
    Q3TJH8, Q569W7, Q5XJH6, Q8BQR4, Q8C8F3, Q8C8I6, Q8CEY3, Q99LE5
    UniProtKB/TrEMBL
    F8WJE3
    Related
    ENSMUSP00000155089.2, ENSMUST00000230542.2
    Conserved Domains (1) summary
    pfam13891
    Location:28 → 92
    zf-C3Hc3H; Potential DNA-binding domain

RNA

  1. NR_153345.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 3' exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC138221, AEKQ02119723

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    98415539..98432649 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017316743.3 → XP_017172232.1  KAT8 regulatory NSL complex subunit 2 isoform X4

    Conserved Domains (1) summary
    pfam13891
    Location:112 → 169
    zf-C3Hc3H; Potential DNA-binding domain

  2. XM_036159568.1 → XP_036015461.1  KAT8 regulatory NSL complex subunit 2 isoform X2

    UniProtKB/TrEMBL
    F8WJE3
    Conserved Domains (1) summary
    pfam13891
    Location:28 → 92
    zf-C3Hc3H; Potential DNA-binding domain

  3. XM_030248754.2 → XP_030104614.1  KAT8 regulatory NSL complex subunit 2 isoform X3

    Conserved Domains (1) summary
    pfam13891
    Location:173 → 230
    zf-C3Hc3H; Potential DNA-binding domain

  4. XM_030248755.2 → XP_030104615.1  KAT8 regulatory NSL complex subunit 2 isoform X4

    Conserved Domains (1) summary
    pfam13891
    Location:112 → 169
    zf-C3Hc3H; Potential DNA-binding domain

  5. XM_036159569.1 → XP_036015462.1  KAT8 regulatory NSL complex subunit 2 isoform X2

    UniProtKB/TrEMBL
    F8WJE3
    Conserved Domains (1) summary
    pfam13891
    Location:28 → 92
    zf-C3Hc3H; Potential DNA-binding domain

  6. XM_030248753.2 → XP_030104613.1  KAT8 regulatory NSL complex subunit 2 isoform X1

    UniProtKB/TrEMBL
    F8WJE3
    Conserved Domains (1) summary
    pfam13891
    Location:28 → 92
    zf-C3Hc3H; Potential DNA-binding domain

RNA

  1. XR_384040.5 RNA Sequence

  2. XR_004938869.1 RNA Sequence

  3. XR_003951435.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BQR4.1 GenPept UniProtKB/Swiss-Prot:Q8BQR4

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