SIX1 SIX homeobox 1 [Gallus gallus (chicken)] - Gene

Summary

Symbol: SIX1provided by CGNC
Full Name: SIX homeobox 1provided by CGNC
Primary source: CGNC:54357
See related: Ensembl:ENSGALG00010017933
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	5	NC_052536.1 (53908593..53911077)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	5	NC_052577.1 (53896899..53899386)

Chromosome 5 - NC_052536.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Six1E1 and Six1E2, act synergistically in craniofacial development
Title: Cis-control of Six1 expression in neural crest cells during craniofacial development.
Activation of Six1 Expression in Vertebrate Sensory Neurons.
Title: Activation of Six1 Expression in Vertebrate Sensory Neurons.
Combinatorial activity of Six1, Six2, and Six4 genes in cephalic neural crest cells controls craniofacial and brain development.
Title: Combinatorial activity of Six1-2-4 genes in cephalic neural crest cells controls craniofacial and brain development.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed
part_of transcription regulator complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: homeobox protein SIX1

Names: sine oculis homeobox homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001044685.2 → NP_001038150.1 homeobox protein SIX1

See identical proteins and their annotated locations for NP_001038150.1

Status: VALIDATED

Source sequence(s)

JAENSK010000215

UniProtKB/TrEMBL

Q3C2H5

Related

ENSGALP00010025767.1, ENSGALT00010043352.1

Conserved Domains (2) summary

cd00086
Location:129 → 180

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

pfam16878
Location:9 → 118

SIX1_SD; Transcriptional regulator, SIX1, N-terminal SD domain