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Hsd17b14 hydroxysteroid (17-beta) dehydrogenase 14 [ Rattus norvegicus (Norway rat) ]

Gene ID: 691018, updated on 2-Nov-2024

Summary

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Official Symbol
Hsd17b14provided by RGD
Official Full Name
hydroxysteroid (17-beta) dehydrogenase 14provided by RGD
Primary source
RGD:1588673
See related
EnsemblRapid:ENSRNOG00000020949 AllianceGenome:RGD:1588673
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Dhrs10
Summary
Predicted to enable estradiol 17-beta-dehydrogenase [NAD(P)+] activity; identical protein binding activity; and testosterone 17-beta-dehydrogenase (NADP+) activity. Predicted to be involved in steroid catabolic process. Predicted to be active in cytosol. Orthologous to human HSD17B14 (hydroxysteroid 17-beta dehydrogenase 14). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 35.0), Liver (RPKM 19.8) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Hsd17b14 in Genome Data Viewer
Location:
1q22
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (105165695..105176045)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (96029224..96039577)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (101541266..101551059)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory subunit 15A Neighboring gene pleckstrin homology domain containing A4 Neighboring gene transfer RNA serine (anticodon AGA) 17 Neighboring gene uncharacterized LOC120097182 Neighboring gene uncharacterized LOC102556190 Neighboring gene branched chain amino acid transaminase 2 Neighboring gene uncharacterized LOC134485119 Neighboring gene transfer RNA proline (anticodon GGG)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Structural and biochemical characterization of human orphan DHRS10 reveals a novel cytosolic enzyme with steroid dehydrogenase activity. Lukacik P, et al. Biochem J, 2007 Mar 15. PMID 17067289, Free PMC Article
  2. Pooled-matrix protein interaction screens using Barcode Fusion Genetics. Yachie N, et al. Mol Syst Biol, 2016 Apr 22. PMID 27107012, Free PMC Article
  3. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. Fragoza R, et al. Nat Commun, 2019 Sep 12. PMID 31515488, Free PMC Article
  4. Towards a proteome-scale map of the human protein-protein interaction network. Rual JF, et al. Nature, 2005 Oct 20. PMID 16189514
  5. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables testosterone 17-beta-dehydrogenase (NADP+) activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in steroid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in steroid catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
17-beta-hydroxysteroid dehydrogenase 14
Names
dehydrogenase/reductase (SDR family) member 10
NP_001178040.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191111.2 → NP_001178040.1  17-beta-hydroxysteroid dehydrogenase 14

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I6G8X8, A0A8I6GJ95
    Related
    ENSRNOP00000090949.1, ENSRNOT00000103712.2
    Conserved Domains (1) summary
    cl21454
    Location:1 → 256
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    105165695..105176045
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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