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Polr2e RNA polymerase II, I and III subunit E [ Rattus norvegicus (Norway rat) ]

Gene ID: 690966, updated on 2-Nov-2024

Summary

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Official Symbol
Polr2eprovided by RGD
Official Full Name
RNA polymerase II, I and III subunit Eprovided by RGD
Primary source
RGD:1589817
See related
EnsemblRapid:ENSRNOG00000013545 AllianceGenome:RGD:1589817
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA binding activity and DNA-directed 5'-3' RNA polymerase activity. Predicted to contribute to RNA polymerase I activity; RNA polymerase II activity; and RNA polymerase III activity. Predicted to be involved in tRNA transcription by RNA polymerase III; transcription by RNA polymerase II; and transcription elongation by RNA polymerase I. Predicted to be located in nucleoplasm. Predicted to be part of RPAP3/R2TP/prefoldin-like complex and nuclear DNA-directed RNA polymerase complex. Orthologous to human POLR2E (RNA polymerase II, I and III subunit E). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 343.5), Kidney (RPKM 301.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Polr2e in Genome Data Viewer
Location:
7q11
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (10317332..10321280)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (9666695..9670638)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (12532785..12536797)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene glutathione peroxidase 4 Neighboring gene uncharacterized LOC134479812 Neighboring gene Rho GTPase activating protein 45 Neighboring gene ATP binding cassette subfamily A member 7 Neighboring gene uncharacterized LOC134479813

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Conservation between the RNA polymerase I, II, and III transcription initiation machineries. Vannini A, et al. Mol Cell, 2012 Feb 24. PMID 22365827
  2. Structure and function of RNA polymerase II elongation factor ELL. Identification of two overlapping ELL functional domains that govern its interaction with polymerase and the ternary elongation complex. Shilatifard A, et al. J Biol Chem, 1997 Aug 29. PMID 9268387
  3. TFIIB-related factors in RNA polymerase I transcription. Knutson BA, et al. Biochim Biophys Acta, 2013 Mar-Apr. PMID 22960599, Free PMC Article
  4. Cell growth- and differentiation-dependent regulation of RNA polymerase III transcription. Dumay-Odelot H, et al. Cell Cycle, 2010 Sep 15. PMID 20890107, Free PMC Article
  5. RNA polymerase I activity is regulated at multiple steps in the transcription cycle: recent insights into factors that influence transcription elongation. Schneider DA. Gene, 2012 Feb 10. PMID 21893173, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-directed 5'-3' RNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to RNA polymerase I activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to RNA polymerase II activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to RNA polymerase III activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in tRNA transcription by RNA polymerase III IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in transcription elongation by RNA polymerase I IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of RNA polymerase I complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase I complex IEA
Inferred from Electronic Annotation
more info
  
part_of RNA polymerase I complex ISO
Inferred from Sequence Orthology
more info
  
part_of RNA polymerase II, core complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase II, core complex IEA
Inferred from Electronic Annotation
more info
  
part_of RNA polymerase II, core complex ISO
Inferred from Sequence Orthology
more info
  
part_of RNA polymerase II, core complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of RNA polymerase III complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase III complex IEA
Inferred from Electronic Annotation
more info
  
part_of RNA polymerase III complex ISO
Inferred from Sequence Orthology
more info
  
part_of RPAP3/R2TP/prefoldin-like complex IEA
Inferred from Electronic Annotation
more info
  
part_of RPAP3/R2TP/prefoldin-like complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
DNA-directed RNA polymerases I, II, and III subunit RPABC1
Names
DNA-directed RNA polymerase II subunit E
RNA polymerase II subunit E
RNA polymerases I, II, and III subunit ABC1
RPB5 homolog
polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
polymerase (RNA) II subunit E
NP_001103084.1
XP_006241071.1
XP_006241072.1
XP_006241073.1
XP_038935858.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109614.1 → NP_001103084.1  DNA-directed RNA polymerases I, II, and III subunit RPABC1

    See identical proteins and their annotated locations for NP_001103084.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474029
    UniProtKB/Swiss-Prot
    B0BNE2
    UniProtKB/TrEMBL
    A0A1W2Q690, A6K8S4
    Conserved Domains (1) summary
    PLN03111
    Location:1 → 209
    PLN03111; DNA-directed RNA polymerase II subunit family protein; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    10317332..10321280
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039079930.2 → XP_038935858.1  DNA-directed RNA polymerases I, II, and III subunit RPABC1 isoform X3

    UniProtKB/Swiss-Prot
    B0BNE2
    UniProtKB/TrEMBL
    A0A1W2Q690, A6K8S4
    Related
    ENSRNOP00000076239.1, ENSRNOT00000093413.3
    Conserved Domains (1) summary
    PLN03111
    Location:1 → 209
    PLN03111; DNA-directed RNA polymerase II subunit family protein; Provisional

  2. XM_006241009.5 → XP_006241071.1  DNA-directed RNA polymerases I, II, and III subunit RPABC1 isoform X1

    See identical proteins and their annotated locations for XP_006241071.1

    UniProtKB/TrEMBL
    A0A8L2Q9B5, A6K8S6
    Conserved Domains (3) summary
    PLN03111
    Location:1 → 190
    PLN03111; DNA-directed RNA polymerase II subunit family protein; Provisional
    pfam01191
    Location:138 → 190
    RNA_pol_Rpb5_C; RNA polymerase Rpb5, C-terminal domain
    pfam03871
    Location:4 → 92
    RNA_pol_Rpb5_N; RNA polymerase Rpb5, N-terminal domain

  3. XM_006241011.3 → XP_006241073.1  DNA-directed RNA polymerases I, II, and III subunit RPABC1 isoform X4

    See identical proteins and their annotated locations for XP_006241073.1

    UniProtKB/TrEMBL
    A0A1W2Q690, A6K8S9
    Related
    ENSRNOP00000076166.3, ENSRNOT00000093599.3
    Conserved Domains (3) summary
    PLN03111
    Location:15 → 201
    PLN03111; DNA-directed RNA polymerase II subunit family protein; Provisional
    pfam01191
    Location:130 → 201
    RNA_pol_Rpb5_C; RNA polymerase Rpb5, C-terminal domain
    pfam03871
    Location:11 → 84
    RNA_pol_Rpb5_N; RNA polymerase Rpb5, N-terminal domain

  4. XM_006241010.3 → XP_006241072.1  DNA-directed RNA polymerases I, II, and III subunit RPABC1 isoform X2

    Conserved Domains (2) summary
    pfam01191
    Location:130 → 182
    RNA_pol_Rpb5_C; RNA polymerase Rpb5, C-terminal domain
    pfam03871
    Location:11 → 84
    RNA_pol_Rpb5_N; RNA polymerase Rpb5, N-terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B0BNE2.1 GenPept UniProtKB/Swiss-Prot:B0BNE2

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