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Thap7 THAP domain containing 7 [ Mus musculus (house mouse) ]

Gene ID: 69009, updated on 2-Nov-2024

Summary

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Official Symbol
Thap7provided by MGI
Official Full Name
THAP domain containing 7provided by MGI
Primary source
MGI:MGI:1916259
See related
Ensembl:ENSMUSG00000022760 AllianceGenome:MGI:1916259
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1810004B07Rik
Summary
Predicted to enable several functions, including C2H2 zinc finger domain binding activity; histone binding activity; and histone deacetylase binding activity. Predicted to be involved in chromatin organization and negative regulation of transcription by RNA polymerase II. Predicted to be located in chromatin; nuclear membrane; and nuclear speck. Predicted to be active in nucleus. Is expressed in central nervous system; early conceptus; heart; reproductive system; and urinary system. Orthologous to human THAP7 (THAP domain containing 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in ovary adult (RPKM 39.8), adrenal adult (RPKM 37.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Thap7 in Genome Data Viewer
Location:
16 A3; 16 10.86 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (17345823..17349975, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (17527959..17531151, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene apoptosis-inducing factor, mitochondrion-associated 3 Neighboring gene leucine-zipper-like transcriptional regulator, 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:17531169-17531278 Neighboring gene leucine rich repeat containing 74B Neighboring gene STARR-positive B cell enhancer ABC_E10890 Neighboring gene STARR-seq mESC enhancer starr_40257 Neighboring gene purinergic receptor P2X, ligand-gated ion channel, 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mouse and human CRKL is dosage sensitive for cardiac outflow tract formation. Racedo SE, et al. Am J Hum Genet, 2015 Feb 5. PMID 25658046, Free PMC Article
  2. Risk of meningomyelocele mediated by the common 22q11.2 deletion. Vong KI, et al. Science, 2024 May 3. PMID 38696583
  3. Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor. Pilot-Storck F, et al. Mol Cell Proteomics, 2010 Jul. PMID 20368287, Free PMC Article
  4. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article
  5. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables C2H2 zinc finger domain binding IEA
Inferred from Electronic Annotation
more info
  
enables C2H2 zinc finger domain binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables general transcription initiation factor binding IEA
Inferred from Electronic Annotation
more info
  
enables general transcription initiation factor binding ISO
Inferred from Sequence Orthology
more info
  
enables histone binding ISO
Inferred from Sequence Orthology
more info
  
enables histone deacetylase binding IEA
Inferred from Electronic Annotation
more info
  
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
  
enables histone reader activity IEA
Inferred from Electronic Annotation
more info
  
enables histone reader activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables lysine-acetylated histone binding IEA
Inferred from Electronic Annotation
more info
  
enables lysine-acetylated histone binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methylated histone binding IEA
Inferred from Electronic Annotation
more info
  
enables methylated histone binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphorylated histone binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphorylated histone binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription corepressor binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription corepressor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin organization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromatin IEA
Inferred from Electronic Annotation
more info
  
located_in chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
THAP domain-containing protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026909.2 → NP_081185.1  THAP domain-containing protein 7

    See identical proteins and their annotated locations for NP_081185.1

    Status: PROVISIONAL

    Source sequence(s)
    AC113006
    Consensus CDS
    CCDS28004.1
    UniProtKB/Swiss-Prot
    Q8VCZ3
    UniProtKB/TrEMBL
    Q3U3Q2
    Related
    ENSMUSP00000097701.4, ENSMUST00000100125.12
    Conserved Domains (2) summary
    smart00980
    Location:4 → 93
    THAP; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion
    PHA03247
    Location:111 → 221
    PHA03247; large tegument protein UL36; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    17345823..17349975 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246003.4 → XP_011244305.1  THAP domain-containing protein 7 isoform X4

    UniProtKB/TrEMBL
    A0A338P7J4

  2. XM_006522513.5 → XP_006522576.1  THAP domain-containing protein 7 isoform X3

    UniProtKB/TrEMBL
    Q3U3Q2
    Conserved Domains (1) summary
    PHA03247
    Location:59 → 169
    PHA03247; large tegument protein UL36; Provisional

  3. XM_030249261.2 → XP_030105121.1  THAP domain-containing protein 7 isoform X2

    UniProtKB/TrEMBL
    Q3U3Q2
    Conserved Domains (1) summary
    smart00980
    Location:4 → 74
    THAP; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion

  4. XM_036160107.1 → XP_036016000.1  THAP domain-containing protein 7 isoform X4

    UniProtKB/TrEMBL
    A0A338P7J4
    Related
    ENSMUSP00000156319.2, ENSMUST00000232041.2

  5. XM_006522511.5 → XP_006522574.1  THAP domain-containing protein 7 isoform X1

    See identical proteins and their annotated locations for XP_006522574.1

    UniProtKB/Swiss-Prot
    Q8VCZ3
    UniProtKB/TrEMBL
    Q3U3Q2
    Related
    ENSMUSP00000156168.2, ENSMUST00000231548.2
    Conserved Domains (2) summary
    smart00980
    Location:4 → 93
    THAP; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion
    PHA03247
    Location:111 → 221
    PHA03247; large tegument protein UL36; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VCZ3.1 GenPept UniProtKB/Swiss-Prot:Q8VCZ3

Gene LinkOut

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