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TACC1 transforming acidic coiled-coil containing protein 1 [ Homo sapiens (human) ]

Gene ID: 6867, updated on 3-Nov-2024

Summary

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Official Symbol
TACC1provided by HGNC
Official Full Name
transforming acidic coiled-coil containing protein 1provided by HGNC
Primary source
HGNC:HGNC:11522
See related
Ensembl:ENSG00000147526 MIM:605301; AllianceGenome:HGNC:11522
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Ga55
Summary
This locus may represent a breast cancer candidate gene. It is located close to FGFR1 on a region of chromosome 8 that is amplified in some breast cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017]
Expression
Ubiquitous expression in fat (RPKM 59.1), endometrium (RPKM 38.3) and 24 other tissues See more
Orthologs
mouse all
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Genomic context

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See TACC1 in Genome Data Viewer
Location:
8p11.22
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (38728582..38853028)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (39005551..39130036)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (38586100..38710546)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ring finger protein 5 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19131 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38508629-38509230 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38508026-38508628 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:38546721-38547014 Neighboring gene uncharacterized LOC124901936 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:38558842-38559342 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19132 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38577151-38577672 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27255 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27256 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:38591927-38592426 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:38593007-38593506 Neighboring gene Sharpr-MPRA regulatory region 10821 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19133 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19134 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19135 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27257 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27258 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19136 Neighboring gene Sharpr-MPRA regulatory region 13542 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:38654374-38654912 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27259 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27260 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27261 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27262 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:38664233-38664424 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38692400-38693183 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27263 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:38718798-38719298 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:38719299-38719799 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:38721554-38722054 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:38722055-38722555 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:38724712-38725911 Neighboring gene uncharacterized LOC124901937 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27265 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27266 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19137 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19138 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27267 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38771665-38772346 Neighboring gene pleckstrin homology domain containing A2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38793869-38794549 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38794550-38795229 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27269 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27270 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19139 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27271 Neighboring gene Sharpr-MPRA regulatory region 15086 Neighboring gene HtrA serine peptidase 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Altered splicing pattern of TACC1 mRNA in gastric cancer. Line A, et al. Cancer Genet Cytogenet, 2002 Nov. PMID 12547166
  2. Temporal and spatial expression of TACC1 in the mouse and human. Lauffart B, et al. Dev Dyn, 2006 Jun. PMID 16496324
  3. Aurora-C interacts with and phosphorylates the transforming acidic coiled-coil 1 protein. Gabillard JC, et al. Biochem Biophys Res Commun, 2011 May 20. PMID 21531210
  4. Prognosis significance of HER2 status and TACC1 expression in patients with gastric carcinoma. Lv J, et al. Med Oncol, 2014 Nov. PMID 25297519
  5. Cloning of TACC1, an embryonically expressed, potentially transforming coiled coil containing gene, from the 8p11 breast cancer amplicon. Still IH, et al. Oncogene, 1999 Jul 8. PMID 10435627

See all (85) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LINC01140 inhibits nonsmall cell lung cancer progression and cisplatin resistance through the miR-4742-5p/TACC1 axis.
    Title: LINC01140 inhibits nonsmall cell lung cancer progression and cisplatin resistance through the miR-4742-5p/TACC1 axis.
  2. Neurofibrosarcoma Revisited: An Institutional Case Series of Uterine Sarcomas Harboring Kinase-related Fusions With Report of a Novel FGFR1-TACC1 Fusion.
    Title: Neurofibrosarcoma Revisited: An Institutional Case Series of Uterine Sarcomas Harboring Kinase-related Fusions With Report of a Novel FGFR1-TACC1 Fusion.
  3. The correlation between TACC1 expression and HER-2-positive status indicates synergistic regulation of these two prognostic markers in gastric carcinoma patients.
    Title: Prognosis significance of HER2 status and TACC1 expression in patients with gastric carcinoma.
  4. TFF3 and TACC1 over-expression in epithelial cells of surgically resected gastric cancer tissues was an independent predictor of short survival in gastric cancer patients.
    Title: Impact of NPM, TFF3 and TACC1 on the prognosis of patients with primary gastric cancer.
  5. These findings provide proof and the foundation for the molecular and biological relationships of ErbB-2 and TACC1 in breast cancer.
    Title: Efficient downregulation of ErbB-2 induces TACC1 upregulation in breast cancer cell lines.
  6. study reports that a small subset of glioblastoma multiforme tumors harbors oncogenic chromosomal translocations that fuse in-frame the tyrosine kinase coding domains of fibroblast growth factor receptor genes(FGFR1 or FGFR3) to the transforming acidic coiled-coil coding domains of TACC1 or TACC3; the FGFR-TACC fusion protein displays oncogenic activity
    Title: Transforming fusions of FGFR and TACC genes in human glioblastoma.
  7. the study demonstrated that TACC1 localizes at the midbody during cytokinesis and interacts with and is a substrate of Aurora-C, which warrant further investigation in order to elucidate the functional significance of this interaction.
    Title: Aurora-C interacts with and phosphorylates the transforming acidic coiled-coil 1 protein.
  8. Observational study of gene-disease association. (HuGE Navigator)
    Title: A large-scale candidate gene association study of age at menarche and age at natural menopause.
  9. TACC1 depletion in the cell led to decreased RARalpha and TRalpha ligand-dependent transcriptional activity and to delocalization of TR from the nucleus to the cytoplasm.
    Title: The transforming acidic coiled coil (TACC1) protein modulates the transcriptional activity of the nuclear receptors TR and RAR.
  10. TACC1 and a three-gene expression signature (TACC1, NOV, and PTTG1) were identified as independent prognostic markers.
    Title: Identification of TACC1, NOV, and PTTG1 as new candidate genes associated with endocrine therapy resistance in breast cancer.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ42304, KIAA1103, DKFZp686K18126

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables nuclear estrogen receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nuclear glucocorticoid receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nuclear receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nuclear receptor coactivator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables nuclear retinoic acid receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nuclear retinoid X receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nuclear thyroid hormone receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables peroxisome proliferator activated receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cerebral cortex development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle organization IEA
Inferred from Electronic Annotation
more info
  
involved_in nuclear migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in midbody IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transforming acidic coiled-coil-containing protein 1
Names
gastric cancer antigen Ga55
taxin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122824.2 → NP_001116296.1  transforming acidic coiled-coil-containing protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001116296.1

    Status: REVIEWED

    Source sequence(s)
    AY139007, AY177411, DB084271
    Consensus CDS
    CCDS47845.1
    UniProtKB/Swiss-Prot
    O75410
    Related
    ENSP00000276520.8, ENST00000276520.12
    Conserved Domains (1) summary
    pfam05010
    Location:189 → 388
    TACC; Transforming acidic coiled-coil-containing protein (TACC)

  2. NM_001146216.3 → NP_001139688.1  transforming acidic coiled-coil-containing protein 1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), as well as variants 16-18, encodes isoform 3.
    Source sequence(s)
    AB029026, AC067817, AY072876, BX647696
    Consensus CDS
    CCDS55224.1
    UniProtKB/TrEMBL
    B4DHF7
    Related
    ENSP00000428450.1, ENST00000520615.5
    Conserved Domains (1) summary
    pfam05010
    Location:404 → 603
    TACC; Transforming acidic coiled-coil-containing protein (TACC)

  3. NM_001330521.2 → NP_001317450.1  transforming acidic coiled-coil-containing protein 1 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), as well as variants 22-25, encodes isoform 4.
    Source sequence(s)
    AC067817, AI129797, BQ001033, DA152500, DA553264
    Consensus CDS
    CCDS83284.1
    UniProtKB/TrEMBL
    B4DH49, E7EVI4
    Conserved Domains (1) summary
    pfam05010
    Location:375 → 574
    TACC; Transforming acidic coiled-coil-containing protein (TACC)

  4. NM_001352778.2 → NP_001339707.1  transforming acidic coiled-coil-containing protein 1 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) encodes the longest isoform (5).
    Source sequence(s)
    AC016813, AC067817
    Conserved Domains (1) summary
    pfam05010
    Location:615 → 814
    TACC; Transforming acidic coiled-coil-containing protein (TACC)

  5. NM_001352779.2 → NP_001339708.1  transforming acidic coiled-coil-containing protein 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC067817
    Conserved Domains (1) summary
    pfam05010
    Location:611 → 810
    TACC; Transforming acidic coiled-coil-containing protein (TACC)

  6. NM_001352780.2 → NP_001339709.1  transforming acidic coiled-coil-containing protein 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC016813, AC067817
    Conserved Domains (1) summary
    pfam05010
    Location:586 → 785
    TACC; Transforming acidic coiled-coil-containing protein (TACC)

  7. NM_001352781.2 → NP_001339710.1  transforming acidic coiled-coil-containing protein 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC067817
    Conserved Domains (1) summary
    pfam05010
    Location:582 → 781
    TACC; Transforming acidic coiled-coil-containing protein (TACC)

  8. NM_001352782.2 → NP_001339711.1  transforming acidic coiled-coil-containing protein 1 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC016813, AC067817
    Conserved Domains (1) summary
    pfam05010
    Location:571 → 770
    TACC; Transforming acidic coiled-coil-containing protein (TACC)

  9. NM_001352783.2 → NP_001339712.1  transforming acidic coiled-coil-containing protein 1 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC067817
    Conserved Domains (1) summary
    pfam05010
    Location:570 → 769
    TACC; Transforming acidic coiled-coil-containing protein (TACC)

  10. NM_001352784.2 → NP_001339713.1  transforming acidic coiled-coil-containing protein 1 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC016813, AC067817
    Consensus CDS
    CCDS94286.1
    UniProtKB/TrEMBL
    E5RFM9
    Related
    ENSP00000430355.2, ENST00000522904.6
    Conserved Domains (1) summary
    pfam05010
    Location:542 → 741
    TACC; Transforming acidic coiled-coil-containing protein (TACC)

  11. NM_001352785.2 → NP_001339714.1  transforming acidic coiled-coil-containing protein 1 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC016813, AC067817
    Conserved Domains (1) summary
    pfam05010
    Location:534 → 733
    TACC; Transforming acidic coiled-coil-containing protein (TACC)

  12. NM_001352786.2 → NP_001339715.1  transforming acidic coiled-coil-containing protein 1 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC016813, AC067817
    Consensus CDS
    CCDS87601.1
    Related
    ENSP00000428706.1, ENST00000518415.5
    Conserved Domains (1) summary
    pfam05010
    Location:525 → 724
    TACC; Transforming acidic coiled-coil-containing protein (TACC)

  13. NM_001352787.2 → NP_001339716.1  transforming acidic coiled-coil-containing protein 1 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC016813, AC067817
    Conserved Domains (1) summary
    pfam05010
    Location:563 → 762
    TACC; Transforming acidic coiled-coil-containing protein (TACC)

  14. NM_001352788.2 → NP_001339717.1  transforming acidic coiled-coil-containing protein 1 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC016813, AC067817
    UniProtKB/TrEMBL
    B4DHF7
    Conserved Domains (1) summary
    pfam05010
    Location:416 → 615
    TACC; Transforming acidic coiled-coil-containing protein (TACC)

  15. NM_001352789.2 → NP_001339718.1  transforming acidic coiled-coil-containing protein 1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), as well as variants 3, 17, and 18, encodes isoform 3.
    Source sequence(s)
    AC016813, AC067817
    Consensus CDS
    CCDS55224.1
    UniProtKB/TrEMBL
    B4DHF7
    Conserved Domains (1) summary
    pfam05010
    Location:404 → 603
    TACC; Transforming acidic coiled-coil-containing protein (TACC)

  16. NM_001352790.2 → NP_001339719.1  transforming acidic coiled-coil-containing protein 1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17), as well as variants 3, 16, and 18, encodes isoform 3.
    Source sequence(s)
    AC016813, AC067817
    Consensus CDS
    CCDS55224.1
    UniProtKB/TrEMBL
    B4DHF7
    Conserved Domains (1) summary
    pfam05010
    Location:404 → 603
    TACC; Transforming acidic coiled-coil-containing protein (TACC)

  17. NM_001352791.1 → NP_001339720.1  transforming acidic coiled-coil-containing protein 1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18), as well as variants 3, 16, and 17, encodes isoform 3.
    Source sequence(s)
    AC067817
    Consensus CDS
    CCDS55224.1
    UniProtKB/TrEMBL
    B4DHF7
    Conserved Domains (1) summary
    pfam05010
    Location:404 → 603
    TACC; Transforming acidic coiled-coil-containing protein (TACC)

  18. NM_001352792.2 → NP_001339721.1  transforming acidic coiled-coil-containing protein 1 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC016813, AC067817
    Consensus CDS
    CCDS87602.1
    UniProtKB/TrEMBL
    E7ET87, Q5HYH0
    Related
    ENSP00000428687.1, ENST00000519416.5
    Conserved Domains (1) summary
    pfam05010
    Location:403 → 602
    TACC; Transforming acidic coiled-coil-containing protein (TACC)

  19. NM_001352793.2 → NP_001339722.1  transforming acidic coiled-coil-containing protein 1 isoform 17

    Status: REVIEWED

    Description
    Transcript Variant: This variant (20), as well as variant 21, encodes isoform 17.
    Source sequence(s)
    AC016813, AC067817
    UniProtKB/TrEMBL
    B4DHF7
    Conserved Domains (1) summary
    pfam05010
    Location:404 → 602
    TACC; Transforming acidic coiled-coil-containing protein (TACC)

  20. NM_001352794.2 → NP_001339723.1  transforming acidic coiled-coil-containing protein 1 isoform 17

    Status: REVIEWED

    Description
    Transcript Variant: This variant (21), as well as variant 20, encodes isoform 17.
    Source sequence(s)
    AC016813, AC067817
    UniProtKB/TrEMBL
    B4DHF7
    Conserved Domains (1) summary
    pfam05010
    Location:404 → 602
    TACC; Transforming acidic coiled-coil-containing protein (TACC)

  21. NM_001352795.2 → NP_001339724.1  transforming acidic coiled-coil-containing protein 1 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (22), as well as variants 4 and 23-25, encodes isoform 4.
    Source sequence(s)
    AC016813, AC067817
    Consensus CDS
    CCDS83284.1
    UniProtKB/TrEMBL
    B4DH49, E7EVI4
    Conserved Domains (1) summary
    pfam05010
    Location:375 → 574
    TACC; Transforming acidic coiled-coil-containing protein (TACC)

  22. NM_001352796.2 → NP_001339725.1  transforming acidic coiled-coil-containing protein 1 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (23), as well as variants 4, 22, 24, and 25, encodes isoform 4.
    Source sequence(s)
    AC016813, AC067817
    Consensus CDS
    CCDS83284.1
    UniProtKB/TrEMBL
    B4DH49, E7EVI4
    Conserved Domains (1) summary
    pfam05010
    Location:375 → 574
    TACC; Transforming acidic coiled-coil-containing protein (TACC)

  23. NM_001352797.2 → NP_001339726.1  transforming acidic coiled-coil-containing protein 1 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (24), as well as variants 4, 22, 23, and 25, encodes isoform 4.
    Source sequence(s)
    AC016813, AC067817
    Consensus CDS
    CCDS83284.1
    UniProtKB/TrEMBL
    B4DH49, E7EVI4
    Conserved Domains (1) summary
    pfam05010
    Location:375 → 574
    TACC; Transforming acidic coiled-coil-containing protein (TACC)

  24. NM_001352798.1 → NP_001339727.1  transforming acidic coiled-coil-containing protein 1 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (25), as well as variants 4 and 22-24, encodes isoform 4.
    Source sequence(s)
    AC067817
    Consensus CDS
    CCDS83284.1
    UniProtKB/TrEMBL
    B4DH49, E7EVI4
    Related
    ENSP00000430959.1, ENST00000520973.5
    Conserved Domains (1) summary
    pfam05010
    Location:375 → 574
    TACC; Transforming acidic coiled-coil-containing protein (TACC)

  25. NM_001352799.2 → NP_001339728.1  transforming acidic coiled-coil-containing protein 1 isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC016813, AC067817
    UniProtKB/TrEMBL
    B4DH49
    Conserved Domains (1) summary
    pfam05010
    Location:375 → 573
    TACC; Transforming acidic coiled-coil-containing protein (TACC)

  26. NM_001352800.2 → NP_001339729.1  transforming acidic coiled-coil-containing protein 1 isoform 19

    Status: REVIEWED

    Source sequence(s)
    AC067817
    UniProtKB/TrEMBL
    R4GMT7

  27. NM_001352801.2 → NP_001339730.1  transforming acidic coiled-coil-containing protein 1 isoform 20

    Status: REVIEWED

    Source sequence(s)
    AC067817
    Conserved Domains (1) summary
    pfam05010
    Location:172 → 371
    TACC; Transforming acidic coiled-coil-containing protein (TACC)

  28. NM_001352802.1 → NP_001339731.1  transforming acidic coiled-coil-containing protein 1 isoform 21

    Status: REVIEWED

    Source sequence(s)
    AC067817
    UniProtKB/TrEMBL
    B7Z3G3
    Related
    ENST00000522955.5

  29. NM_001352803.2 → NP_001339732.1  transforming acidic coiled-coil-containing protein 1 isoform 22

    Status: REVIEWED

    Source sequence(s)
    AC067817
    Conserved Domains (1) summary
    pfam05010
    Location:160 → 359
    TACC; Transforming acidic coiled-coil-containing protein (TACC)

  30. NM_001352804.2 → NP_001339733.1  transforming acidic coiled-coil-containing protein 1 isoform 23

    Status: REVIEWED

    Source sequence(s)
    AC016813, AC067817
    Conserved Domains (1) summary
    pfam05010
    Location:132 → 331
    TACC; Transforming acidic coiled-coil-containing protein (TACC)

  31. NM_006283.3 → NP_006274.2  transforming acidic coiled-coil-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_006274.2

    Status: REVIEWED

    Source sequence(s)
    AF049910, AY072876, AY139007, DB084271
    Consensus CDS
    CCDS6109.1
    UniProtKB/Swiss-Prot
    B2RBD9, B4E302, D3DSX6, O75410, Q6Y687, Q86YG7, Q8IUJ2, Q8IUJ3, Q8IUJ4, Q8IZG2, Q8NEY7, Q9UPP9
    Related
    ENSP00000321703.4, ENST00000317827.9
    Conserved Domains (3) summary
    pfam05010
    Location:599 → 798
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam09403
    Location:704 → 797
    FadA; Adhesion protein FadA
    cl21478
    Location:610 → 691
    ATP-synt_B; ATP synthase B/B' CF(0)

RNA

  1. NR_148047.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016813

  2. NR_148048.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016813

  3. NR_148049.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016813, AC067817

  4. NR_148050.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016813, AC067817

  5. NR_148051.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016813, AC067817

  6. NR_148052.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016813

  7. NR_148053.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016813

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    38728582..38853028
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047422141.1 → XP_047278097.1  transforming acidic coiled-coil-containing protein 1 isoform X3

  2. XM_047422142.1 → XP_047278098.1  transforming acidic coiled-coil-containing protein 1 isoform X4

  3. XM_047422145.1 → XP_047278101.1  transforming acidic coiled-coil-containing protein 1 isoform X8

  4. XM_005273629.2 → XP_005273686.1  transforming acidic coiled-coil-containing protein 1 isoform X7

    Conserved Domains (3) summary
    pfam05010
    Location:575 → 774
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam09403
    Location:680 → 773
    FadA; Adhesion protein FadA
    cl21478
    Location:586 → 667
    ATP-synt_B; ATP synthase B/B' CF(0)

  5. XM_011544632.3 → XP_011542934.1  transforming acidic coiled-coil-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011542934.1

    UniProtKB/Swiss-Prot
    O75410
    Conserved Domains (1) summary
    pfam05010
    Location:611 → 810
    TACC; Transforming acidic coiled-coil-containing protein (TACC)

  6. XM_047422147.1 → XP_047278103.1  transforming acidic coiled-coil-containing protein 1 isoform X10

  7. XM_047422140.1 → XP_047278096.1  transforming acidic coiled-coil-containing protein 1 isoform X1

  8. XM_047422144.1 → XP_047278100.1  transforming acidic coiled-coil-containing protein 1 isoform X5

  9. XM_005273625.5 → XP_005273682.1  transforming acidic coiled-coil-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005273682.1

    UniProtKB/Swiss-Prot
    O75410
    Conserved Domains (1) summary
    pfam05010
    Location:611 → 810
    TACC; Transforming acidic coiled-coil-containing protein (TACC)

  10. XM_047422149.1 → XP_047278105.1  transforming acidic coiled-coil-containing protein 1 isoform X10

    Related
    ENSP00000428253.1, ENST00000521866.5

  11. XM_047422138.1 → XP_047278094.1  transforming acidic coiled-coil-containing protein 1 isoform X1

  12. XM_047422139.1 → XP_047278095.1  transforming acidic coiled-coil-containing protein 1 isoform X2

    UniProtKB/Swiss-Prot
    B2RBD9, B4E302, D3DSX6, O75410, Q6Y687, Q86YG7, Q8IUJ2, Q8IUJ3, Q8IUJ4, Q8IZG2, Q8NEY7, Q9UPP9

  13. XM_047422143.1 → XP_047278099.1  transforming acidic coiled-coil-containing protein 1 isoform X5

  14. XM_047422148.1 → XP_047278104.1  transforming acidic coiled-coil-containing protein 1 isoform X10

  15. XM_005273628.2 → XP_005273685.1  transforming acidic coiled-coil-containing protein 1 isoform X6

    Conserved Domains (3) summary
    pfam05010
    Location:583 → 782
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam09403
    Location:688 → 781
    FadA; Adhesion protein FadA
    cl21478
    Location:594 → 675
    ATP-synt_B; ATP synthase B/B' CF(0)

  16. XM_047422146.1 → XP_047278102.1  transforming acidic coiled-coil-containing protein 1 isoform X9

  17. XM_047422150.1 → XP_047278106.1  transforming acidic coiled-coil-containing protein 1 isoform X10

  18. XM_011544636.3 → XP_011542938.1  transforming acidic coiled-coil-containing protein 1 isoform X12

    UniProtKB/Swiss-Prot
    O75410
    Conserved Domains (2) summary
    pfam05010
    Location:161 → 360
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam09403
    Location:271 → 359
    FadA; Adhesion protein FadA

  19. XM_047422151.1 → XP_047278107.1  transforming acidic coiled-coil-containing protein 1 isoform X11

    UniProtKB/TrEMBL
    E7EVI4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    39005551..39130036
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054361089.1 → XP_054217064.1  transforming acidic coiled-coil-containing protein 1 isoform X3

  2. XM_054361090.1 → XP_054217065.1  transforming acidic coiled-coil-containing protein 1 isoform X4

  3. XM_054361095.1 → XP_054217070.1  transforming acidic coiled-coil-containing protein 1 isoform X8

  4. XM_054361093.1 → XP_054217068.1  transforming acidic coiled-coil-containing protein 1 isoform X7

  5. XM_054361087.1 → XP_054217062.1  transforming acidic coiled-coil-containing protein 1 isoform X1

  6. XM_054361097.1 → XP_054217072.1  transforming acidic coiled-coil-containing protein 1 isoform X10

  7. XM_054361088.1 → XP_054217063.1  transforming acidic coiled-coil-containing protein 1 isoform X1

  8. XM_054361094.1 → XP_054217069.1  transforming acidic coiled-coil-containing protein 1 isoform X5

  9. XM_054361086.1 → XP_054217061.1  transforming acidic coiled-coil-containing protein 1 isoform X1

  10. XM_054361099.1 → XP_054217074.1  transforming acidic coiled-coil-containing protein 1 isoform X10

  11. XM_054361084.1 → XP_054217059.1  transforming acidic coiled-coil-containing protein 1 isoform X1

  12. XM_054361085.1 → XP_054217060.1  transforming acidic coiled-coil-containing protein 1 isoform X2

    UniProtKB/Swiss-Prot
    B2RBD9, B4E302, D3DSX6, O75410, Q6Y687, Q86YG7, Q8IUJ2, Q8IUJ3, Q8IUJ4, Q8IZG2, Q8NEY7, Q9UPP9

  13. XM_054361091.1 → XP_054217066.1  transforming acidic coiled-coil-containing protein 1 isoform X5

  14. XM_054361098.1 → XP_054217073.1  transforming acidic coiled-coil-containing protein 1 isoform X10

  15. XM_054361092.1 → XP_054217067.1  transforming acidic coiled-coil-containing protein 1 isoform X6

  16. XM_054361096.1 → XP_054217071.1  transforming acidic coiled-coil-containing protein 1 isoform X9

  17. XM_054361100.1 → XP_054217075.1  transforming acidic coiled-coil-containing protein 1 isoform X10

  18. XM_054361102.1 → XP_054217077.1  transforming acidic coiled-coil-containing protein 1 isoform X12

  19. XM_054361101.1 → XP_054217076.1  transforming acidic coiled-coil-containing protein 1 isoform X11

    UniProtKB/TrEMBL
    E7EVI4
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O75410.2 GenPept UniProtKB/Swiss-Prot:O75410

Gene LinkOut

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