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En1 engrailed homeobox 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 685360, updated on 17-Aug-2024

Summary

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Official Symbol
En1provided by RGD
Official Full Name
engrailed homeobox 1provided by RGD
Primary source
RGD:1595088
See related
EnsemblRapid:ENSRNOG00000056580 AllianceGenome:RGD:1595088
Gene type
protein coding
RefSeq status
INFERRED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in response to cocaine. Located in membrane and nucleus. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human EN1 (engrailed homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 17.4), Testes (RPKM 10.8) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See En1 in Genome Data Viewer
Location:
13q11
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (34303684..34309269)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (31750892..31756477)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (36532758..36537888)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene complement C1q like 2 Neighboring gene macrophage receptor with collagenous structure Neighboring gene uncharacterized LOC134481552 Neighboring gene tumor protein, translationally-controlled 1, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. [The functions of GLI3 and EN1 genes in idiopathic congenital talipes equinovarus]. Cao DH, et al. Yi Chuan, 2009 Dec. PMID 20042388
  2. Chronic cocaine administration modulates the expression of transcription factors involved in midbrain dopaminergic neuron function. Leo D, et al. Exp Neurol, 2007 Feb. PMID 17070804
  3. A method of utrophin up-regulation through RNAi-mediated knockdown of the transcription factor EN1. Wang Q, et al. J Int Med Res, 2011. PMID 21672318
  4. Association of transcription factor polymorphisms PITX3 and EN1 with Parkinson's disease. Haubenberger D, et al. Neurobiol Aging, 2011 Feb. PMID 19345444
  5. Progressive loss of dopaminergic neurons in the ventral midbrain of adult mice heterozygote for Engrailed1. Sonnier L, et al. J Neurosci, 2007 Jan 31. PMID 17267560, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The low expression level of EN1 contribute to the up-regulation of GLI3 in idiopathic congenital talipes equinovarus.
    Title: [The functions of GLI3 and EN1 genes in idiopathic congenital talipes equinovarus].
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in adult locomotory behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in cerebellum development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within dopaminergic neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within dorsal/ventral pattern formation ISO
Inferred from Sequence Orthology
more info
  
involved_in drinking behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in embryonic brain development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within embryonic forelimb morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within embryonic limb morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in embryonic limb morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within hindbrain development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within limb development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within midbrain development ISO
Inferred from Sequence Orthology
more info
  
involved_in midbrain development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within midbrain-hindbrain boundary development ISO
Inferred from Sequence Orthology
more info
  
involved_in motor learning ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within multicellular organism growth ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuron development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within pigmentation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within proximal/distal pattern formation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in response to cocaine IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in social behavior ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
homeobox protein engrailed-1
Names
engrailed 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398705.1 → NP_001385634.1  homeobox protein engrailed-1

    Status: INFERRED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A0A0G2JT82
    Related
    ENSRNOP00000068605.3, ENSRNOT00000083007.3
    Conserved Domains (2) summary
    pfam00046
    Location:323 → 377
    Homeobox; Homeobox domain
    pfam10525
    Location:378 → 408
    Engrail_1_C_sig; Engrailed homeobox C-terminal signature domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    34303684..34309269
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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