U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Acot4 acyl-CoA thioesterase 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 681337, updated on 17-Aug-2024

Summary

Go to the top of the page Help
Official Symbol
Acot4provided by RGD
Official Full Name
acyl-CoA thioesterase 4provided by RGD
Primary source
RGD:1596753
See related
EnsemblRapid:ENSRNOG00000046864 AllianceGenome:RGD:1596753
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable acyl-CoA hydrolase activity and succinyl-CoA hydrolase activity. Predicted to be involved in carboxylic acid metabolic process; saturated monocarboxylic acid metabolic process; and succinyl-CoA metabolic process. Predicted to be active in peroxisome. Orthologous to human ACOT4 (acyl-CoA thioesterase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 97.1), Liver (RPKM 90.9) and 2 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Acot4 in Genome Data Viewer
Location:
6q31
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (109399032..109405138)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (103668699..103674037)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (107517668..107522952)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene acyl-CoA thioesterase 1 Neighboring gene ribosomal protein L23A like 8 Neighboring gene acyl-CoA thioesterase 3 Neighboring gene acyl-CoA thioesterase 5

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The identification of a succinyl-CoA thioesterase suggests a novel pathway for succinate production in peroxisomes. Westin MA, et al. J Biol Chem, 2005 Nov 18. PMID 16141203
  2. Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease. Kikuchi M, et al. J Biol Chem, 2004 Jan 2. PMID 14561759
  3. A proteome-wide perspective on peroxisome targeting signal 1(PTS1)-Pex5p affinities. Ghosh D, et al. J Am Chem Soc, 2010 Mar 24. PMID 20178365
  4. Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. Hunt MC, et al. FASEB J, 2006 Sep. PMID 16940157
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables fatty acyl-CoA hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fatty acyl-CoA hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
enables succinyl-CoA hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in acyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in acyl-CoA metabolic process ISO
Inferred from Sequence Orthology
more info
  
NOT involved_in butyrate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in dicarboxylic acid catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in dicarboxylic acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in long-chain fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in saturated monocarboxylic acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in short-chain fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in succinyl-CoA metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in unsaturated monocarboxylic acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in very long-chain fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
acyl-coenzyme A thioesterase 4
NP_001102910.1
XP_038968847.2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109440.2 → NP_001102910.1  acyl-coenzyme A thioesterase 4

    See identical proteins and their annotated locations for NP_001102910.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A6JDS7, D3ZIQ1
    Related
    ENSRNOP00000013754.3, ENSRNOT00000013753.6
    Conserved Domains (2) summary
    pfam04775
    Location:17 → 137
    Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region
    pfam08840
    Location:203 → 412
    BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    109399032..109405138
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039112919.2 → XP_038968847.2  acyl-coenzyme A thioesterase 4 isoform X1

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous