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Cby2 chibby family member 2 [ Mus musculus (house mouse) ]

Gene ID: 67926, updated on 17-Aug-2024

Summary

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Official Symbol
Cby2provided by MGI
Official Full Name
chibby family member 2provided by MGI
Primary source
MGI:MGI:1915176
See related
Ensembl:ENSMUSG00000034913 AllianceGenome:MGI:1915176
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nurit; Spert; 1700086N05Rik
Summary
Predicted to enable identical protein binding activity. Located in cytoplasmic vesicle. Is expressed in seminiferous tubule; spermatid; and testis. Orthologous to human CBY2 (chibby family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 310.1) See more
Orthologs
human all
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Genomic context

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Location:
14 D3; 14 40.23 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (75820274..75830616, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (75582834..75593177, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene siah E3 ubiquitin protein ligase family member 3 Neighboring gene predicted gene, 35966 Neighboring gene predicted gene, 36060 Neighboring gene predicted gene, 36219 Neighboring gene glutamate rich 6B Neighboring gene predicted gene, 23622

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Nurit, a novel leucine-zipper protein, expressed uniquely in the spermatid flower-like structure. Feige E, et al. Mech Dev, 2002 Sep. PMID 12204287
  2. CRISPR/Cas9-mediated genome editing reveals 12 testis-enriched genes dispensable for male fertility in mice. Oyama Y, et al. Asian J Androl, 2022 May-Jun. PMID 34290169, Free PMC Article
  3. A targeted mutation of Nkd1 impairs mouse spermatogenesis. Li Q, et al. J Biol Chem, 2005 Jan 28. PMID 15546883
  4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Clone Names

  • MGC129307

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein chibby homolog 2
Names
novel leucine zipper testicular protein
protein nurit
spermatid associated
spermatid-associated protein
testis-specific leucine zipper protein nurit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164139.1 → NP_001157611.1  protein chibby homolog 2 isoform 1

    See identical proteins and their annotated locations for NP_001157611.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC125205
    Consensus CDS
    CCDS49543.1
    UniProtKB/Swiss-Prot
    Q32MG2, Q8CIV5, Q9D9E6, Q9D9Z0
    Related
    ENSMUSP00000127439.2, ENSMUST00000164082.9
    Conserved Domains (2) summary
    cd07429
    Location:76 → 191
    Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins
    cl12007
    Location:302 → 424
    Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins

  2. NM_001164140.1 → NP_001157612.1  protein chibby homolog 2 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AC125205
    Consensus CDS
    CCDS49542.1
    UniProtKB/TrEMBL
    E9Q4B1
    Related
    ENSMUSP00000129616.2, ENSMUST00000169658.9
    Conserved Domains (2) summary
    cd07429
    Location:49 → 164
    Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins
    cl12007
    Location:275 → 397
    Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins

  3. NM_001164141.1 → NP_001157613.1  protein chibby homolog 2 isoform 3

    See identical proteins and their annotated locations for NP_001157613.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC125205
    Consensus CDS
    CCDS49541.1
    UniProtKB/Swiss-Prot
    Q32MG2
    Related
    ENSMUSP00000131347.2, ENSMUST00000165569.3
    Conserved Domains (2) summary
    cd07429
    Location:2 → 113
    Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins
    cl12007
    Location:290 → 346
    Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins

  4. NM_026457.2 → NP_080733.2  protein chibby homolog 2 isoform 2

    See identical proteins and their annotated locations for NP_080733.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK005703, AK006329, AK007022
    Consensus CDS
    CCDS27279.1
    UniProtKB/Swiss-Prot
    Q32MG2
    Related
    ENSMUSP00000046259.4, ENSMUST00000035243.5
    Conserved Domains (2) summary
    cd07429
    Location:40 → 155
    Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins
    cl12007
    Location:266 → 388
    Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    75820274..75830616 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247977.2 → XP_030103837.1  protein chibby homolog 2 isoform X1

    Conserved Domains (2) summary
    cd07429
    Location:2 → 113
    Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins
    cl12007
    Location:290 → 346
    Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins

  2. XM_011245167.2 → XP_011243469.1  protein chibby homolog 2 isoform X1

    See identical proteins and their annotated locations for XP_011243469.1

    UniProtKB/Swiss-Prot
    Q32MG2
    Conserved Domains (2) summary
    cd07429
    Location:2 → 113
    Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins
    cl12007
    Location:290 → 346
    Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins

  3. XM_011245168.2 → XP_011243470.1  protein chibby homolog 2 isoform X1

    See identical proteins and their annotated locations for XP_011243470.1

    UniProtKB/Swiss-Prot
    Q32MG2
    Conserved Domains (2) summary
    cd07429
    Location:2 → 113
    Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins
    cl12007
    Location:290 → 346
    Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins

  4. XM_030247978.2 → XP_030103838.1  protein chibby homolog 2 isoform X1

    Conserved Domains (2) summary
    cd07429
    Location:2 → 113
    Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins
    cl12007
    Location:290 → 346
    Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins

  5. XM_030247981.1 → XP_030103841.1  protein chibby homolog 2 isoform X1

    Conserved Domains (2) summary
    cd07429
    Location:2 → 113
    Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins
    cl12007
    Location:290 → 346
    Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins

  6. XM_030247979.1 → XP_030103839.1  protein chibby homolog 2 isoform X1

    Conserved Domains (2) summary
    cd07429
    Location:2 → 113
    Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins
    cl12007
    Location:290 → 346
    Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins

  7. XM_030247980.1 → XP_030103840.1  protein chibby homolog 2 isoform X1

    Conserved Domains (2) summary
    cd07429
    Location:2 → 113
    Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins
    cl12007
    Location:290 → 346
    Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q32MG2.2 GenPept UniProtKB/Swiss-Prot:Q32MG2

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