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f9b coagulation factor IXb [ Danio rerio (zebrafish) ]

Gene ID: 678552, updated on 2-Nov-2024

Summary

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Official Symbol
f9bprovided by ZNC
Official Full Name
coagulation factor IXbprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060421-7346
See related
Ensembl:ENSDARG00000029493 AllianceGenome:ZFIN:ZDB-GENE-060421-7346
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:136807
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in blood coagulation. Predicted to act upstream of or within proteolysis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in X-linked thrombophilia due to factor IX defect; X-linked warfarin sensitivity; and hemophilia B. Orthologous to human F9 (coagulation factor IX). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See f9b in Genome Data Viewer
Location:
chromosome: 10
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (26747795..26757486)
105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (26786082..26795773)

Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene teleost multiple tissue opsin 3b Neighboring gene fibroblast growth factor 13b Neighboring gene proto-oncogene DBL Neighboring gene uncharacterized LOC110438858 Neighboring gene arrestin 3a, retinal (X-arrestin)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Identification of zebrafish ortholog for human coagulation factor IX and its age-dependent expression. Iyer N, et al. J Thromb Haemost, 2021 Sep. PMID 33974340
  2. Genetic duplication of tissue factor reveals subfunctionalization in venous and arterial hemostasis. Grzegorski SJ, et al. PLoS Genet, 2022 Nov. PMID 36449521, Free PMC Article
  3. 17β-Estradiol and the glucocorticoid clobetasol propionate affect the blood coagulation cascade in zebrafish. Schmid S, et al. Environ Pollut, 2020 Apr. PMID 31887585
  4. Disruption of liver development and coagulation pathway by ochratoxin A in embryonic zebrafish. Wu TS, et al. Toxicol Appl Pharmacol, 2018 Feb 1. PMID 29274910
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC136807

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in blood coagulation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within blood coagulation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
coagulation factor IXb
NP_001035400.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040310.1 → NP_001035400.1  coagulation factor IXb precursor

    See identical proteins and their annotated locations for NP_001035400.1

    Status: PROVISIONAL

    Source sequence(s)
    BC115275
    UniProtKB/TrEMBL
    A0A8M1N907, Q1RLV2
    Related
    ENSDARP00000091102.3, ENSDART00000100329.4
    Conserved Domains (5) summary
    smart00020
    Location:255 → 487
    Tryp_SPc; Trypsin-like serine protease
    smart00069
    Location:23 → 86
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues
    cd00054
    Location:88 → 124
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00190
    Location:256 → 490
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam14670
    Location:131 → 167
    FXa_inhibition; Coagulation Factor Xa inhibitory site

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007121.7 Reference GRCz11 Primary Assembly

    Range
    26747795..26757486
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394787.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    2200..11891
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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