U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ilf2 interleukin enhancer binding factor 2 [ Mus musculus (house mouse) ]

Gene ID: 67781, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Ilf2provided by MGI
Official Full Name
interleukin enhancer binding factor 2provided by MGI
Primary source
MGI:MGI:1915031
See related
Ensembl:ENSMUSG00000001016 AllianceGenome:MGI:1915031
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tex261; Tex267; TEG-267; 6230405A16Rik
Summary
Predicted to enable DNA binding activity and double-stranded RNA binding activity. Predicted to be involved in positive regulation of DNA-templated transcription. Located in nucleolus. Is expressed in several structures, including brain; early conceptus; ganglia; gonad; and incisor. Orthologous to human ILF2 (interleukin enhancer binding factor 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E11.5 (RPKM 75.1), CNS E14 (RPKM 54.2) and 22 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Ilf2 in Genome Data Viewer
Location:
3 F1; 3 39.23 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (90383421..90395686)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (90476201..90488379)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene natriuretic peptide receptor 1 Neighboring gene STARR-positive B cell enhancer ABC_E6072 Neighboring gene STARR-positive B cell enhancer ABC_E56 Neighboring gene nuclear encoded tRNA methionine 11 (anticodon CAT) Neighboring gene STARR-positive B cell enhancer ABC_E2084 Neighboring gene SNAP-associated protein Neighboring gene chromatin target of PRMT1 Neighboring gene STARR-positive B cell enhancer ABC_E2085 Neighboring gene STARR-seq mESC enhancer starr_08290 Neighboring gene S100 calcium binding protein A1 Neighboring gene S100 calcium binding protein A13

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. NF45 dimerizes with NF90, Zfr and SPNR via a conserved domain that has a nucleotidyltransferase fold. Wolkowicz UM, et al. Nucleic Acids Res, 2012 Oct. PMID 22833610, Free PMC Article
  2. NF45 and NF90/NF110 coordinately regulate ESC pluripotency and differentiation. Ye J, et al. RNA, 2017 Aug. PMID 28487382, Free PMC Article
  3. NF45 and NF90 in murine seminiferous epithelium: potential role in SP-10 gene transcription. Ranpura SA, et al. J Androl, 2008 Mar-Apr. PMID 17942973
  4. NF90-NF45 is essential for β cell compensation under obesity-inducing metabolic stress through suppression of p53 signaling pathway. Lai S, et al. Sci Rep, 2022 May 25. PMID 35614067, Free PMC Article
  5. Overexpression of NF90-NF45 Represses Myogenic MicroRNA Biogenesis, Resulting in Development of Skeletal Muscle Atrophy and Centronuclear Muscle Fibers. Todaka H, et al. Mol Cell Biol, 2015 Jul. PMID 25918244, Free PMC Article

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data support a model in which NF45, NF90, and NF110 operate in feedback loops that enable them, through both overlapping and independent targets, to help balance the push and pull of pluripotency and differentiation cues.
    Title: NF45 and NF90/NF110 coordinately regulate ESC pluripotency and differentiation.
  2. NF90-NF45 complex induces centronuclear myopathy through increased dynamin 2 expression by an NF90-NF45-induced reduction of miR-133a expression in vivo.
    Title: Overexpression of NF90-NF45 Represses Myogenic MicroRNA Biogenesis, Resulting in Development of Skeletal Muscle Atrophy and Centronuclear Muscle Fibers.
  3. we propose that NF45 and NF90 have the potential to activate SP-10 gene transcription, and that a chromatin modification event must occur first in order to provide access to these transcription factors.
    Title: NF45 and NF90 in murine seminiferous epithelium: potential role in SP-10 gene transcription.
  4. Ilf2 is regulated during meiosis and associated to transcriptionally active chromatin
    Title: Ilf2 is regulated during meiosis and associated to transcriptionally active chromatin.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
interleukin enhancer-binding factor 2
Names
nuclear factor of activated T-cells 45 kDa
testis expressed gene 267

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026374.3 → NP_080650.1  interleukin enhancer-binding factor 2

    See identical proteins and their annotated locations for NP_080650.1

    Status: PROVISIONAL

    Source sequence(s)
    AC160552
    Consensus CDS
    CCDS17530.1
    UniProtKB/Swiss-Prot
    Q3U083, Q5RKG0, Q8CCY9, Q99KS3, Q9CXY6
    UniProtKB/TrEMBL
    Q3UXI9
    Related
    ENSMUSP00000001042.9, ENSMUST00000001042.10
    Conserved Domains (1) summary
    smart00572
    Location:98 → 338
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    90383421..90395686
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163253.1 → XP_036019146.1  interleukin enhancer-binding factor 2 isoform X1

    Conserved Domains (1) summary
    cl02675
    Location:1 → 182
    DZF; DZF domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CXY6.1 GenPept UniProtKB/Swiss-Prot:Q9CXY6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous