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SRPK2 SRSF protein kinase 2 [ Homo sapiens (human) ]

Gene ID: 6733, updated on 14-Nov-2024

Summary

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Official Symbol
SRPK2provided by HGNC
Official Full Name
SRSF protein kinase 2provided by HGNC
Primary source
HGNC:HGNC:11306
See related
Ensembl:ENSG00000135250 MIM:602980; AllianceGenome:HGNC:11306
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SFRSK2
Summary
Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in several processes, including R-loop processing; peptidyl-serine phosphorylation; and regulation of viral genome replication. Located in chromatin; cytosol; and nuclear lumen. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis (RPKM 31.3), brain (RPKM 21.9) and 24 other tissues See more
Orthologs
mouse all
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Genomic context

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See SRPK2 in Genome Data Viewer
Location:
7q22.3
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (105114740..105399357, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (106428390..106713586, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (104756821..105029838, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26452 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26453 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:104627453-104627954 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:104627955-104628454 Neighboring gene long intergenic non-protein coding RNA 1004 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:104652040-104652580 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26454 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18513 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26457 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26456 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18512 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:104653661-104654200 Neighboring gene KMT2E antisense RNA 1 Neighboring gene lysine methyltransferase 2E (inactive) Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18514 Neighboring gene uncharacterized LOC124901717 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18515 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:104782308-104782484 Neighboring gene uncharacterized LOC124901718 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:104868816-104869316 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:104885101-104885641 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26458 Neighboring gene ribosomal protein L36 pseudogene 12 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26459 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26460 Neighboring gene RWD domain containing 4 pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:104981783-104982284 Neighboring gene RNA, U6 small nuclear 1322, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26461 Neighboring gene small integral membrane protein 12-like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:105017433-105018419 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18518 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18521 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18520 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18519 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18517 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18516 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:105044328-105044513 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26462 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:105107997-105108545 Neighboring gene pseudouridine synthase 7 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:105160613-105161230 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:105161545-105162199 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:105163483-105163983 Neighboring gene ring finger protein 181 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. SRPK2 Mediates HBV Core Protein Phosphorylation and Capsid Assembly via Docking Interaction. Yip RPH, et al. PLoS Pathog, 2024 Feb. PMID 38324561, Free PMC Article
  2. Serine/arginine protein-specific kinase 2 promotes the development and progression of pancreatic cancer by downregulating Numb and p53. Wang G, et al. FEBS J, 2019 May. PMID 30724469
  3. Enhanced expression of SRPK2 contributes to aggressive progression and metastasis in prostate cancer. Zhuo YJ, et al. Biomed Pharmacother, 2018 Jun. PMID 29587239
  4. The pre-mRNA alternative splicing regulated by SRPK2: A new player in alcohol-associated liver disease? Yang Z, et al. Hepatology, 2023 Nov 1. PMID 37183907, Free PMC Article
  5. SRPK2 promotes the growth and migration of the colon cancer cells. Wang J, et al. Gene, 2016 Jul 15. PMID 27041240

See all (132) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SRPK2 Mediates HBV Core Protein Phosphorylation and Capsid Assembly via Docking Interaction.
    Title: SRPK2 Mediates HBV Core Protein Phosphorylation and Capsid Assembly via Docking Interaction.
  2. The pre-mRNA alternative splicing regulated by SRPK2: A new player in alcohol-associated liver disease?
    Title: The pre-mRNA alternative splicing regulated by SRPK2: A new player in alcohol-associated liver disease?
  3. Stress Granules Determine the Development of Obesity-Associated Pancreatic Cancer.
    Title: Stress Granules Determine the Development of Obesity-Associated Pancreatic Cancer.
  4. Inhibition of Long Noncoding RNA Linc-Pint by Hepatitis C Virus in Infected Hepatocytes Enhances Lipogenesis.
    Title: Inhibition of Long Noncoding RNA Linc-Pint by Hepatitis C Virus in Infected Hepatocytes Enhances Lipogenesis.
  5. SRPK1/2 and PP1alpha exert opposite functions by modulating SRSF1-guided MKNK2 alternative splicing in colon adenocarcinoma.
    Title: SRPK1/2 and PP1α exert opposite functions by modulating SRSF1-guided MKNK2 alternative splicing in colon adenocarcinoma.
  6. Cooperation of SRPK2, Numb and p53 in the malignant biology and chemosensitivity of colorectal cancer.
    Title: Cooperation of SRPK2, Numb and p53 in the malignant biology and chemosensitivity of colorectal cancer.
  7. Serine-Arginine Protein Kinase SRPK2 Modulates the Assembly of the Active Zone Scaffolding Protein CAST1/ERC2.
    Title: Serine-Arginine Protein Kinase SRPK2 Modulates the Assembly of the Active Zone Scaffolding Protein CAST1/ERC2.
  8. SRPK2 expression was upregulated in pancreatic cancer tissues, positively correlated with stage, and associated with decreased overall survival in pancreatic cancer patients. In pancreatic cancer cells, SRPK2 overexpression promoted cell invasion and migration, and decreased chemosensitivity to gemcitabine or oxaliplatin. SRPK2 silencing decreased cell invasion and migration and increased chemosensitivity.
    Title: Serine/arginine protein-specific kinase 2 promotes the development and progression of pancreatic cancer by downregulating Numb and p53.
  9. The conserved SRPK-specific substrate-docking groove in SRPK2 impacts the binding and phosphorylation of both SR proteins, and the localization of SRSF3.
    Title: Distinct mechanisms govern the phosphorylation of different SR protein splicing factors.
  10. SRPK2 may play an important role in the progression and metastasis of prostate cancer.
    Title: Enhanced expression of SRPK2 contributes to aggressive progression and metastasis in prostate cancer.
Submit: New GeneRIF Correction See all GeneRIFs (26)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.
EBI GWAS Catalog
Biological insights from 108 schizophrenia-associated genetic loci.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ36101

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 14-3-3 protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables 3-phosphoinositide-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding HDA PubMed 
enables Rho-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables eukaryotic translation initiation factor 2alpha kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS121 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AT120 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AXS139 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS14 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS36 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S10 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S28 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S57 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T11 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T3 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T45 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H4S1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables ribosomal protein S6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in R-loop processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in RNA splicing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in innate immune response IC
Inferred by Curator
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of viral genome replication IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nuclear speck organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in peptidyl-serine phosphorylation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of neuron apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of viral genome replication IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of mRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mRNA splicing, via spliceosome TAS
Traceable Author Statement
more info
 PubMed 
involved_in spliceosomal complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spliceosomal complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in presynapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
SRSF protein kinase 2
Names
SFRS protein kinase 2
SR protein kinase 2
SR-protein-specific kinase 2
serine kinase SRPK2
serine/arginine-rich protein-specific kinase 2
serine/arginine-rich splicing factor kinase 2
serine/threonine-protein kinase SRPK2
NP_001265202.1
NP_001337667.1
NP_001337668.1
NP_001337669.1
NP_001337670.1
NP_001337671.1
NP_001337672.1
NP_001337673.1
NP_001337674.1
NP_001337675.1
NP_872633.1
NP_872634.1
XP_006716161.1
XP_011514838.1
XP_011514840.1
XP_016868050.2
XP_024302661.1
XP_024302662.1
XP_024302663.1
XP_047276728.1
XP_047276729.1
XP_047276730.1
XP_047276731.1
XP_047276732.1
XP_054214855.1
XP_054214856.1
XP_054214857.1
XP_054214858.1
XP_054214859.1
XP_054214860.1
XP_054214861.1
XP_054214862.1
XP_054214863.1
XP_054214864.1
XP_054214865.1
XP_054214866.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278273.2 → NP_001265202.1  SRSF protein kinase 2 isoform b precursor

    See identical proteins and their annotated locations for NP_001265202.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
    Source sequence(s)
    AC004884, AC005070, BC035214, BC068547, BU632662
    Consensus CDS
    CCDS5735.1
    UniProtKB/Swiss-Prot
    A8MVX2, O75220, O75221, P78362, Q6NUL0, Q6V1X2, Q8IYQ3
    UniProtKB/TrEMBL
    H7C5L6
    Related
    ENSP00000419791.1, ENST00000489828.5
    Conserved Domains (2) summary
    cl21453
    Location:68 → 256
    PKc_like; Protein Kinases, catalytic domain
    cl27511
    Location:341 → 383
    Na_Ca_ex; Sodium/calcium exchanger protein

  2. NM_001350738.2 → NP_001337667.1  SRSF protein kinase 2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variants 2 and 3, encodes isoform b.
    Source sequence(s)
    AC004884, AC005070, AC073138
    Consensus CDS
    CCDS5735.1
    UniProtKB/Swiss-Prot
    A8MVX2, O75220, O75221, P78362, Q6NUL0, Q6V1X2, Q8IYQ3
    UniProtKB/TrEMBL
    H7C5L6
    Conserved Domains (2) summary
    cl21453
    Location:68 → 256
    PKc_like; Protein Kinases, catalytic domain
    cl27511
    Location:341 → 383
    Na_Ca_ex; Sodium/calcium exchanger protein

  3. NM_001350739.2 → NP_001337668.1  SRSF protein kinase 2 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC004884, AC005070
    UniProtKB/TrEMBL
    H7C5L6
    Conserved Domains (3) summary
    cd14217
    Location:68 → 256
    STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
    cl21453
    Location:504 → 686
    PKc_like; Protein Kinases, catalytic domain
    cl27511
    Location:341 → 383
    Na_Ca_ex; Sodium/calcium exchanger protein

  4. NM_001350740.2 → NP_001337669.1  SRSF protein kinase 2 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) encodes the longest isoform (d).
    Source sequence(s)
    AC005070, AC073138
    Conserved Domains (3) summary
    cd14217
    Location:116 → 304
    STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
    cl21453
    Location:552 → 734
    PKc_like; Protein Kinases, catalytic domain
    cl27511
    Location:389 → 431
    Na_Ca_ex; Sodium/calcium exchanger protein

  5. NM_001350741.2 → NP_001337670.1  SRSF protein kinase 2 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC005070, AC073138
    UniProtKB/TrEMBL
    H7C5L6
    Conserved Domains (2) summary
    cl21453
    Location:79 → 267
    PKc_like; Protein Kinases, catalytic domain
    cl27511
    Location:352 → 394
    Na_Ca_ex; Sodium/calcium exchanger protein

  6. NM_001350742.2 → NP_001337671.1  SRSF protein kinase 2 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC004884, AC005070, AC073138
    Consensus CDS
    CCDS94172.1
    UniProtKB/TrEMBL
    A0A994J591, H7C5L6
    Related
    ENSP00000516319.1, ENST00000482862.2
    Conserved Domains (3) summary
    cd14217
    Location:105 → 293
    STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
    cl21453
    Location:541 → 723
    PKc_like; Protein Kinases, catalytic domain
    cl27511
    Location:378 → 420
    Na_Ca_ex; Sodium/calcium exchanger protein

  7. NM_001350743.2 → NP_001337672.1  SRSF protein kinase 2 isoform g

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9), as well as variant 10, encodes isoform g.
    Source sequence(s)
    AC004884, AC005070, AC073138
    Consensus CDS
    CCDS94171.1
    UniProtKB/TrEMBL
    C9J2M4, H7C5L6
    Related
    ENSP00000417357.2, ENST00000460391.6
    Conserved Domains (3) summary
    cd14217
    Location:68 → 256
    STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
    cl21453
    Location:504 → 717
    PKc_like; Protein Kinases, catalytic domain
    cl27511
    Location:341 → 383
    Na_Ca_ex; Sodium/calcium exchanger protein

  8. NM_001350744.2 → NP_001337673.1  SRSF protein kinase 2 isoform g

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10), as well as variant 9, encodes isoform g.
    Source sequence(s)
    AC004884, AC005070
    Consensus CDS
    CCDS94171.1
    UniProtKB/TrEMBL
    C9J2M4, H7C5L6
    Conserved Domains (3) summary
    cd14217
    Location:68 → 256
    STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
    cl21453
    Location:504 → 717
    PKc_like; Protein Kinases, catalytic domain
    cl27511
    Location:341 → 383
    Na_Ca_ex; Sodium/calcium exchanger protein

  9. NM_001350745.2 → NP_001337674.1  SRSF protein kinase 2 isoform h

    Status: VALIDATED

    Source sequence(s)
    AC004884, AC005070
    UniProtKB/TrEMBL
    H7C5L6
    Conserved Domains (1) summary
    cl21453
    Location:70 → 640
    PKc_like; Protein Kinases, catalytic domain

  10. NM_001350746.2 → NP_001337675.1  SRSF protein kinase 2 isoform i

    Status: VALIDATED

    Source sequence(s)
    AC004884, AC005070, AC073138
    Conserved Domains (3) summary
    cd14217
    Location:105 → 293
    STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
    cl21453
    Location:545 → 610
    PKc_like; Protein Kinases, catalytic domain
    cl27511
    Location:378 → 420
    Na_Ca_ex; Sodium/calcium exchanger protein

  11. NM_182691.3 → NP_872633.1  SRSF protein kinase 2 isoform b precursor

    See identical proteins and their annotated locations for NP_872633.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate first exon compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
    Source sequence(s)
    BC035214, BU632662, CR746049, DA592321
    Consensus CDS
    CCDS5735.1
    UniProtKB/Swiss-Prot
    A8MVX2, O75220, O75221, P78362, Q6NUL0, Q6V1X2, Q8IYQ3
    UniProtKB/TrEMBL
    H7C5L6
    Related
    ENSP00000349863.3, ENST00000357311.7
    Conserved Domains (2) summary
    cl21453
    Location:68 → 256
    PKc_like; Protein Kinases, catalytic domain
    cl27511
    Location:341 → 383
    Na_Ca_ex; Sodium/calcium exchanger protein

  12. NM_182692.3 → NP_872634.1  SRSF protein kinase 2 isoform a

    See identical proteins and their annotated locations for NP_872634.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    BC035214, BU632662, CR746049, HY031357
    Consensus CDS
    CCDS34724.1
    UniProtKB/TrEMBL
    H7C5L6
    Related
    ENSP00000377262.3, ENST00000393651.8
    Conserved Domains (2) summary
    smart00220
    Location:92 → 236
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:79 → 267
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    105114740..105399357 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011516536.4 → XP_011514838.1  SRSF protein kinase 2 isoform X5

    UniProtKB/TrEMBL
    H7C5L6
    Conserved Domains (2) summary
    cd14217
    Location:79 → 267
    STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
    cl21453
    Location:515 → 728
    PKc_like; Protein Kinases, catalytic domain

  2. XM_011516538.3 → XP_011514840.1  SRSF protein kinase 2 isoform X6

    See identical proteins and their annotated locations for XP_011514840.1

    UniProtKB/TrEMBL
    C9J2M4, H7C5L6
    Conserved Domains (3) summary
    cd14217
    Location:68 → 256
    STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
    cl21453
    Location:504 → 717
    PKc_like; Protein Kinases, catalytic domain
    cl27511
    Location:341 → 383
    Na_Ca_ex; Sodium/calcium exchanger protein

  3. XM_024446895.2 → XP_024302663.1  SRSF protein kinase 2 isoform X4

    Conserved Domains (3) summary
    cd14217
    Location:116 → 304
    STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
    cl21453
    Location:552 → 734
    PKc_like; Protein Kinases, catalytic domain
    cl27511
    Location:389 → 431
    Na_Ca_ex; Sodium/calcium exchanger protein

  4. XM_024446894.2 → XP_024302662.1  SRSF protein kinase 2 isoform X3

    Conserved Domains (3) summary
    cd14217
    Location:116 → 304
    STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
    cl21453
    Location:552 → 765
    PKc_like; Protein Kinases, catalytic domain
    cl27511
    Location:389 → 431
    Na_Ca_ex; Sodium/calcium exchanger protein

  5. XM_017012561.3 → XP_016868050.2  SRSF protein kinase 2 isoform X2

    UniProtKB/TrEMBL
    H7C5L6
    Conserved Domains (3) summary
    cd14217
    Location:105 → 293
    STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
    cl21453
    Location:541 → 723
    PKc_like; Protein Kinases, catalytic domain
    cl27511
    Location:378 → 420
    Na_Ca_ex; Sodium/calcium exchanger protein

  6. XM_024446893.2 → XP_024302661.1  SRSF protein kinase 2 isoform X1

    Conserved Domains (3) summary
    cd14217
    Location:105 → 293
    STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
    cl21453
    Location:541 → 754
    PKc_like; Protein Kinases, catalytic domain
    cl27511
    Location:378 → 420
    Na_Ca_ex; Sodium/calcium exchanger protein

  7. XM_047420772.1 → XP_047276728.1  SRSF protein kinase 2 isoform X6

    UniProtKB/TrEMBL
    C9J2M4

  8. XM_047420776.1 → XP_047276732.1  SRSF protein kinase 2 isoform X9

  9. XM_047420773.1 → XP_047276729.1  SRSF protein kinase 2 isoform X7

  10. XM_047420774.1 → XP_047276730.1  SRSF protein kinase 2 isoform X8

    Related
    ENSP00000420208.2, ENST00000477925.6

  11. XM_006716098.4 → XP_006716161.1  SRSF protein kinase 2 isoform X6

    See identical proteins and their annotated locations for XP_006716161.1

    UniProtKB/TrEMBL
    C9J2M4, H7C5L6
    Conserved Domains (3) summary
    cd14217
    Location:68 → 256
    STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
    cl21453
    Location:504 → 717
    PKc_like; Protein Kinases, catalytic domain
    cl27511
    Location:341 → 383
    Na_Ca_ex; Sodium/calcium exchanger protein

  12. XM_047420775.1 → XP_047276731.1  SRSF protein kinase 2 isoform X8

RNA

  1. XR_007060151.1 RNA Sequence

  2. XR_007060150.1 RNA Sequence

  3. XR_007060147.1 RNA Sequence

  4. XR_001744862.3 RNA Sequence

  5. XR_007060153.1 RNA Sequence

  6. XR_007060148.1 RNA Sequence

  7. XR_007060149.1 RNA Sequence

  8. XR_001744863.3 RNA Sequence

  9. XR_001744861.3 RNA Sequence

  10. XR_007060152.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    106428390..106713586 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054358884.1 → XP_054214859.1  SRSF protein kinase 2 isoform X5

  2. XM_054358887.1 → XP_054214862.1  SRSF protein kinase 2 isoform X6

    UniProtKB/TrEMBL
    C9J2M4

  3. XM_054358883.1 → XP_054214858.1  SRSF protein kinase 2 isoform X4

  4. XM_054358882.1 → XP_054214857.1  SRSF protein kinase 2 isoform X3

  5. XM_054358881.1 → XP_054214856.1  SRSF protein kinase 2 isoform X2

  6. XM_054358880.1 → XP_054214855.1  SRSF protein kinase 2 isoform X1

  7. XM_054358886.1 → XP_054214861.1  SRSF protein kinase 2 isoform X6

    UniProtKB/TrEMBL
    C9J2M4

  8. XM_054358891.1 → XP_054214866.1  SRSF protein kinase 2 isoform X9

  9. XM_054358888.1 → XP_054214863.1  SRSF protein kinase 2 isoform X7

  10. XM_054358889.1 → XP_054214864.1  SRSF protein kinase 2 isoform X8

  11. XM_054358885.1 → XP_054214860.1  SRSF protein kinase 2 isoform X6

    UniProtKB/TrEMBL
    C9J2M4

  12. XM_054358890.1 → XP_054214865.1  SRSF protein kinase 2 isoform X8

RNA

  1. XR_008487747.1 RNA Sequence

  2. XR_008487746.1 RNA Sequence

  3. XR_008487742.1 RNA Sequence

  4. XR_008487741.1 RNA Sequence

  5. XR_008487749.1 RNA Sequence

  6. XR_008487744.1 RNA Sequence

  7. XR_008487745.1 RNA Sequence

  8. XR_008487743.1 RNA Sequence

  9. XR_008487740.1 RNA Sequence

  10. XR_008487748.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P78362.3 GenPept UniProtKB/Swiss-Prot:P78362

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