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Psmc6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 [ Mus musculus (house mouse) ]

Gene ID: 67089, updated on 14-Nov-2024

Summary

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Official Symbol
Psmc6provided by MGI
Official Full Name
proteasome (prosome, macropain) 26S subunit, ATPase, 6provided by MGI
Primary source
MGI:MGI:1914339
See related
Ensembl:ENSMUSG00000021832 AllianceGenome:MGI:1914339
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2300001E01Rik
Summary
Predicted to enable identical protein binding activity and proteasome-activating activity. Predicted to be involved in positive regulation of cellular component biogenesis and proteasomal protein catabolic process. Part of proteasome accessory complex. Is expressed in several structures, including brain; genitourinary system; gut; integumental system; and vascular system. Orthologous to human PSMC6 (proteasome 26S subunit, ATPase 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E11.5 (RPKM 59.8), liver E14 (RPKM 50.8) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Psmc6 in Genome Data Viewer
Location:
14 22.89 cM; 14 C1
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (45567285..45587150)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (45329823..45349074)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 137C Neighboring gene STARR-positive B cell enhancer mm9_chr14:45861577-45861878 Neighboring gene endoplasmic reticulum oxidoreductase 1 alpha Neighboring gene STARR-positive B cell enhancer ABC_E3110 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:45949463-45949646 Neighboring gene serine/threonine/tyrosine interaction protein Neighboring gene STARR-seq mESC enhancer starr_36535 Neighboring gene glucosamine-phosphate N-acetyltransferase 1 Neighboring gene predicted gene, 41143

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PSMC6 induces immune cell infiltration and inflammatory response to aggravate primary Sjogren's syndrome.
    Title: PSMC6 induces immune cell infiltration and inflammatory response to aggravate primary Sjögren's syndrome.
  2. PSMC6 promotes osteoblast apoptosis through inhibiting PI3K/AKT signaling pathway activation in ovariectomy-induced osteoporosis mouse model.
    Title: PSMC6 promotes osteoblast apoptosis through inhibiting PI3K/AKT signaling pathway activation in ovariectomy-induced osteoporosis mouse model.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC151129

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables proteasome-activating activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of RNA polymerase II transcription preinitiation complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of inclusion body assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of inclusion body assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of cytosolic proteasome complex IEA
Inferred from Electronic Annotation
more info
  
part_of cytosolic proteasome complex ISO
Inferred from Sequence Orthology
more info
  
located_in inclusion body IEA
Inferred from Electronic Annotation
more info
  
located_in inclusion body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of proteasome accessory complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome complex ISO
Inferred from Sequence Orthology
more info
  
part_of proteasome regulatory particle, base subcomplex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
26S proteasome regulatory subunit 10B
Names
26S protease regulatory subunit 10B
26S protease regulatory subunit S10B
26S proteasome AAA-ATPase subunit RPT4
proteasome 26S subunit ATPase 6
proteasome subunit p42

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001416015.1 → NP_001402944.1  26S proteasome regulatory subunit 10B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154575

  2. NM_025959.4 → NP_080235.2  26S proteasome regulatory subunit 10B isoform 1

    See identical proteins and their annotated locations for NP_080235.2

    Status: VALIDATED

    Source sequence(s)
    AC154575
    Consensus CDS
    CCDS26974.1
    UniProtKB/Swiss-Prot
    P62334, Q3TKK1, Q810A6, Q9CXH9
    UniProtKB/TrEMBL
    Q14AQ1
    Related
    ENSMUSP00000022380.8, ENSMUST00000022380.9
    Conserved Domains (1) summary
    COG1222
    Location:4 → 387
    RPT1; ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    45567285..45587150
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62334.1 GenPept UniProtKB/Swiss-Prot:P62334

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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