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Etfdh electron transferring flavoprotein, dehydrogenase [ Mus musculus (house mouse) ]

Gene ID: 66841, updated on 3-Nov-2024

Summary

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Official Symbol
Etfdhprovided by MGI
Official Full Name
electron transferring flavoprotein, dehydrogenaseprovided by MGI
Primary source
MGI:MGI:106100
See related
Ensembl:ENSMUSG00000027809 AllianceGenome:MGI:106100
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
0610010I20Rik
Summary
Predicted to enable 4 iron, 4 sulfur cluster binding activity; electron-transferring-flavoprotein dehydrogenase activity; and ubiquinone binding activity. Involved in response to oxidative stress. Located in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; integumental system; and nervous system. Human ortholog(s) of this gene implicated in multiple acyl-CoA dehydrogenase deficiency. Orthologous to human ETFDH (electron transfer flavoprotein dehydrogenase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in heart adult (RPKM 102.8), liver adult (RPKM 55.1) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Etfdh in Genome Data Viewer
Location:
3 E3; 3 34.91 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (79511095..79536074, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (79603788..79628767, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene sperm microtubule inner protein 2 Neighboring gene STARR-seq mESC enhancer starr_08000 Neighboring gene folliculin interacting protein 2 Neighboring gene STARR-seq mESC enhancer starr_08002 Neighboring gene RIKEN cDNA 4930589L23 gene Neighboring gene STARR-seq mESC enhancer starr_08006 Neighboring gene RIKEN cDNA 4930579G24 gene Neighboring gene peptidylprolyl isomerase D (cyclophilin D) Neighboring gene relaxin/insulin-like family peptide receptor 1 Neighboring gene STARR-seq mESC enhancer starr_08007 Neighboring gene VISTA enhancer mm1650

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. An ETFDH-driven metabolon supports OXPHOS efficiency in skeletal muscle by regulating coenzyme Q homeostasis. Herrero Martín JC, et al. Nat Metab, 2024 Feb. PMID 38243131, Free PMC Article
  2. Multiple acyl-CoA dehydrogenase deficiency kills Mycobacterium tuberculosis in vitro and during infection. Beites T, et al. Nat Commun, 2021 Nov 15. PMID 34782606, Free PMC Article
  3. Redox proteomic identification of oxidized cardiac proteins in adriamycin-treated mice. Chen Y, et al. Free Radic Biol Med, 2006 Nov 1. PMID 17023274
  4. Genetic control of neutrophil superoxide production in diabetes-resistant ALR/Lt mice. Mathews CE, et al. Free Radic Biol Med, 2002 Apr 15. PMID 11937300
  5. PHOG, a candidate gene for involvement in the short stature of Turner syndrome. Ellison JW, et al. Hum Mol Genet, 1997 Aug. PMID 9259282

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. An ETFDH-driven metabolon supports OXPHOS efficiency in skeletal muscle by regulating coenzyme Q homeostasis.
    Title: An ETFDH-driven metabolon supports OXPHOS efficiency in skeletal muscle by regulating coenzyme Q homeostasis.
  2. Multiple acyl-CoA dehydrogenase deficiency kills Mycobacterium tuberculosis in vitro and during infection.
    Title: Multiple acyl-CoA dehydrogenase deficiency kills Mycobacterium tuberculosis in vitro and during infection.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables 4 iron, 4 sulfur cluster binding ISO
Inferred from Sequence Orthology
more info
  
enables electron transfer activity ISO
Inferred from Sequence Orthology
more info
  
enables electron transfer activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables electron-transferring-flavoprotein dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables electron-transferring-flavoprotein dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables electron-transferring-flavoprotein dehydrogenase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables iron-sulfur cluster binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables quinone binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquinone binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquinone binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in electron transport chain IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in electron transport chain ISO
Inferred from Sequence Orthology
more info
  
involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase ISO
Inferred from Sequence Orthology
more info
  
involved_in respiratory electron transport chain IEA
Inferred from Electronic Annotation
more info
  
involved_in response to oxidative stress IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of mitochondrial electron transfer flavoprotein complex TAS
Traceable Author Statement
more info
 PubMed 
located_in mitochondrial inner membrane HDA PubMed 
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial
Names
ETF dehydrogenase
ETF-QO
ETF-ubiquinone oxidoreductase
NP_080070.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025794.2 → NP_080070.2  electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_080070.2

    Status: VALIDATED

    Source sequence(s)
    AK141684, AK152624, BE848473
    Consensus CDS
    CCDS17418.1
    UniProtKB/Swiss-Prot
    Q3U7K2, Q8BK82, Q921G7, Q9DCT9
    UniProtKB/TrEMBL
    Q6PF96
    Related
    ENSMUSP00000029386.8, ENSMUST00000029386.14
    Conserved Domains (3) summary
    COG0644
    Location:66 → 528
    FixC; Dehydrogenase (flavoprotein) [Energy production and conversion]
    pfam05187
    Location:511 → 614
    ETF_QO; Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S
    cl21454
    Location:67 → 261
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    79511095..79536074 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q921G7.1 GenPept UniProtKB/Swiss-Prot:Q921G7

Gene LinkOut

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