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Ctnnbl1 catenin, beta like 1 [ Mus musculus (house mouse) ]

Gene ID: 66642, updated on 17-Aug-2024

Summary

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Official Symbol
Ctnnbl1provided by MGI
Official Full Name
catenin, beta like 1provided by MGI
Primary source
MGI:MGI:1913892
See related
Ensembl:ENSMUSG00000027649 AllianceGenome:MGI:1913892
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NAP; P14L; NYD-SP19; 5730471K09Rik
Summary
Predicted to enable enzyme binding activity. Predicted to be involved in positive regulation of apoptotic process and somatic diversification of immunoglobulins. Predicted to act upstream of or within apoptotic process. Predicted to be located in centrosome; cytosol; and nucleoplasm. Predicted to be part of Prp19 complex and spliceosomal complex. Is expressed in cerebral cortex ventricular layer; embryo; limb; and limb mesenchyme. Human ortholog(s) of this gene implicated in colorectal cancer and morbid obesity. Orthologous to human CTNNBL1 (catenin beta like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 25.7), CNS E11.5 (RPKM 19.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 H1; 2 78.4 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (157579321..157733823)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (157737401..157891903)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 25407 Neighboring gene STARR-positive B cell enhancer ABC_E2055 Neighboring gene predicted gene, 23463 Neighboring gene STARR-seq mESC enhancer starr_06218 Neighboring gene STARR-seq mESC enhancer starr_06220 Neighboring gene STARR-seq mESC enhancer starr_06222 Neighboring gene ubiquitin-conjugating enzyme E2I pseudogene Neighboring gene V-set and transmembrane domain containing 2-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cutting edge: CTNNBL1 is dispensable for Ig class switch recombination. Han L, et al. J Immunol, 2010 Aug 1. PMID 20585033, Free PMC Article
  2. Deficiency in spliceosome-associated factor CTNNBL1 does not affect ongoing cell cycling but delays exit from quiescence and results in embryonic lethality in mice. Chandra A, et al. Cell Cycle, 2013 Mar 1. PMID 23343763, Free PMC Article
  3. Sequence, gene structure, and expression pattern of CTNNBL1, a minor-class intron-containing gene--evidence for a role in apoptosis. Jabbour L, et al. Genomics, 2003 Mar. PMID 12659813
  4. Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse. Korinek V, et al. Mol Cell Biol, 1998 Mar. PMID 9488439, Free PMC Article
  5. CTNNBL1 is a novel nuclear localization sequence-binding protein that recognizes RNA-splicing factors CDC5L and Prp31. Ganesh K, et al. J Biol Chem, 2011 May 13. PMID 21385873, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CTNNBL1 plays no essential role in cycling cells but does fulfill an evolutionarily conserved function in helping cells to undergo efficient exit from quiescence following activation.
    Title: Deficiency in spliceosome-associated factor CTNNBL1 does not affect ongoing cell cycling but delays exit from quiescence and results in embryonic lethality in mice.
  2. CTNNBL1 is a novel nuclear localization sequence-binding protein that recognizes RNA-splicing factors CDC5L and Prp31
    Title: CTNNBL1 is a novel nuclear localization sequence-binding protein that recognizes RNA-splicing factors CDC5L and Prp31.
  3. Normal levels of immunoglobulin class switch recombination (CSR) factors are found in DTNNBL1-deficient cells, indicating that CTNNBL1 is dispensable for CSR.
    Title: Cutting edge: CTNNBL1 is dispensable for Ig class switch recombination.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (3)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ21108

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within adaptive immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within apoptotic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in somatic diversification of immunoglobulins ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Prp19 complex ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 PubMed 
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of spliceosomal complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
beta-catenin-like protein 1
Names
nuclear protein NAP
nuclear-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025680.4 → NP_079956.3  beta-catenin-like protein 1

    See identical proteins and their annotated locations for NP_079956.3

    Status: VALIDATED

    Source sequence(s)
    AK145598, AL663092, AL669961
    Consensus CDS
    CCDS16982.1
    UniProtKB/Swiss-Prot
    Q3UL41, Q80X64, Q8VHE3, Q9CWL8
    UniProtKB/TrEMBL
    Q3UKS4
    Related
    ENSMUSP00000029178.7, ENSMUST00000029178.7
    Conserved Domains (2) summary
    cd00020
    Location:125 → 227
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam08216
    Location:57 → 159
    CTNNBL; Catenin-beta-like, Arm-motif containing nuclear

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    157579321..157733823
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500022.3 → XP_006500085.1  beta-catenin-like protein 1 isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CWL8.1 GenPept UniProtKB/Swiss-Prot:Q9CWL8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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