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Ska1 spindle and kinetochore associated complex subunit 1 [ Mus musculus (house mouse) ]

Gene ID: 66468, updated on 2-Nov-2024

Summary

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Official Symbol
Ska1provided by MGI
Official Full Name
spindle and kinetochore associated complex subunit 1provided by MGI
Primary source
MGI:MGI:1913718
See related
Ensembl:ENSMUSG00000036223 AllianceGenome:MGI:1913718
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2810433K01Rik
Summary
Predicted to enable microtubule binding activity. Involved in establishment of meiotic spindle orientation and spindle assembly involved in female meiosis. Located in meiotic spindle. Is expressed in cerebral cortex subventricular zone and genitourinary system. Orthologous to human SKA1 (spindle and kinetochore associated complex subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in liver E14 (RPKM 7.0), liver E14.5 (RPKM 5.2) and 10 other tissues See more
Orthologs
human all
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Genomic context

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See Ska1 in Genome Data Viewer
Location:
18 E2; 18 50.67 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (74328370..74340889, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (74195299..74207818, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32801 Neighboring gene STARR-seq mESC enhancer starr_45002 Neighboring gene predicted gene, 57658 Neighboring gene STARR-positive B cell enhancer ABC_E1520 Neighboring gene STARR-seq mESC enhancer starr_45003 Neighboring gene STARR-seq mESC enhancer starr_45004 Neighboring gene STARR-positive B cell enhancer ABC_E2512 Neighboring gene CXXC finger protein 1 Neighboring gene ribosomal protein L10A pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. SKA1 over-expression promotes centriole over-duplication, centrosome amplification and prostate tumourigenesis. Li J, et al. J Pathol, 2014 Oct. PMID 24827423
  2. Whole genome functional analysis identifies novel components required for mitotic spindle integrity in human cells. Rines DR, et al. Genome Biol, 2008. PMID 18302737, Free PMC Article
  3. Localization and function of the Ska complex during mouse oocyte meiotic maturation. Zhang QH, et al. Cell Cycle, 2012 Mar 1. PMID 22336914
  4. A blueprint for kinetochores - new insights into the molecular mechanics of cell division. Lampert F, et al. Nat Rev Mol Cell Biol, 2011 Jun 2. PMID 21633384
  5. Molecular Profiling Reveals Involvement of ESCO2 in Intermediate Progenitor Cell Maintenance in the Developing Mouse Cortex. Ulmke PA, et al. Stem Cell Reports, 2021 Apr 13. PMID 33798452, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ska1 over-expression promotes tumourigenesis
    Title: SKA1 over-expression promotes centriole over-duplication, centrosome amplification and prostate tumourigenesis.
  2. The Ska1 subunit was only localized on spindle microtubules from the Pro-MI to MII stages in mouse oocyte meiosis and knockdown by Morpholino injection into mouse oocytes resulted in spindle movement defects and enlarged polar bodies.
    Title: Localization and function of the Ska complex during mouse oocyte meiotic maturation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in attachment of mitotic spindle microtubules to kinetochore ISO
Inferred from Sequence Orthology
more info
  
involved_in attachment of mitotic spindle microtubules to kinetochore ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment of meiotic spindle orientation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitotic metaphase chromosome alignment ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitotic sister chromatid segregation ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic sister chromatid segregation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of mitotic spindle assembly checkpoint signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of microtubule polymerization or depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of microtubule polymerization or depolymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of microtubule polymerization or depolymerization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in spindle assembly involved in female meiosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in kinetochore NAS
Non-traceable Author Statement
more info
 PubMed 
located_in meiotic spindle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitotic spindle ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of outer kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of outer kinetochore ISO
Inferred from Sequence Orthology
more info
  
part_of outer kinetochore ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in spindle microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle microtubule ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
SKA complex subunit 1
Names
spindle and kinetochore-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164355.1 → NP_001157827.1  SKA complex subunit 1

    See identical proteins and their annotated locations for NP_001157827.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC133186, AK013233, AK021226, CJ069399
    Consensus CDS
    CCDS29341.1
    UniProtKB/Swiss-Prot
    A0A0R4J0M5, Q005W7, Q8VE34, Q9CPV1, Q9CYW9
    Related
    ENSMUSP00000137357.2, ENSMUST00000177604.2
    Conserved Domains (1) summary
    pfam07160
    Location:16 → 245
    DUF1395; Protein of unknown function (DUF1395)

  2. NM_025581.4 → NP_079857.3  SKA complex subunit 1

    See identical proteins and their annotated locations for NP_079857.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC133186, AK006442
    Consensus CDS
    CCDS29341.1
    UniProtKB/Swiss-Prot
    A0A0R4J0M5, Q005W7, Q8VE34, Q9CPV1, Q9CYW9
    Related
    ENSMUSP00000049156.9, ENSMUST00000040188.16
    Conserved Domains (1) summary
    pfam07160
    Location:16 → 245
    DUF1395; Protein of unknown function (DUF1395)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    74328370..74340889 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CPV1.3 GenPept UniProtKB/Swiss-Prot:Q9CPV1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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