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Dctpp1 dCTP pyrophosphatase 1 [ Mus musculus (house mouse) ]

Gene ID: 66422, updated on 2-Nov-2024

Summary

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Official Symbol
Dctpp1provided by MGI
Official Full Name
dCTP pyrophosphatase 1provided by MGI
Primary source
MGI:MGI:1913672
See related
Ensembl:ENSMUSG00000042462 AllianceGenome:MGI:1913672
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RS21-C6; 2410015N17Rik
Summary
Enables several functions, including identical protein binding activity; magnesium ion binding activity; and pyrimidine deoxyribonucleotide binding activity. Involved in nucleoside triphosphate catabolic process. Located in cytosol. Is expressed in several structures, including brain ventricular layer; gut; jaw; lung; and vertebral axis musculature. Orthologous to human DCTPP1 (dCTP pyrophosphatase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 40.4), liver E14.5 (RPKM 38.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Dctpp1 in Genome Data Viewer
Location:
7 F3; 7 69.42 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126856131..126859839, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (127256959..127260667, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_20176 Neighboring gene predicted gene 4532 Neighboring gene zinc finger protein 553 Neighboring gene STARR-seq mESC enhancer starr_20179 Neighboring gene STARR-positive B cell enhancer ABC_E6605 Neighboring gene zinc finger protein 771 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134404258-134404441 Neighboring gene selenophosphate synthetase 2 Neighboring gene ribosomal protein, large, P1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mouse RS21-C6 is a mammalian 2'-deoxycytidine 5'-triphosphate pyrophosphohydrolase that prefers 5-iodocytosine. Nonaka M, et al. FEBS J, 2009 Mar. PMID 19220460
  2. Crystal structure of RS21-C6, involved in nucleoside triphosphate pyrophosphohydrolysis. Wu B, et al. J Mol Biol, 2007 Apr 13. PMID 17320107
  3. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
  4. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203
  5. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Several key residues involved in the substrate binding of RS21-C6 have been identified.
    Title: Crystal structure of RS21-C6, involved in nucleoside triphosphate pyrophosphohydrolysis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables dCTP diphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dCTP diphosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables dCTP diphosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleoside triphosphate diphosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleoside triphosphate diphosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables pyrimidine deoxyribonucleotide binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables pyrophosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA protection IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA protection ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA protection ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in dCTP catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dCTP catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in dCTP catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleoside triphosphate catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nucleoside triphosphate catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
NOT located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
NOT located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dCTP pyrophosphatase 1
Names
XTP3-transactivated gene A protein homolog
dCTPase 1
deoxycytidine-triphosphatase 1
NP_075692.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023203.1 → NP_075692.1  dCTP pyrophosphatase 1

    See identical proteins and their annotated locations for NP_075692.1

    Status: PROVISIONAL

    Source sequence(s)
    AF110764
    Consensus CDS
    CCDS21862.1
    UniProtKB/Swiss-Prot
    Q9QY93
    Related
    ENSMUSP00000047845.5, ENSMUST00000035276.5
    Conserved Domains (1) summary
    cd11537
    Location:35 → 125
    NTP-PPase_RS21-C6_like; Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    126856131..126859839 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QY93.1 GenPept UniProtKB/Swiss-Prot:Q9QY93

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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