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Sarnp SAP domain containing ribonucleoprotein [ Mus musculus (house mouse) ]

Gene ID: 66118, updated on 2-Nov-2024

Summary

Official Symbol
Sarnpprovided by MGI
Official Full Name
SAP domain containing ribonucleoproteinprovided by MGI
Primary source
MGI:MGI:1913368
See related
Ensembl:ENSMUSG00000078427 AllianceGenome:MGI:1913368
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cip29; 1110005A23Rik
Summary
Enables chromatin binding activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including central nervous system; early conceptus; limb; oocyte; and retina. Orthologous to human SARNP (SAP domain containing ribonucleoprotein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 21.8), liver E14 (RPKM 16.7) and 28 other tissues See more
Orthologs
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Genomic context

See Sarnp in Genome Data Viewer
Location:
10 D3; 10 77.16 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (128657633..128713507)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128821764..128877638)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene matrix metallopeptidase 19 Neighboring gene transmembrane protein 198b Neighboring gene STARR-positive B cell enhancer ABC_E1817 Neighboring gene DnaJ heat shock protein family (Hsp40) member C14 Neighboring gene STARR-positive B cell enhancer ABC_E74 Neighboring gene ORM1-like 2 (S. cerevisiae) Neighboring gene STARR-positive B cell enhancer ABC_E10662 Neighboring gene growth differentiation factor 11 Neighboring gene STARR-positive B cell enhancer ABC_E2975 Neighboring gene CD63 antigen

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1)  1 citation
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasmic ribonucleoprotein granule IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription export complex ISO
Inferred from Sequence Orthology
more info
 
part_of transcription export complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
SAP domain-containing ribonucleoprotein
Names
nuclear protein Hcc-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359403.1NP_001346332.1  SAP domain-containing ribonucleoprotein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AA790241, AA881913, AC122380, AC131081, BY391953, CF949496, CJ053601, DV045727
    UniProtKB/TrEMBL
    B7ZWI2
    Conserved Domains (2) summary
    pfam02037
    Location:842
    SAP; SAP domain
    cl27333
    Location:797
    PARP_reg; Poly(ADP-ribose) polymerase, regulatory domain
  2. NM_001359404.1NP_001346333.1  SAP domain-containing ribonucleoprotein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AA790241, AA881913, AC122380, AC131081, BE847644, BY391953, CF949496, CJ053601, DV045727
    Conserved Domains (1) summary
    smart00513
    Location:842
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
  3. NM_001359405.1NP_001346334.1  SAP domain-containing ribonucleoprotein isoform 4

    Status: VALIDATED

    Source sequence(s)
    AA790241, AA881913, AC122380, AC131081, AI182967, BY391953, CF949496, CJ053601, DV045727
    Conserved Domains (2) summary
    pfam02037
    Location:842
    SAP; SAP domain
    cl27333
    Location:797
    PARP_reg; Poly(ADP-ribose) polymerase, regulatory domain
  4. NM_001359406.1NP_001346335.1  SAP domain-containing ribonucleoprotein isoform 5

    Status: VALIDATED

    Source sequence(s)
    AA790241, AA881913, AC122380, AC131081, BY391953, CF949496, CJ053601, DV045727, W98278
    Consensus CDS
    CCDS88117.1
    UniProtKB/TrEMBL
    A0A1W2P7G2
    Conserved Domains (1) summary
    PTZ00347
    Location:1074
    PTZ00347; phosphomethylpyrimidine kinase; Provisional
  5. NM_001359407.1NP_001346336.1  SAP domain-containing ribonucleoprotein isoform 5

    Status: VALIDATED

    Source sequence(s)
    AA790241, AA881913, AC122380, AC131081, BF147077, BY391953, CF949496, CJ053601, DV045727
    Consensus CDS
    CCDS88117.1
    UniProtKB/TrEMBL
    A0A1W2P7G2
    Related
    ENSMUSP00000151656.2, ENSMUST00000219512.2
    Conserved Domains (1) summary
    PTZ00347
    Location:1074
    PTZ00347; phosphomethylpyrimidine kinase; Provisional
  6. NM_025364.3NP_079640.1  SAP domain-containing ribonucleoprotein isoform 1

    See identical proteins and their annotated locations for NP_079640.1

    Status: VALIDATED

    Source sequence(s)
    AA790241, AA881913, AC122380, AC131081, AK003453
    Consensus CDS
    CCDS36092.1
    UniProtKB/Swiss-Prot
    Q3UJZ4, Q9CU18, Q9D1J3
    UniProtKB/TrEMBL
    B2RXM7
    Related
    ENSMUSP00000100863.3, ENSMUST00000105230.4
    Conserved Domains (1) summary
    pfam02037
    Location:842
    SAP; SAP domain

RNA

  1. NR_153109.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AA790241, AA881913, AC122380, AC131081, BC094393, BY391953, CF949496
    Related
    ENSMUST00000220381.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    128657633..128713507
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)