Txndc12 thioredoxin domain containing 12 (endoplasmic reticulum) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Txndc12provided by MGI
Official Full Name: thioredoxin domain containing 12 (endoplasmic reticulum)provided by MGI
Primary source: MGI:MGI:1913323
See related: Ensembl:ENSMUSG00000028567 AllianceGenome:MGI:1913323
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ERp16; ERp19; 0610040B21Rik
Summary: Predicted to enable protein-disulfide reductase activity. Predicted to be involved in negative regulation of cell death. Predicted to act upstream of or within negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. Located in endoplasmic reticulum. Is expressed in several structures, including alimentary system; brain; cranium; eye; and respiratory system. Orthologous to human TXNDC12 (thioredoxin domain containing 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in placenta adult (RPKM 28.4), limb E14.5 (RPKM 22.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 C7; 4 50.64 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (108691875..108719317)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (108834678..108862120)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ERp16 mediates disulfide bond formation in the ER and plays an important role in cellular defense against prolonged ER stress
Title: ERp16, an endoplasmic reticulum-resident thiol-disulfide oxidoreductase: biochemical properties and role in apoptosis induced by endoplasmic reticulum stress.
both ERp19 and ERp46 and their respective mRNAs are highly expressed in the liver as compared with other tissues
Title: ERp19 and ERp46, new members of the thioredoxin family of endoplasmic reticulum proteins.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein-disulfide reductase (glutathione) activity	ISO Inferred from Sequence Orthology more info
enables protein-disulfide reductase (glutathione) activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein-disulfide reductase activity	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum lumen	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum lumen	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: thioredoxin domain-containing protein 12

Names: ER protein 19; endoplasmic reticulum protein ERp19; endoplasmic reticulum resident protein 19; ortholog of endoplasmic reticulum thioredoxin superfamily member, 18 kDa TLP19; thioredoxin-like protein p19

NP_079610.1

EC 1.8.4.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025334.3 → NP_079610.1 thioredoxin domain-containing protein 12 precursor

See identical proteins and their annotated locations for NP_079610.1

Status: PROVISIONAL

Source sequence(s)

AL607070

Consensus CDS

CCDS18457.1

UniProtKB/Swiss-Prot

Q53YN1, Q9CQU0

Related

ENSMUSP00000030296.9, ENSMUST00000030296.9

Conserved Domains (1) summary

cd02959
Location:34 → 150

ERp19; Endoplasmic reticulum protein 19 (ERp19) family; ERp19 is also known as ERp18, a protein located in the ER containing one redox active TRX domain. Denaturation studies indicate that the reduced form is more stable than the oxidized form, suggesting that ...