U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Emc6 ER membrane protein complex subunit 6 [ Mus musculus (house mouse) ]

Gene ID: 66048, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Emc6provided by MGI
Official Full Name
ER membrane protein complex subunit 6provided by MGI
Primary source
MGI:MGI:1913298
See related
Ensembl:ENSMUSG00000047260 AllianceGenome:MGI:1913298
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tmem93; 0610009E20Rik; 0610025L18Rik
Summary
Predicted to contribute to membrane insertase activity. Predicted to be involved in autophagosome assembly; protein insertion into ER membrane by stop-transfer membrane-anchor sequence; and tail-anchored membrane protein insertion into ER membrane. Predicted to be located in endoplasmic reticulum membrane and omegasome membrane. Predicted to be part of EMC complex. Is expressed in several structures, including bladder; central nervous system; liver; pancreas; and skin. Orthologous to human EMC6 (ER membrane protein complex subunit 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in adrenal adult (RPKM 42.4), mammary gland adult (RPKM 30.8) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Emc6 in Genome Data Viewer
Location:
11 B4; 11 45.25 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (73066329..73067868, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (73175503..73177042, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene integrin alpha E, epithelial-associated Neighboring gene histone H3 associated protein kinase Neighboring gene STARR-seq mESC enhancer starr_29929 Neighboring gene purinergic receptor P2X, ligand-gated ion channel, 5 Neighboring gene STARR-positive B cell enhancer ABC_E1141 Neighboring gene Tax1 (human T cell leukemia virus type I) binding protein 3 Neighboring gene cystinosis, nephropathic

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Ad5-EMC6 mediates antitumor activity in gastric cancer cells through the mitochondrial apoptosis pathway. Li R, et al. Biochem Biophys Res Commun, 2019 Jun 4. PMID 30982575
  2. The ER membrane protein complex is a transmembrane domain insertase. Guna A, et al. Science, 2018 Jan 26. PMID 29242231, Free PMC Article
  3. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
  4. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. Murn J, et al. Genes Dev, 2015 Mar 1. PMID 25737280, Free PMC Article
  5. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to membrane insertase activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to membrane insertase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagosome assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in autophagosome assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in protein insertion into ER membrane by stop-transfer membrane-anchor sequence ISO
Inferred from Sequence Orthology
more info
  
involved_in protein insertion into ER membrane by stop-transfer membrane-anchor sequence ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in tail-anchored membrane protein insertion into ER membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in tail-anchored membrane protein insertion into ER membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of EMC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of EMC complex ISO
Inferred from Sequence Orthology
more info
  
part_of EMC complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in omegasome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in omegasome membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
ER membrane protein complex subunit 6
Names
transmembrane protein 93

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168470.1 → NP_001161942.1  ER membrane protein complex subunit 6

    See identical proteins and their annotated locations for NP_001161942.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL670399, DV661517
    Consensus CDS
    CCDS24999.1
    UniProtKB/Swiss-Prot
    Q9CQ41, Q9CQW0
    Related
    ENSMUSP00000104120.2, ENSMUST00000108480.2
    Conserved Domains (1) summary
    pfam07019
    Location:25 → 101
    Rab5ip; Rab5-interacting protein (Rab5ip)

  2. NM_025318.3 → NP_079594.1  ER membrane protein complex subunit 6

    See identical proteins and their annotated locations for NP_079594.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK003198, AK004149, AL670399
    Consensus CDS
    CCDS24999.1
    UniProtKB/Swiss-Prot
    Q9CQ41, Q9CQW0
    Related
    ENSMUSP00000060892.4, ENSMUST00000054952.4
    Conserved Domains (1) summary
    pfam07019
    Location:25 → 101
    Rab5ip; Rab5-interacting protein (Rab5ip)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    73066329..73067868 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQW0.1 GenPept UniProtKB/Swiss-Prot:Q9CQW0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools