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OCM oncomodulin [ Homo sapiens (human) ]

Gene ID: 654231, updated on 2-Nov-2024

Summary

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Official Symbol
OCMprovided by HGNC
Official Full Name
oncomodulinprovided by HGNC
Primary source
HGNC:HGNC:8105
See related
Ensembl:ENSG00000122543 MIM:164795; AllianceGenome:HGNC:8105
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OM; OCM1; ONCM
Summary
Oncomodulin is a high-affinity calcium ion-binding protein. It belongs to the superfamily of calmodulin proteins, also known as the EF-hand proteins. Oncomodulin is an oncodevelopmental protein found in early embryonic cells in the placenta and also in tumors. [provided by RefSeq, Jul 2008]
Annotation information
Note: There are two oncomodulin-like loci on chromosome 7 (GeneIDs 4951 and 654231). The nomenclature for the p and q arm locations was modified to agree with reports (including PMID: 1559707) that place the OCM gene on the p arm. [18 Jun 2007]
Expression
Low expression observed in reference dataset See more
Orthologs
mouse all
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Genomic context

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See OCM in Genome Data Viewer
Location:
7p22.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (5859718..5886363)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (5977469..6004117)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (5899349..5925994)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ring finger protein 216 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5775501-5776002 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5776003-5776502 Neighboring gene microRNA 6874 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17930 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25612 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5871051-5871551 Neighboring gene zinc finger protein 815, pseudogene Neighboring gene Sharpr-MPRA regulatory region 1711 Neighboring gene RNA, 7SL, cytoplasmic 556, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25613 Neighboring gene nonconserved acetylation island sequence 61 enhancer Neighboring gene CCZ1 homolog, vacuolar protein trafficking and biogenesis associated Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5987517-5988017 Neighboring gene radial spoke head 10 homolog B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:6047103-6047794 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25614 Neighboring gene PMS1 homolog 2, mismatch repair system component

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Long-distance axon regeneration in the mature optic nerve: contributions of oncomodulin, cAMP, and pten gene deletion. Kurimoto T, et al. J Neurosci, 2010 Nov 17. PMID 21084621, Free PMC Article
  2. The Ca2+(-)binding proteins parvalbumin and oncomodulin and their genes: new structural and functional findings. Pauls TL, et al. Biochim Biophys Acta, 1996 Apr 10. PMID 8611623
  3. Disulfide-linked dimer of oncomodulin: comparison to calmodulin. Mutus B, et al. Biochemistry, 1988 Jul 26. PMID 3179268
  4. Oncomodulin, an EF-Hand Ca2+ Buffer, Is Critical for Maintaining Cochlear Function in Mice. Tong B, et al. J Neurosci, 2016 Feb 3. PMID 26843644, Free PMC Article
  5. Human alpha and beta parvalbumins. Structure and tissue-specific expression. Föhr UG, et al. Eur J Biochem, 1993 Aug 1. PMID 8354278

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deletion of oncomodulin in outer hair cells, leads to a progressive hearing loss in transgenic mice.
    Title: Oncomodulin, an EF-Hand Ca2+ Buffer, Is Critical for Maintaining Cochlear Function in Mice.
  2. Data indicate taht candidate genes ACTB, BZW, OCM, MACC1, NXPH1, PRPS1L1, RAC1 and RPA3, which lie within the DFNB90 region, were sequenced and no potentially causal variants were identified.
    Title: Novel autosomal recessive nonsyndromic hearing impairment locus DFNB90 maps to 7p22.1-p15.3.
  3. Ocm plays a central role in inflammation-induced regeneration in the optic nerve.
    Title: Long-distance axon regeneration in the mature optic nerve: contributions of oncomodulin, cAMP, and pten gene deletion.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC97453, MGC97465, MGC97477, MGC142264, MGC142266

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
oncomodulin-1
Names
beta parvalbumin
hCG18255
parvalbumin beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001097622.2 → NP_001091091.1  oncomodulin-1 isoform a

    See identical proteins and their annotated locations for NP_001091091.1

    Status: VALIDATED

    Source sequence(s)
    BC113704, CB045979, DB339645
    Consensus CDS
    CCDS43548.1
    UniProtKB/Swiss-Prot
    B9EJH7, P0CE72
    Related
    ENSP00000242104.5, ENST00000242104.6
    Conserved Domains (1) summary
    cd16255
    Location:9 → 109
    EFh_parvalbumin_beta; EF-hand, calcium binding motif, found in beta-parvalbumin

  2. NM_001391990.1 → NP_001378919.1  oncomodulin-1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC004983
    Consensus CDS
    CCDS43548.1
    UniProtKB/Swiss-Prot
    B9EJH7, P0CE72
    Conserved Domains (1) summary
    cd16255
    Location:9 → 109
    EFh_parvalbumin_beta; EF-hand, calcium binding motif, found in beta-parvalbumin

  3. NM_001391991.1 → NP_001378920.1  oncomodulin-1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC004983
    Conserved Domains (2) summary
    cd16251
    Location:5 → 34
    EFh_parvalbumin_like; EF-hand motif [structural motif]
    cl25356
    Location:1 → 71
    EFh_parvalbumin_like; EF-hand, calcium binding motif, found in parvalbumin-like EF-hand family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    5859718..5886363
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420752.1 → XP_047276708.1  oncomodulin-1 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    5977469..6004117
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054358849.1 → XP_054214824.1  oncomodulin-1 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0CE72.1 GenPept UniProtKB/Swiss-Prot:P0CE72

Gene LinkOut

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