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PSG10P pregnancy specific beta-1-glycoprotein 10, pseudogene [ Homo sapiens (human) ]

Gene ID: 653492, updated on 22-Oct-2024

Summary

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Official Symbol
PSG10Pprovided by HGNC
Official Full Name
pregnancy specific beta-1-glycoprotein 10, pseudogeneprovided by HGNC
Primary source
HGNC:HGNC:9515
See related
Ensembl:ENSG00000291235 MIM:176399; AllianceGenome:HGNC:9515
Gene type
pseudo
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PSG10; PSG12
Summary
The human pregnancy-specific glycoproteins (PSGs) are a group of molecules that are mainly produced by the placental syncytiotrophoblasts during pregnancy. PSGs comprise a subgroup of the carcinoembryonic antigen (CEA) family, which belongs to the immunoglobulin superfamily. For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009]
Expression
Restricted expression toward placenta (RPKM 7.0) See more
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Genomic context

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See PSG10P in Genome Data Viewer
Location:
19q13.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (42836997..42855718, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (45655941..45674669, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (43341149..43359870, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene CEA cell adhesion molecule pseudogene 6 Neighboring gene PSG8 antisense RNA 1 Neighboring gene pregnancy specific beta-1-glycoprotein 1 Neighboring gene pregnancy specific beta-1-glycoprotein 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Pregnancy-Specific Beta-1-Glycoprotein: The Player of the Game in predicting adverse outcomes in pregnancy. Toprak K, et al. JBRA Assist Reprod, 2023 Jun 22. PMID 36749818, Free PMC Article
  2. Characterization of two allelic variants of a human pregnancy-specific glycoprotein gene. Lei KJ, et al. J Biol Chem, 1993 Aug 15. PMID 8349632
  3. A pregnancy-specific beta 1-glycoprotein, a CEA gene family member, expressed in a human promyelocytic leukemia cell line, HL-60: structures of protein, mRNA and gene. Oikawa S, et al. Biochem Biophys Res Commun, 1989 Sep 15. PMID 2789512
  4. Potential regulatory network in the PSG10P/miR-19a-3p/IL1RAP pathway is possibly involved in preeclampsia pathogenesis. Wang N, et al. J Cell Mol Med, 2019 Feb. PMID 30370628, Free PMC Article
  5. cDNA cloning demonstrates the expression of pregnancy-specific glycoprotein genes, a subgroup of the carcinoembryonic antigen gene family, in fetal liver. Zimmermann W, et al. Biochem Biophys Res Commun, 1989 Sep 29. PMID 2783133

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pregnancy-Specific Beta-1-Glycoprotein: The Player of the Game in predicting adverse outcomes in pregnancy.
    Title: Pregnancy-Specific Beta-1-Glycoprotein: The Player of the Game in predicting adverse outcomes in pregnancy.
  2. A regulatory network in the PSG10P/miR-19a-3p/IL1RAP pathway may contribute to preeclampsia pathogenesis during pregnancy.
    Title: Potential regulatory network in the PSG10P/miR-19a-3p/IL1RAP pathway is possibly involved in preeclampsia pathogenesis.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Other Names

  • pregnancy specific beta-1-glycoprotein 1 pseudogene
  • pregnancy specific beta-1-glycoprotein 12
  • pregnancy specific beta-1-glycoprotein 120
  • pregnancy-specific beta-1 glycoprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_026824.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AC004603, AK309876
    Related
    ENST00000730696.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    42836997..42855718 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    45655941..45674669 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_176809.2: Suppressed sequence

    Description
    NM_176809.2: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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