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Dlgap1 DLG associated protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 65040, updated on 2-Nov-2024

Summary

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Official Symbol
Dlgap1provided by RGD
Official Full Name
DLG associated protein 1provided by RGD
Primary source
RGD:620223
See related
EnsemblRapid:ENSRNOG00000016196 AllianceGenome:RGD:620223
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gkap; DAP-1; rGKAP; SAPAP1; GKAP/SAPAP1
Summary
Enables protein domain specific binding activity. A structural constituent of postsynaptic density. Involved in several processes, including aggresome assembly; protein localization to synapse; and regulation of proteasomal protein catabolic process. Located in postsynaptic membrane. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Orthologous to human DLGAP1 (DLG associated protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 171.0), Lung (RPKM 19.0) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dlgap1 in Genome Data Viewer
Location:
9q38
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (117304144..118173463)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (109857500..110726817)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (118277046..119159807)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480431 Neighboring gene large ribosomal subunit protein eL21-like Neighboring gene A-kinase anchor inhibitor 1 Neighboring gene uncharacterized LOC134480625 Neighboring gene dephospho-CoA kinase domain-containing protein-like Neighboring gene uncharacterized LOC120094814 Neighboring gene uncharacterized LOC102555426 Neighboring gene uncharacterized LOC134480624 Neighboring gene uncharacterized LOC102555570 Neighboring gene uncharacterized LOC120094777 Neighboring gene TGFB-induced factor homeobox 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Crystallization and preliminary X-ray crystallographic analysis of the C-terminal domain of guanylate kinase-associated protein from Rattus norvegicus. Tong J, et al. Acta Crystallogr F Struct Biol Commun, 2014 Jul. PMID 25005096, Free PMC Article
  2. GKAP orchestrates activity-dependent postsynaptic protein remodeling and homeostatic scaling. Shin SM, et al. Nat Neurosci, 2012 Dec. PMID 23143515, Free PMC Article
  3. Differential expression of isoforms of PSD-95 binding protein (GKAP/SAPAP1) during rat brain development. Kawashima N, et al. FEBS Lett, 1997 Dec 1. PMID 9428732
  4. Synamon, a novel neuronal protein interacting with synapse-associated protein 90/postsynaptic density-95-associated protein. Yao I, et al. J Biol Chem, 1999 Sep 24. PMID 10488079
  5. Degradation of postsynaptic scaffold GKAP and regulation of dendritic spine morphology by the TRIM3 ubiquitin ligase in rat hippocampal neurons. Hung AY, et al. PLoS One, 2010 Mar 24. PMID 20352094, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Upon depolarization with high K+, neither the intensity nor distribution of label for GKAP changed, but labeling intensity for Shank at the postsynaptic density increased to ~150% of controls.
    Title: Differential distribution of Shank and GKAP at the postsynaptic density.
  2. The C-terminal helical domain of GKAP from Rattus norvegicus was purified and crystallized as a fusion protein.
    Title: Crystallization and preliminary X-ray crystallographic analysis of the C-terminal domain of guanylate kinase-associated protein from Rattus norvegicus.
  3. Phosphorylated serine residues in several of the identified phosphorylation sites were followed by prolines, suggesting prominent involvement of proline directed kinases in the regulation of PSD components.
    Title: Identification of novel phosphorylation sites on postsynaptic density proteins.
  4. Activity-dependent turnover of postsynnaptic density proteins orchestrated by GKAP is critical for homeostatic plasticity.
    Title: GKAP orchestrates activity-dependent postsynaptic protein remodeling and homeostatic scaling.
  5. postsynaptic scaffold GKAP is degraded and dendritic spine morphology is regulated by the TRIM3 ubiquitin ligase in rat hippocampal neurons
    Title: Degradation of postsynaptic scaffold GKAP and regulation of dendritic spine morphology by the TRIM3 ubiquitin ligase in rat hippocampal neurons.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of postsynaptic density IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in aggresome assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in maintenance of postsynaptic density structure IEA
Inferred from Electronic Annotation
more info
  
involved_in modulation of chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of proteasomal protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signaling IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in glutamatergic synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
  
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic density, intracellular component IDA
Inferred from Direct Assay
more info
 PubMed 
located_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic specialization IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
disks large-associated protein 1
Names
PSD-95 binding protein
PSD-95/SAP90-binding protein 1
SAP90/PSD-95-associated protein 1
discs large homolog associated protein 1
guanylate kinase-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304287.1 → NP_001291216.1  disks large-associated protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks three 5' exons, contains an alternate 5' terminal exon, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A8I6AE66
    Related
    ENSRNOP00000072852.1, ENSRNOT00000087592.3
    Conserved Domains (1) summary
    pfam03359
    Location:360 → 692
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  2. NM_022946.3 → NP_075235.3  disks large-associated protein 1 isoform 1

    See identical proteins and their annotated locations for NP_075235.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    O54773, P97836, P97841
    UniProtKB/TrEMBL
    A0A0G2K6T7, A6KF81
    Related
    ENSRNOP00000073938.1, ENSRNOT00000090512.4
    Conserved Domains (1) summary
    pfam03359
    Location:660 → 992
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    117304144..118173463
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039084190.2 → XP_038940118.1  disks large-associated protein 1 isoform X3

    UniProtKB/Swiss-Prot
    O54773, P97836, P97841
    Conserved Domains (1) summary
    pfam03359
    Location:632 → 964
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  2. XM_039084191.2 → XP_038940119.1  disks large-associated protein 1 isoform X4

    UniProtKB/Swiss-Prot
    O54773, P97836, P97841
    UniProtKB/TrEMBL
    A6KF82
    Conserved Domains (1) summary
    pfam03359
    Location:622 → 954
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  3. XM_039084189.2 → XP_038940117.1  disks large-associated protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O54773, P97836, P97841
    UniProtKB/TrEMBL
    A0A0G2K6T7, A6KF81
    Conserved Domains (1) summary
    pfam03359
    Location:660 → 992
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  4. XM_039084188.2 → XP_038940116.1  disks large-associated protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O54773, P97836, P97841
    UniProtKB/TrEMBL
    A0A0G2K6T7, A6KF81
    Conserved Domains (1) summary
    pfam03359
    Location:660 → 992
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  5. XM_017596627.3 → XP_017452116.1  disks large-associated protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O54773, P97836, P97841
    UniProtKB/TrEMBL
    A0A0G2K6T7, A6KF81
    Conserved Domains (1) summary
    pfam03359
    Location:660 → 992
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  6. XM_017596630.3 → XP_017452119.1  disks large-associated protein 1 isoform X2

    UniProtKB/Swiss-Prot
    O54773, P97836, P97841
    UniProtKB/TrEMBL
    G3V849
    Related
    ENSRNOP00000022351.8, ENSRNOT00000022351.10

  7. XM_063267696.1 → XP_063123766.1  disks large-associated protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K6T7, A6KF81

  8. XM_017596628.3 → XP_017452117.1  disks large-associated protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O54773, P97836, P97841
    UniProtKB/TrEMBL
    A0A0G2K6T7, A6KF81
    Conserved Domains (1) summary
    pfam03359
    Location:660 → 992
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  9. XM_063267703.1 → XP_063123773.1  disks large-associated protein 1 isoform X17

  10. XM_063267701.1 → XP_063123771.1  disks large-associated protein 1 isoform X15

  11. XM_039084192.2 → XP_038940120.1  disks large-associated protein 1 isoform X11

    UniProtKB/TrEMBL
    A0A8I5ZYB2
    Conserved Domains (1) summary
    pfam03359
    Location:341 → 673
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  12. XM_063267697.1 → XP_063123767.1  disks large-associated protein 1 isoform X6

  13. XM_008767429.4 → XP_008765651.1  disks large-associated protein 1 isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZYB2
    Related
    ENSRNOP00000084169.2, ENSRNOT00000110426.2
    Conserved Domains (1) summary
    pfam03359
    Location:379 → 711
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  14. XM_063267704.1 → XP_063123774.1  disks large-associated protein 1 isoform X18

  15. XM_063267700.1 → XP_063123770.1  disks large-associated protein 1 isoform X13

  16. XM_063267702.1 → XP_063123772.1  disks large-associated protein 1 isoform X16

  17. XM_039084193.2 → XP_038940121.1  disks large-associated protein 1 isoform X12

    UniProtKB/TrEMBL
    A0A8I5ZYB2, A6KF84
    Conserved Domains (1) summary
    pfam03359
    Location:334 → 666
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  18. XM_063267699.1 → XP_063123769.1  disks large-associated protein 1 isoform X9

  19. XM_008767430.4 → XP_008765652.1  disks large-associated protein 1 isoform X7

    See identical proteins and their annotated locations for XP_008765652.1

    UniProtKB/TrEMBL
    A0A8I6AE66, A6KF83
    Conserved Domains (1) summary
    pfam03359
    Location:362 → 694
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  20. XM_017596631.3 → XP_017452120.1  disks large-associated protein 1 isoform X10

    UniProtKB/TrEMBL
    A0A8I6AE66

  21. XM_008767432.4 → XP_008765654.1  disks large-associated protein 1 isoform X8

    UniProtKB/TrEMBL
    A0A8I6AE66
    Related
    ENSRNOP00000090776.2, ENSRNOT00000119591.2
    Conserved Domains (1) summary
    pfam03359
    Location:352 → 684
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  22. XM_008767433.4 → XP_008765655.1  disks large-associated protein 1 isoform X14

    UniProtKB/TrEMBL
    A0A8I6AE66
    Conserved Domains (1) summary
    pfam03359
    Location:341 → 673
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97836.1 GenPept UniProtKB/Swiss-Prot:P97836

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