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Fgfbp1 fibroblast growth factor binding protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64535, updated on 17-Aug-2024

Summary

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Official Symbol
Fgfbp1provided by RGD
Official Full Name
fibroblast growth factor binding protein 1provided by RGD
Primary source
RGD:621211
See related
EnsemblRapid:ENSRNOG00000003095 AllianceGenome:RGD:621211
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable fibroblast growth factor binding activity. Involved in cell-cell signaling. Predicted to be located in cell surface and extracellular region. Orthologous to human FGFBP1 (fibroblast growth factor binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 127.8), Lung (RPKM 123.4) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Fgfbp1 in Genome Data Viewer
Location:
14q21
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (71316171..71319965)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (67103686..67107492)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (71647429..71650359)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096623 Neighboring gene U7 small nuclear RNA Neighboring gene prominin 1 Neighboring gene APEX nuclease (apurinic/apyrimidinic endonuclease) 2-like 1 Neighboring gene CD38 molecule

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Effects on neurite outgrowth and cell survival of a secreted fibroblast growth factor binding protein upregulated during spinal cord injury. Tassi E, et al. Am J Physiol Regul Integr Comp Physiol, 2007 Aug. PMID 17553847
  2. Tissue distribution and retinoid-mediated downregulation of an FGF-binding protein (FGF-BP) in the rat. Aigner A, et al. Growth Factors, 2000. PMID 10831072
  3. Up-regulation of FGFBP1 signaling contributes to miR-146a-induced angiogenesis in human umbilical vein endothelial cells. Zhu HY, et al. Sci Rep, 2016 Apr 28. PMID 27121396, Free PMC Article
  4. Interactions of multiple heparin binding growth factors with neuropilin-1 and potentiation of the activity of fibroblast growth factor-2. West DC, et al. J Biol Chem, 2005 Apr 8. PMID 15695515
  5. The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair. Beer HD, et al. Oncogene, 2005 Aug 11. PMID 15806171

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables fibroblast growth factor binding IEA
Inferred from Electronic Annotation
more info
  
enables fibroblast growth factor binding ISO
Inferred from Sequence Orthology
more info
  
enables growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell-cell signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in fibroblast growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of fibroblast growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in myoblast proliferation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of myoblast proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell migration involved in sprouting angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of fibroblast growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of fibroblast growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of myoblast proliferation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of myoblast proliferation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell surface IEA
Inferred from Electronic Annotation
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
fibroblast growth factor-binding protein 1
Names
FGF-BP
FGF-BP1
FGF-binding protein 1
FGFBP-1
growth factor-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022603.2 → NP_072125.2  fibroblast growth factor-binding protein 1 precursor

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/Swiss-Prot
    Q9QY10
    UniProtKB/TrEMBL
    A6IJN7, G3V6D7
    Conserved Domains (1) summary
    pfam06473
    Location:15 → 233
    FGF-BP1; FGF binding protein 1 (FGF-BP1)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    71316171..71319965
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006251079.5 → XP_006251141.1  fibroblast growth factor-binding protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q9QY10
    Conserved Domains (1) summary
    pfam06473
    Location:9 → 196
    FGF-BP1; FGF binding protein 1 (FGF-BP1)

  2. XM_006251078.5 → XP_006251140.1  fibroblast growth factor-binding protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006251140.1

    UniProtKB/Swiss-Prot
    Q9QY10
    UniProtKB/TrEMBL
    A6IJN7, G3V6D7
    Related
    ENSRNOP00000004128.3, ENSRNOT00000004128.6
    Conserved Domains (1) summary
    pfam06473
    Location:15 → 233
    FGF-BP1; FGF binding protein 1 (FGF-BP1)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QY10.1 GenPept UniProtKB/Swiss-Prot:Q9QY10

Gene LinkOut

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