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DUS1L dihydrouridine synthase 1 like [ Homo sapiens (human) ]

Gene ID: 64118, updated on 14-Nov-2024

Summary

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Official Symbol
DUS1Lprovided by HGNC
Official Full Name
dihydrouridine synthase 1 likeprovided by HGNC
Primary source
HGNC:HGNC:30086
See related
Ensembl:ENSG00000169718 AllianceGenome:HGNC:30086
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DUS1; PP3111
Summary
Predicted to enable tRNA dihydrouridine synthase activity. Involved in tRNA dihydrouridine synthesis. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in spleen (RPKM 23.4), prostate (RPKM 22.1) and 25 other tissues See more
Orthologs
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Genomic context

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See DUS1L in Genome Data Viewer
Location:
17q25.3
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (82057506..82065804, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (82924664..82932962, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (80015382..80023680, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene DCXR divergent transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:80009332-80010001 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:80022320-80023048 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9188 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9189 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9190 Neighboring gene RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Neighboring gene G protein pathway suppressor 1 Neighboring gene MPRA-validated peak3028 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:80038893-80039778 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:80054421-80055336 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9192 Neighboring gene fatty acid synthase Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9193 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9194 Neighboring gene small nucleolar RNA, C/D box 134 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:80061739-80062652 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:80062653-80063566 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12986 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12987 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12988 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:80065397-80066310 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12989 Neighboring gene coiled-coil domain containing 57 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:80074745-80075652 Neighboring gene uncharacterized LOC124904119

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Human DUS1L catalyzes dihydrouridine modification at tRNA positions 16/17, and DUS1L overexpression perturbs translation. Matsuura J, et al. Commun Biol, 2024 Oct 2. PMID 39354220, Free PMC Article
  2. Transcription-wide mapping of dihydrouridine reveals that mRNA dihydrouridylation is required for meiotic chromosome segregation. Finet O, et al. Mol Cell, 2022 Jan 20. PMID 34798057, Free PMC Article
  3. Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins. Tomkins JE, et al. Proteomics, 2018 May. PMID 29513927, Free PMC Article
  4. The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4. Chen W, et al. Breast Cancer Res Treat, 2023 Oct. PMID 37433992, Free PMC Article
  5. Mutual regulation between OGT and XIAP to control colon cancer cell growth and invasion. Seo HG, et al. Cell Death Dis, 2020 Sep 29. PMID 32994395, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Human DUS1L catalyzes dihydrouridine modification at tRNA positions 16/17, and DUS1L overexpression perturbs translation.
    Title: Human DUS1L catalyzes dihydrouridine modification at tRNA positions 16/17, and DUS1L overexpression perturbs translation.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables tRNA dihydrouridine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA-dihydrouridine16 synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables tRNA-dihydrouridine17 synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in tRNA dihydrouridine synthesis IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like
NP_071439.3
XP_005256450.1
XP_005256451.1
XP_006722351.1
XP_006722352.1
XP_024306636.1
XP_024306637.1
XP_024306638.1
XP_024306639.1
XP_047292475.1
XP_047292476.1
XP_047292477.1
XP_054172862.1
XP_054172863.1
XP_054172864.1
XP_054172865.1
XP_054172866.1
XP_054172867.1
XP_054172868.1
XP_054172869.1
XP_054172870.1
XP_054172871.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022156.5 → NP_071439.3  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like

    See identical proteins and their annotated locations for NP_071439.3

    Status: VALIDATED

    Source sequence(s)
    AC135056, BC062566, BC064918, DB481578
    Consensus CDS
    CCDS32775.1
    UniProtKB/Swiss-Prot
    A6NHV4, Q6P1R4, Q96AI3
    Related
    ENSP00000303515.5, ENST00000306796.10
    Conserved Domains (2) summary
    cd02801
    Location:18 → 250
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
    cl27070
    Location:395 → 429
    DUF702; Domain of unknown function (DUF702)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    82057506..82065804 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006722289.3 → XP_006722352.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X6

    Conserved Domains (3) summary
    TIGR01623
    Location:377 → 412
    put_zinc_LRP1; putative zinc finger domain, LRP1 type
    cd02801
    Location:18 → 233
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
    pfam01207
    Location:20 → 290
    Dus; Dihydrouridine synthase (Dus)

  2. XM_006722288.3 → XP_006722351.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X4

    Conserved Domains (2) summary
    cd02801
    Location:18 → 233
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
    pfam01207
    Location:20 → 290
    Dus; Dihydrouridine synthase (Dus)

  3. XM_024450869.2 → XP_024306637.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X2

    Conserved Domains (1) summary
    cd02801
    Location:18 → 215
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...

  4. XM_005256394.3 → XP_005256451.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X8

    Conserved Domains (2) summary
    cd02801
    Location:18 → 250
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
    pfam01207
    Location:20 → 307
    Dus; Dihydrouridine synthase (Dus)

  5. XM_005256393.3 → XP_005256450.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X3

    Conserved Domains (2) summary
    cd02801
    Location:18 → 250
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
    pfam01207
    Location:20 → 307
    Dus; Dihydrouridine synthase (Dus)

  6. XM_024450871.2 → XP_024306639.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X7

    Conserved Domains (1) summary
    cd02801
    Location:18 → 232
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...

  7. XM_024450870.2 → XP_024306638.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X5

    Conserved Domains (2) summary
    cd02801
    Location:18 → 232
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
    cl27070
    Location:412 → 447
    DUF702; Domain of unknown function (DUF702)

  8. XM_024450868.2 → XP_024306636.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X1

    Conserved Domains (1) summary
    cd02801
    Location:18 → 232
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...

  9. XM_047436519.1 → XP_047292475.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X1

  10. XM_047436520.1 → XP_047292476.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X9

  11. XM_047436521.1 → XP_047292477.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X9

RNA

  1. XR_002958052.2 RNA Sequence

    Related
    ENST00000582529.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    82924664..82932962 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054316888.1 → XP_054172863.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X2

  2. XM_054316894.1 → XP_054172869.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X8

  3. XM_054316889.1 → XP_054172864.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X3

  4. XM_054316887.1 → XP_054172862.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X1

  5. XM_054316892.1 → XP_054172867.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X6

  6. XM_054316890.1 → XP_054172865.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X4

  7. XM_054316893.1 → XP_054172868.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X7

  8. XM_054316891.1 → XP_054172866.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X5

  9. XM_054316895.1 → XP_054172870.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X9

  10. XM_054316896.1 → XP_054172871.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X9

RNA

  1. XR_008484870.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P1R4.1 GenPept UniProtKB/Swiss-Prot:Q6P1R4

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