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TSPYL2 TSPY like 2 [ Homo sapiens (human) ]

Gene ID: 64061, updated on 3-Nov-2024

Summary

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Official Symbol
TSPYL2provided by HGNC
Official Full Name
TSPY like 2provided by HGNC
Primary source
HGNC:HGNC:24358
See related
Ensembl:ENSG00000184205 MIM:300564; AllianceGenome:HGNC:24358
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CDA1; CTCL; NP79; TSPX; CINAP; DENTT; SE204; HRIHFB2216
Summary
This gene encodes a member of the testis-specific protein Y-encoded, TSPY-like/SET/nucleosome assembly protein-1 superfamily. The encoded protein is localized to the nucleolus where it functions in chromatin remodeling and as an inhibitor of cell-cycle progression. This protein may play a role in the suppression of tumor growth. [provided by RefSeq, Sep 2009]
Expression
Broad expression in ovary (RPKM 45.2), testis (RPKM 42.8) and 24 other tissues See more
Orthologs
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Genomic context

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See TSPYL2 in Genome Data Viewer
Location:
Xp11.22
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (53082367..53088540)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (52368603..52374776)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (53111549..53117722)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 156 member A Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:53018839-53019418 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:53045322-53045423 Neighboring gene G protein-coupled receptor 173 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:53100667-53101168 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29651 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20852 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20853 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20854 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:53122416-53123240 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29653 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20855 Neighboring gene KANTR integral membrane protein Neighboring gene RNA, U7 small nuclear 37 pseudogene Neighboring gene actin gamma 1 pseudogene 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Differentially expressed nucleolar transforming growth factor-beta1 target (DENTT) exhibits an inhibitory role on tumorigenesis. Kandalaft LE, et al. Carcinogenesis, 2008 Jun. PMID 18381359, Free PMC Article
  2. Sex specific regulation of TSPY-Like 2 in the DNA damage response of cancer cells. Cardano M, et al. Cell Death Dis, 2023 Mar 15. PMID 36918555, Free PMC Article
  3. hCINAP negatively regulates NF-κB signaling by recruiting the phosphatase PP1 to deactivate IKK complex. Qu L, et al. J Mol Cell Biol, 2015 Dec. PMID 26089539
  4. hCINAP serves a critical role in hypoxia‑induced cardiomyocyte apoptosis via modulating lactate production and mitochondrial‑mediated apoptosis signaling. Xie H, et al. Mol Med Rep, 2021 Feb. PMID 33300073, Free PMC Article
  5. Identification of differentially expressed nucleolar TGF-beta1 target (DENTT) in human lung cancer cells that is a new member of the TSPY/SET/NAP-1 superfamily. Ozbun LL, et al. Genomics, 2001 Apr 15. PMID 11318608

See all (66) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TSPYL1 as a Critical Regulator of TGFbeta Signaling through Repression of TGFBR1 and TSPYL2.
    Title: TSPYL1 as a Critical Regulator of TGFβ Signaling through Repression of TGFBR1 and TSPYL2.
  2. CRL2[APPBP2]-mediated TSPYL2 degradation counteracts human mesenchymal stem cell senescence.
    Title: CRL2(APPBP2)-mediated TSPYL2 degradation counteracts human mesenchymal stem cell senescence.
  3. A tumor-suppressing role of TSPYL2 in thyroid cancer: Through interacting with SIRT1 and repressing SIRT1/AKT pathway.
    Title: A tumor-suppressing role of TSPYL2 in thyroid cancer: Through interacting with SIRT1 and repressing SIRT1/AKT pathway.
  4. Sex specific regulation of TSPY-Like 2 in the DNA damage response of cancer cells.
    Title: Sex specific regulation of TSPY-Like 2 in the DNA damage response of cancer cells.
  5. TSPYL2 reduced gefitinib resistance and DNA damage repair via suppressing SIRT1-mediated FOXO3 deacetylation.
    Title: TSPYL2 reduced gefitinib resistance and DNA damage repair via suppressing SIRT1-mediated FOXO3 deacetylation.
  6. hCINAP serves a critical role in hypoxiainduced cardiomyocyte apoptosis via modulating lactate production and mitochondrialmediated apoptosis signaling.
    Title: hCINAP serves a critical role in hypoxia‑induced cardiomyocyte apoptosis via modulating lactate production and mitochondrial‑mediated apoptosis signaling.
  7. Here we identify the nucleosome assembly protein TSPY-Like 2 (TSPYL2, also known as TSPX, DENTT, and CDA1) as a novel regulator of SIRT1 and p300 function. We demonstrate that, upon DNA damage, TSPYL2 inhibits SIRT1, disrupting its association with target proteins, and promotes p300 acetylation and activation, finally stimulating p53 acetylation and p53-dependent cell death.
    Title: TSPYL2 is a novel regulator of SIRT1 and p300 activity in response to DNA damage.
  8. Genome-wide polysome profiling shows that hCINAP selectively modulates cancer-associated translatome to promote malignancy.
    Title: The ATPase hCINAP regulates 18S rRNA processing and is essential for embryogenesis and tumour growth.
  9. Aortic CDA1 expression was downregulated approximately 70% within biopsies from human abdominal aortic aneurysms.
    Title: Diabetes Reduces Severity of Aortic Aneurysms Depending on the Presence of Cell Division Autoantigen 1 (CDA1).
  10. TSPY and TSPX exert opposing effects on the transactivation functions of AR and AR-Vs important for various physiological and disease processes sensitive to male sex hormone actions, thereby not only affecting the pathogenesis of male-specific prostate cancer but also likely contributing to sex differences in the health and diseases of man.
    Title: The Y-located proto-oncogene TSPY exacerbates and its X-homologue TSPX inhibits transactivation functions of androgen receptor and its constitutively active variants.
Submit: New GeneRIF Correction See all GeneRIFs (24)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables rDNA binding NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of DNA replication IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of cell cycle NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of cell growth IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nucleosome assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of signal transduction NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
testis-specific Y-encoded-like protein 2
Names
CASK-interacting nucleosome assembly protein
CTCL tumor antigen se20-4
CTCL-associated antigen se20-4
TSPY-like protein 2
cell division autoantigen 1
cutaneous T-cell lymphoma-associated antigen se20-4
cutaneous T-cell lymphoma-associated tumor antigen se20-4
differentially expressed nucleolar TGF-beta1 target
differentially-expressed nucleolar TGF-beta1 target protein
nuclear protein of 79 kDa
testis-specific protein Y encoded-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013267.1 RefSeqGene

    Range
    5008..11181
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_022117.4 → NP_071400.1  testis-specific Y-encoded-like protein 2

    See identical proteins and their annotated locations for NP_071400.1

    Status: REVIEWED

    Source sequence(s)
    BC024270, DA076199
    Consensus CDS
    CCDS14350.1
    UniProtKB/Swiss-Prot
    O94799, Q96DG7, Q9BZW6, Q9H2G4
    UniProtKB/TrEMBL
    A8K8U7
    Related
    ENSP00000364591.4, ENST00000375442.8
    Conserved Domains (2) summary
    pfam06957
    Location:543 → 604
    COPI_C; Coatomer (COPI) alpha subunit C-terminus
    cl08298
    Location:227 → 396
    NAP; Nucleosome assembly protein (NAP)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    53082367..53088540
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029727.2 → XP_016885216.1  testis-specific Y-encoded-like protein 2 isoform X2

    UniProtKB/TrEMBL
    A8K8U7

  2. XM_017029726.2 → XP_016885215.1  testis-specific Y-encoded-like protein 2 isoform X1

    UniProtKB/TrEMBL
    A8K8U7
    Conserved Domains (2) summary
    NF000535
    Location:486 → 660
    MSCRAMM_SdrC; MSCRAMM family adhesin SdrC
    cl08298
    Location:227 → 440
    NAP; Nucleosome assembly protein (NAP)

  3. XM_006724592.5 → XP_006724655.1  testis-specific Y-encoded-like protein 2 isoform X3

    UniProtKB/TrEMBL
    A8K8U7
    Conserved Domains (2) summary
    pfam06957
    Location:543 → 604
    COPI_C; Coatomer (COPI) alpha subunit C-terminus
    cl08298
    Location:227 → 396
    NAP; Nucleosome assembly protein (NAP)

  4. XM_047442353.1 → XP_047298309.1  testis-specific Y-encoded-like protein 2 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    52368603..52374776
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054327567.1 → XP_054183542.1  testis-specific Y-encoded-like protein 2 isoform X2

  2. XM_054327566.1 → XP_054183541.1  testis-specific Y-encoded-like protein 2 isoform X1

  3. XM_054327568.1 → XP_054183543.1  testis-specific Y-encoded-like protein 2 isoform X3

  4. XM_054327569.1 → XP_054183544.1  testis-specific Y-encoded-like protein 2 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H2G4.1 GenPept UniProtKB/Swiss-Prot:Q9H2G4

Gene LinkOut

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