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MYO1G myosin IG [ Homo sapiens (human) ]

Gene ID: 64005, updated on 2-Nov-2024

Summary

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Official Symbol
MYO1Gprovided by HGNC
Official Full Name
myosin IGprovided by HGNC
Primary source
HGNC:HGNC:13880
See related
Ensembl:ENSG00000136286 MIM:600642; AllianceGenome:HGNC:13880
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HA2; MHAG; HLA-HA2
Summary
MYO1G is a plasma membrane-associated class I myosin (see MIM 601478) that is abundant in T and B lymphocytes and mast cells (Pierce et al., 2001 [PubMed 11544309]; Patino-Lopez et al., 2010 [PubMed 20071333]).[supplied by OMIM, Jun 2010]
Expression
Biased expression in bone marrow (RPKM 19.0), spleen (RPKM 14.5) and 9 other tissues See more
Orthologs
mouse all
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Genomic context

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See MYO1G in Genome Data Viewer
Location:
7p13
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (44962662..44979015, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (45123008..45139360, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (45002261..45018614, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375262 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44951201-44951702 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44951703-44952202 Neighboring gene mitochondrial ribosomal protein S23 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44995675-44996176 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:45001789-45002289 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25958 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18159 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18160 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25960 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25959 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25961 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:45024687-45024867 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:45025394-45026140 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:45026141-45026888 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:45030540-45031094 Neighboring gene uncharacterized LOC102723334 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25966 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25963 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25964 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25965 Neighboring gene small nucleolar RNA host gene 15 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18161 Neighboring gene small nucleolar RNA, H/ACA box 9 Neighboring gene CCM2 scaffold protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of a graft versus host disease-associated human minor histocompatibility antigen. den Haan JM, et al. Science, 1995 Jun 9. PMID 7539551
  2. Detection of Myosin 1g Overexpression in Pediatric Leukemia by Novel Monoclonal Antibodies. Rodríguez-Téllez RI, et al. Int J Mol Sci, 2022 Apr 1. PMID 35409272, Free PMC Article
  3. The HA-2 minor histocompatibility antigen is derived from a diallelic gene encoding a novel human class I myosin protein. Pierce RA, et al. J Immunol, 2001 Sep 15. PMID 11544309
  4. Myosin 1G is an abundant class I myosin in lymphocytes whose localization at the plasma membrane depends on its ancient divergent pleckstrin homology (PH) domain (Myo1PH). Patino-Lopez G, et al. J Biol Chem, 2010 Mar 19. PMID 20071333, Free PMC Article
  5. Mismatch for the minor histocompatibility antigen HA-2 and GVHD occurrence in HLA-A*0201-positive Tunisian recipients of HSCs. Sellami MH, et al. Immunol Invest, 2010. PMID 20653428

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Activation of MYO1G by lncRNA MNX1-AS1 Drives the Progression in Lung Cancer.
    Title: Activation of MYO1G by lncRNA MNX1-AS1 Drives the Progression in Lung Cancer.
  2. Detection of Myosin 1g Overexpression in Pediatric Leukemia by Novel Monoclonal Antibodies.
    Title: Detection of Myosin 1g Overexpression in Pediatric Leukemia by Novel Monoclonal Antibodies.
  3. Maternal-smoking sensitive CpG sites in newborns were significantly associated with rs61087368 SNP located proximal to MYO1G.
    Title: Genetic contribution to variation in DNA methylation at maternal smoking-sensitive loci in exposed neonates.
  4. the information on allele and genotype frequencies of HA-1 and HA-2 in a Taiwanese population
    Title: Minor histocompatibility antigen HA-1 and HA-2 polymorphisms in Taiwan: frequency and application in hematopoietic stem cell transplantation.
  5. gene polymorphism does not have any significant effect on the occurrence of GVHD in Tunisia
    Title: Mismatch for the minor histocompatibility antigen HA-2 and GVHD occurrence in HLA-A*0201-positive Tunisian recipients of HSCs.
  6. Observational study of gene-disease association. (HuGE Navigator)
    Title: Degree of predicted minor histocompatibility antigen mismatch correlates with poorer clinical outcomes in nonmyeloablative allogeneic hematopoietic cell transplantation.
  7. Myosin 1G is an abundant class I myosin in lymphocytes whose localization at the plasma membrane depends on its ancient divergent pleckstrin homology (PH) domain
    Title: Myosin 1G is an abundant class I myosin in lymphocytes whose localization at the plasma membrane depends on its ancient divergent pleckstrin homology (PH) domain (Myo1PH).
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of myosin IG (MYO1G) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC142104

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphatidylinositol-3,4-bisphosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in Fc-gamma receptor signaling pathway involved in phagocytosis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in T cell meandering migration IEA
Inferred from Electronic Annotation
more info
  
involved_in T cell mediated immunity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in T cell migration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell gliding IEA
Inferred from Electronic Annotation
more info
  
involved_in cell-substrate adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment of localization in cell IEA
Inferred from Electronic Annotation
more info
  
involved_in exocytosis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular exosome HDA PubMed 
located_in filopodium IEA
Inferred from Electronic Annotation
more info
  
located_in lamellipodium IEA
Inferred from Electronic Annotation
more info
  
located_in leading edge membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane HDA PubMed 
is_active_in microvillus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in phagocytic cup ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
unconventional myosin-Ig
Names
minor histocompatibility antigen HA-2
myosin-Ig

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033054.3 → NP_149043.2  unconventional myosin-Ig

    See identical proteins and their annotated locations for NP_149043.2

    Status: VALIDATED

    Source sequence(s)
    AA651942, AC004847, BC117241
    Consensus CDS
    CCDS34629.1
    UniProtKB/Swiss-Prot
    B0I1T2, Q8TEI9, Q8TES2, Q96BE2, Q96RI5, Q96RI6
    UniProtKB/TrEMBL
    A0A3B3IU30
    Related
    ENSP00000258787.7, ENST00000258787.12
    Conserved Domains (3) summary
    smart00242
    Location:4 → 706
    MYSc; Myosin. Large ATPases
    cd01378
    Location:23 → 694
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:815 → 980
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    44962662..44979015 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_007060129.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    45123008..45139360 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_008487727.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B0I1T2.2 GenPept UniProtKB/Swiss-Prot:B0I1T2

Gene LinkOut

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