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TMEM95 transmembrane protein 95 [ Bos taurus (domestic cattle) ]

Gene ID: 614631, updated on 17-Aug-2024

Summary

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Official Symbol
TMEM95provided by VGNC
Official Full Name
transmembrane protein 95provided by VGNC
Primary source
VGNC:VGNC:106985
See related
BGD:BT24022; Ensembl:ENSBTAG00000052395
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See TMEM95 in Genome Data Viewer
Location:
chromosome: 19
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 19 NC_037346.1 (27054969..27059048)

Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene neuralized E3 ubiquitin protein ligase 4 Neighboring gene uncharacterized LOC132343038 Neighboring gene ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 Neighboring gene potassium channel tetramerization domain containing 11 Neighboring gene tyrosine kinase non receptor 1 Neighboring gene phospholipid scramblase 3 Neighboring gene transmembrane protein 256

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Subfertility in bulls carrying a nonsense mutation in transmembrane protein 95 is due to failure to interact with the oocyte vestments. Fernandez-Fuertes B, et al. Biol Reprod, 2017 Jul 1. PMID 28859280
  2. Identification of novel alternative splicing transcript and expression analysis of bovine TMEM95 gene. Zhang S, et al. Gene, 2016 Jan 10. PMID 26385321
  3. A nonsense mutation in TMEM95 encoding a nondescript transmembrane protein causes idiopathic male subfertility in cattle. Pausch H, et al. PLoS Genet, 2014 Jan. PMID 24391514, Free PMC Article
  4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A nonsense mutation of TMEM95 on bull fertility was shown to affect sperm--oocyte interactions.
    Title: Subfertility in bulls carrying a nonsense mutation in transmembrane protein 95 is due to failure to interact with the oocyte vestments.
  2. Our results demonstrate that deficiency of TMEM95 severely compromises male reproductive performance in cattle and reveal for the first time a phenotypic effect associated with genomic variation in TMEM95.
    Title: A nonsense mutation in TMEM95 encoding a nondescript transmembrane protein causes idiopathic male subfertility in cattle.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Process Evidence Code Pubs
involved_in fusion of sperm to egg plasma membrane involved in single fertilization IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in acrosomal membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in sperm plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
sperm-egg fusion protein TMEM95

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001367291.1 → NP_001354220.1  sperm-egg fusion protein TMEM95 precursor

    Status: VALIDATED

    Source sequence(s)
    NKLS02000019
    UniProtKB/Swiss-Prot
    A0A0N9GZ96, A0A3Q1LRJ2
    Related
    ENSBTAP00000062895.2, ENSBTAT00000080171.2
    Conserved Domains (1) summary
    pfam15203
    Location:17 → 167
    TMEM95; TMEM95 family

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    27054969..27059048
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_010815969.4 → XP_010814271.2  sperm-egg fusion protein TMEM95 isoform X1

    Conserved Domains (1) summary
    pfam15203
    Location:17 → 153
    TMEM95; TMEM95 family

  2. XM_059878225.1 → XP_059734208.1  sperm-egg fusion protein TMEM95 isoform X2

  3. XM_010815970.4 → XP_010814272.2  sperm-egg fusion protein TMEM95 isoform X3

    Conserved Domains (1) summary
    pfam15203
    Location:17 → 110
    TMEM95; TMEM95 family

  4. XM_002695800.6 → XP_002695846.3  sperm-egg fusion protein TMEM95 isoform X4

    Conserved Domains (1) summary
    pfam15203
    Location:17 → 210
    TMEM95; TMEM95 family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A3Q1LRJ2.2 GenPept UniProtKB/Swiss-Prot:A0A3Q1LRJ2

Gene LinkOut

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