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BCAN brevican [ Canis lupus familiaris (dog) ]

Gene ID: 612102, updated on 17-Aug-2024

Summary

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Official Symbol
BCANprovided by VGNC
Official Full Name
brevicanprovided by VGNC
Primary source
VGNC:VGNC:38395
See related
Ensembl:ENSCAFG00845008548
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See BCAN in Genome Data Viewer
Location:
chromosome: 7
Exon count:
14
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 7 NC_051811.1 (41176717..41193313, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 7 NC_006589.4 (40800863..40817472, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 7 NC_049228.1 (41295291..41311883, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 7 NC_049267.1 (40958653..40975224, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 7 NC_049748.1 (41011623..41028215, complement)

Chromosome 7 - NC_051811.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119872564 Neighboring gene cellular retinoic acid binding protein 2 Neighboring gene nestin Neighboring gene hyaluronan and proteoglycan link protein 2 Neighboring gene G-patch domain containing 4 Neighboring gene NAD(P)HX epimerase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A canine BCAN microdeletion associated with episodic falling syndrome. Gill JL, et al. Neurobiol Dis, 2012 Jan. PMID 21821125, Free PMC Article
  2. Parallel mapping and simultaneous sequencing reveals deletions in BCAN and FAM83H associated with discrete inherited disorders in a domestic dog breed. Forman OP, et al. PLoS Genet, 2012 Jan. PMID 22253609, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables hyaluronic acid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
brevican core protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001284437.1 → NP_001271366.1  brevican core protein precursor

    See identical proteins and their annotated locations for NP_001271366.1

    Status: PROVISIONAL

    Source sequence(s)
    JN968467
    UniProtKB/TrEMBL
    A0A8C0QVK2, A0A8P0NHY0, H6VX53
    Conserved Domains (8) summary
    cd00033
    Location:814 → 871
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd03517
    Location:157 → 251
    Link_domain_CSPGs_modules_1_3; Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: ...
    cd03520
    Location:258 → 353
    Link_domain_CSPGs_modules_2_4; Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The ...
    pfam00008
    Location:649 → 678
    EGF; EGF-like domain
    cl02432
    Location:687 → 810
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    cl11960
    Location:49 → 158
    Ig; Immunoglobulin domain
    cl25836
    Location:504 → 621
    Retinal; Retinal protein
    cl26386
    Location:355 → 541
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051811.1 Reference ROS_Cfam_1.0

    Range
    41176717..41193313 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038670555.1 → XP_038526483.1  brevican core protein isoform X1

    UniProtKB/TrEMBL
    A0A8P0NHY0
    Conserved Domains (9) summary
    cd00033
    Location:840 → 897
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    PRK07764
    Location:355 → 541
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd03517
    Location:157 → 251
    Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: versican, neurocan, and brevican. ...
    cd03520
    Location:258 → 353
    Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The link domain is a hyaluronan ...
    pfam00008
    Location:649 → 678
    EGF; EGF-like domain
    cd00096
    Location:39 → 42
    Ig; Ig strand A [structural motif]
    NF033913
    Location:481 → 646
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
    cl02432
    Location:687 → 836
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    cl11960
    Location:39 → 159
    Ig; Immunoglobulin domain

  2. XM_038670556.1 → XP_038526484.1  brevican core protein isoform X2

    UniProtKB/TrEMBL
    A0A8P0NHY0
    Conserved Domains (9) summary
    cd00033
    Location:840 → 897
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    PRK07764
    Location:355 → 541
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd03517
    Location:157 → 251
    Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: versican, neurocan, and brevican. ...
    cd03520
    Location:258 → 353
    Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The link domain is a hyaluronan ...
    pfam00008
    Location:649 → 678
    EGF; EGF-like domain
    cd00096
    Location:39 → 42
    Ig; Ig strand A [structural motif]
    NF033913
    Location:481 → 646
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
    cl02432
    Location:687 → 836
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    cl11960
    Location:39 → 159
    Ig; Immunoglobulin domain

  3. XM_038670557.1 → XP_038526485.1  brevican core protein isoform X3

    UniProtKB/TrEMBL
    A0A8I3N8Z0, A0A8P0NHY0
    Related
    ENSCAFP00845011659.1, ENSCAFT00845015032.1
    Conserved Domains (9) summary
    cd00033
    Location:814 → 871
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    PRK07764
    Location:355 → 541
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd03517
    Location:157 → 251
    Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: versican, neurocan, and brevican. ...
    cd03520
    Location:258 → 353
    Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The link domain is a hyaluronan ...
    pfam00008
    Location:649 → 678
    EGF; EGF-like domain
    cd00096
    Location:39 → 42
    Ig; Ig strand A [structural motif]
    NF033913
    Location:481 → 646
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
    cl02432
    Location:687 → 810
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    cl11960
    Location:39 → 159
    Ig; Immunoglobulin domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049267.1 Alternate UMICH_Zoey_3.1

    Range
    40958653..40975224 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049748.1 Alternate UNSW_CanFamBas_1.0

    Range
    41011623..41028215 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049228.1 Alternate UU_Cfam_GSD_1.0

    Range
    41295291..41311883 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006589.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    40800863..40817472 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
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