U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

RASGRP2 RAS guanyl releasing protein 2 [ Canis lupus familiaris (dog) ]

Gene ID: 612101, updated on 17-Aug-2024

Summary

Go to the top of the page Help
Official Symbol
RASGRP2provided by VGNC
Official Full Name
RAS guanyl releasing protein 2provided by VGNC
Primary source
VGNC:VGNC:45372
See related
Ensembl:ENSCAFG00845029413
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See RASGRP2 in Genome Data Viewer
Location:
chromosome: 18
Exon count:
20
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 18 NC_051822.1 (53453534..53467923)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 18 NC_006600.4 (51019635..51034051)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 18 NC_049239.1 (52918511..52932911)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 18 NC_049278.1 (52548448..52562832)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 18 NC_049759.1 (52134369..52148760)

Chromosome 18 - NC_051822.1Genomic Context describing neighboring genes Neighboring gene splicing factor 1 Neighboring gene glycogen phosphorylase, muscle associated Neighboring gene neurexin 2 Neighboring gene uncharacterized LOC102151513

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
RAS guanyl-releasing protein 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051822.1 Reference ROS_Cfam_1.0

    Range
    53453534..53467923
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038425142.1 → XP_038281070.1  RAS guanyl-releasing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0MBT8
    Conserved Domains (4) summary
    smart00147
    Location:151 → 388
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:7 → 122
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00051
    Location:431 → 482
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd20861
    Location:497 → 552
    C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins

  2. XM_038425147.1 → XP_038281075.1  RAS guanyl-releasing protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0KMB4, A0A8C0MBT8, A0A8I3Q8A5, A0A8P0NG65
    Conserved Domains (4) summary
    smart00147
    Location:150 → 387
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:7 → 121
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00051
    Location:430 → 481
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd20861
    Location:496 → 551
    C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins

  3. XM_038425144.1 → XP_038281072.1  RAS guanyl-releasing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0MBT8
    Conserved Domains (4) summary
    smart00147
    Location:151 → 388
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:7 → 122
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00051
    Location:431 → 482
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd20861
    Location:497 → 552
    C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins

  4. XM_038425143.1 → XP_038281071.1  RAS guanyl-releasing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0MBT8
    Conserved Domains (4) summary
    smart00147
    Location:151 → 388
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:7 → 122
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00051
    Location:431 → 482
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd20861
    Location:497 → 552
    C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins

  5. XM_038425145.1 → XP_038281073.1  RAS guanyl-releasing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0MBT8
    Conserved Domains (4) summary
    smart00147
    Location:151 → 388
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:7 → 122
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00051
    Location:431 → 482
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd20861
    Location:497 → 552
    C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins

  6. XM_038425148.1 → XP_038281076.1  RAS guanyl-releasing protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0KMB4, A0A8C0MBT8, A0A8I3Q8A5, A0A8P0NG65
    Related
    ENSCAFP00845040909.1, ENSCAFT00845052160.1
    Conserved Domains (4) summary
    smart00147
    Location:150 → 387
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:7 → 121
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00051
    Location:430 → 481
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd20861
    Location:496 → 551
    C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins

  7. XM_038425146.1 → XP_038281074.1  RAS guanyl-releasing protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0KMB4, A0A8C0MBT8, A0A8I3Q8A5, A0A8P0NG65
    Conserved Domains (4) summary
    smart00147
    Location:150 → 387
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:7 → 121
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00051
    Location:430 → 481
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd20861
    Location:496 → 551
    C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins

  8. XM_038425149.1 → XP_038281077.1  RAS guanyl-releasing protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0MBT8
    Conserved Domains (4) summary
    smart00147
    Location:133 → 370
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00051
    Location:413 → 464
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd20861
    Location:479 → 534
    C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins
    cl02520
    Location:11 → 104
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049278.1 Alternate UMICH_Zoey_3.1

    Range
    52548448..52562832
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038501393.1 → XP_038357321.1  RAS guanyl-releasing protein 2 isoform X1

    Conserved Domains (4) summary
    smart00147
    Location:151 → 388
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:7 → 122
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00051
    Location:431 → 482
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd20861
    Location:497 → 552
    C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins

  2. XM_038501398.1 → XP_038357326.1  RAS guanyl-releasing protein 2 isoform X2

    Conserved Domains (4) summary
    smart00147
    Location:150 → 387
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:7 → 121
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00051
    Location:430 → 481
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd20861
    Location:496 → 551
    C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins

  3. XM_038501395.1 → XP_038357323.1  RAS guanyl-releasing protein 2 isoform X1

    Conserved Domains (4) summary
    smart00147
    Location:151 → 388
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:7 → 122
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00051
    Location:431 → 482
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd20861
    Location:497 → 552
    C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins

  4. XM_038501394.1 → XP_038357322.1  RAS guanyl-releasing protein 2 isoform X1

    Conserved Domains (4) summary
    smart00147
    Location:151 → 388
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:7 → 122
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00051
    Location:431 → 482
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd20861
    Location:497 → 552
    C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins

  5. XM_038501396.1 → XP_038357324.1  RAS guanyl-releasing protein 2 isoform X1

    Conserved Domains (4) summary
    smart00147
    Location:151 → 388
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:7 → 122
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00051
    Location:431 → 482
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd20861
    Location:497 → 552
    C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins

  6. XM_038501399.1 → XP_038357327.1  RAS guanyl-releasing protein 2 isoform X2

    Conserved Domains (4) summary
    smart00147
    Location:150 → 387
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:7 → 121
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00051
    Location:430 → 481
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd20861
    Location:496 → 551
    C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins

  7. XM_038501397.1 → XP_038357325.1  RAS guanyl-releasing protein 2 isoform X2

    Conserved Domains (4) summary
    smart00147
    Location:150 → 387
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:7 → 121
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00051
    Location:430 → 481
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd20861
    Location:496 → 551
    C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins

  8. XM_038501400.1 → XP_038357328.1  RAS guanyl-releasing protein 2 isoform X3

    Conserved Domains (4) summary
    smart00147
    Location:133 → 370
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00051
    Location:413 → 464
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd20861
    Location:479 → 534
    C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins
    cl02520
    Location:11 → 104
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049759.1 Alternate UNSW_CanFamBas_1.0

    Range
    52134369..52148760
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038628212.1 → XP_038484140.1  RAS guanyl-releasing protein 2 isoform X1

    Conserved Domains (4) summary
    smart00147
    Location:151 → 388
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:7 → 122
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00051
    Location:431 → 482
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd20861
    Location:497 → 552
    C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins

  2. XM_038628217.1 → XP_038484145.1  RAS guanyl-releasing protein 2 isoform X2

    Conserved Domains (4) summary
    smart00147
    Location:150 → 387
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:7 → 121
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00051
    Location:430 → 481
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd20861
    Location:496 → 551
    C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins

  3. XM_038628214.1 → XP_038484142.1  RAS guanyl-releasing protein 2 isoform X1

    Conserved Domains (4) summary
    smart00147
    Location:151 → 388
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:7 → 122
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00051
    Location:431 → 482
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd20861
    Location:497 → 552
    C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins

  4. XM_038628213.1 → XP_038484141.1  RAS guanyl-releasing protein 2 isoform X1

    Conserved Domains (4) summary
    smart00147
    Location:151 → 388
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:7 → 122
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00051
    Location:431 → 482
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd20861
    Location:497 → 552
    C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins

  5. XM_038628215.1 → XP_038484143.1  RAS guanyl-releasing protein 2 isoform X1

    Conserved Domains (4) summary
    smart00147
    Location:151 → 388
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:7 → 122
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00051
    Location:431 → 482
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd20861
    Location:497 → 552
    C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins

  6. XM_038628218.1 → XP_038484146.1  RAS guanyl-releasing protein 2 isoform X2

    Conserved Domains (4) summary
    smart00147
    Location:150 → 387
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:7 → 121
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00051
    Location:430 → 481
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd20861
    Location:496 → 551
    C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins

  7. XM_038628216.1 → XP_038484144.1  RAS guanyl-releasing protein 2 isoform X2

    Conserved Domains (4) summary
    smart00147
    Location:150 → 387
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:7 → 121
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00051
    Location:430 → 481
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd20861
    Location:496 → 551
    C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins

  8. XM_038628219.1 → XP_038484147.1  RAS guanyl-releasing protein 2 isoform X3

    Conserved Domains (4) summary
    smart00147
    Location:133 → 370
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00051
    Location:413 → 464
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd20861
    Location:479 → 534
    C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins
    cl02520
    Location:11 → 104
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049239.1 Alternate UU_Cfam_GSD_1.0

    Range
    52918511..52932911
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038564078.1 → XP_038420006.1  RAS guanyl-releasing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0MBT8
    Conserved Domains (4) summary
    smart00147
    Location:151 → 388
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:7 → 122
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00051
    Location:431 → 482
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd20861
    Location:497 → 552
    C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins

  2. XM_038564083.1 → XP_038420011.1  RAS guanyl-releasing protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0KMB4, A0A8C0MBT8, A0A8I3Q8A5, A0A8P0NG65
    Conserved Domains (4) summary
    smart00147
    Location:150 → 387
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:7 → 121
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00051
    Location:430 → 481
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd20861
    Location:496 → 551
    C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins

  3. XM_038564080.1 → XP_038420008.1  RAS guanyl-releasing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0MBT8
    Conserved Domains (4) summary
    smart00147
    Location:151 → 388
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:7 → 122
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00051
    Location:431 → 482
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd20861
    Location:497 → 552
    C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins

  4. XM_038564079.1 → XP_038420007.1  RAS guanyl-releasing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0MBT8
    Conserved Domains (4) summary
    smart00147
    Location:151 → 388
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:7 → 122
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00051
    Location:431 → 482
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd20861
    Location:497 → 552
    C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins

  5. XM_038564081.1 → XP_038420009.1  RAS guanyl-releasing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0MBT8
    Conserved Domains (4) summary
    smart00147
    Location:151 → 388
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:7 → 122
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00051
    Location:431 → 482
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd20861
    Location:497 → 552
    C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins

  6. XM_038564084.1 → XP_038420012.1  RAS guanyl-releasing protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0KMB4, A0A8C0MBT8, A0A8I3Q8A5, A0A8P0NG65
    Conserved Domains (4) summary
    smart00147
    Location:150 → 387
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:7 → 121
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00051
    Location:430 → 481
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd20861
    Location:496 → 551
    C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins

  7. XM_038564082.1 → XP_038420010.1  RAS guanyl-releasing protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0KMB4, A0A8C0MBT8, A0A8I3Q8A5, A0A8P0NG65
    Conserved Domains (4) summary
    smart00147
    Location:150 → 387
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:7 → 121
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00051
    Location:430 → 481
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd20861
    Location:496 → 551
    C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins

  8. XM_038564085.1 → XP_038420013.1  RAS guanyl-releasing protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0MBT8
    Conserved Domains (4) summary
    smart00147
    Location:133 → 370
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00051
    Location:413 → 464
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd20861
    Location:479 → 534
    C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins
    cl02520
    Location:11 → 104
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006600.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    51019635..51034051
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005631518.4 → XP_005631575.1  RAS guanyl-releasing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0MBT8
    Conserved Domains (4) summary
    smart00147
    Location:151 → 388
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:7 → 122
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00051
    Location:431 → 482
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd20861
    Location:497 → 552
    C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins

  2. XM_849829.6 → XP_854922.1  RAS guanyl-releasing protein 2 isoform X2

    See identical proteins and their annotated locations for XP_854922.1

    UniProtKB/TrEMBL
    A0A8C0KMB4, A0A8C0MBT8, A0A8I3Q8A5, A0A8P0NG65
    Conserved Domains (4) summary
    smart00147
    Location:150 → 387
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:7 → 121
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00051
    Location:430 → 481
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd20861
    Location:496 → 551
    C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins

  3. XM_038454104.1 → XP_038310032.1  RAS guanyl-releasing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0MBT8
    Conserved Domains (4) summary
    smart00147
    Location:151 → 388
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:7 → 122
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00051
    Location:431 → 482
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd20861
    Location:497 → 552
    C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins

  4. XM_038454103.1 → XP_038310031.1  RAS guanyl-releasing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0MBT8
    Conserved Domains (4) summary
    smart00147
    Location:151 → 388
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:7 → 122
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00051
    Location:431 → 482
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd20861
    Location:497 → 552
    C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins

  5. XM_038454105.1 → XP_038310033.1  RAS guanyl-releasing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0MBT8
    Conserved Domains (4) summary
    smart00147
    Location:151 → 388
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:7 → 122
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00051
    Location:431 → 482
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd20861
    Location:497 → 552
    C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins

  6. XM_005631519.4 → XP_005631576.1  RAS guanyl-releasing protein 2 isoform X2

    See identical proteins and their annotated locations for XP_005631576.1

    UniProtKB/TrEMBL
    A0A8C0KMB4, A0A8C0MBT8, A0A8I3Q8A5, A0A8P0NG65
    Conserved Domains (4) summary
    smart00147
    Location:150 → 387
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:7 → 121
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00051
    Location:430 → 481
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd20861
    Location:496 → 551
    C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins

  7. XM_038454106.1 → XP_038310034.1  RAS guanyl-releasing protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0KMB4, A0A8C0MBT8, A0A8I3Q8A5, A0A8P0NG65
    Conserved Domains (4) summary
    smart00147
    Location:150 → 387
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:7 → 121
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00051
    Location:430 → 481
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd20861
    Location:496 → 551
    C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins

  8. XM_038454107.1 → XP_038310035.1  RAS guanyl-releasing protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0MBT8
    Conserved Domains (4) summary
    smart00147
    Location:133 → 370
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00051
    Location:413 → 464
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd20861
    Location:479 → 534
    C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins
    cl02520
    Location:11 → 104
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials