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MPO myeloperoxidase [ Canis lupus familiaris (dog) ]

Gene ID: 609986, updated on 17-Aug-2024

Summary

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Official Symbol
MPOprovided by VGNC
Official Full Name
myeloperoxidaseprovided by VGNC
Primary source
VGNC:VGNC:43341
See related
Ensembl:ENSCAFG00845018435
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See MPO in Genome Data Viewer
Location:
chromosome: 9
Exon count:
14
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 9 NC_051813.1 (33734267..33744696, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 9 NC_006591.4 (32164643..32175070, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 9 NC_049230.1 (32897366..32907792, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 9 NC_049269.1 (32520407..32530846, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 9 NC_049750.1 (32803860..32814324, complement)

Chromosome 9 - NC_051813.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111097404 Neighboring gene lactoperoxidase Neighboring gene uncharacterized LOC111097405 Neighboring gene TSPO associated protein 1 Neighboring gene microRNA mir-142

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Myeloperoxidase enzyme and Ferric-reducing antioxidant power concentrations in lean and obese dogs. Paulo RR, et al. Vet Res Commun, 2023 Jun. PMID 36572754
  2. S100A12 concentrations and myeloperoxidase activity in the intestinal mucosa of healthy dogs. Hanifeh M, et al. BMC Vet Res, 2015 Sep 14. PMID 26370713, Free PMC Article
  3. Anti-myeloperoxidase and anti-cathepsin G antibodies in sulphonamide hypersensitivity. Lavergne SN, et al. Clin Exp Allergy, 2008 Jan. PMID 17976219
  4. Proteome Analyses Reveal Positive Association of COL2A1, MPO, TYMS, and IGFBP5 with Canine Mammary Gland Malignancy. Wu CC, et al. Proteomics Clin Appl, 2019 Jul. PMID 30578659
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Myeloperoxidase enzyme and Ferric-reducing antioxidant power concentrations in lean and obese dogs.
    Title: Myeloperoxidase enzyme and Ferric-reducing antioxidant power concentrations in lean and obese dogs.
  2. COL2A1, MPO, TYMS, and IGFBP5 protein levels are positively associated with canine mammary tumors (CMTs) development. Data expedite further investigations to improve treatment regimens for CMT.
    Title: Proteome Analyses Reveal Positive Association of COL2A1, MPO, TYMS, and IGFBP5 with Canine Mammary Gland Malignancy.
  3. S100A12 and myeloperoxidase may play a role in the pathogenesis of canine chronic intestinal inflammation.
    Title: S100A12 concentrations and myeloperoxidase activity in the intestinal mucosa of healthy dogs.
  4. anti-MPO antibodies and anti-cathepsin G antibodies are associated with sulphonamide hypersensitivity
    Title: Anti-myeloperoxidase and anti-cathepsin G antibodies in sulphonamide hypersensitivity.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables peroxidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
myeloperoxidase
XP_022278900.1
XP_022278901.1
XP_038342008.1
XP_038342009.1
XP_038342010.1
XP_038403799.1
XP_038403801.1
XP_038403802.1
XP_038467779.1
XP_038467780.1
XP_038467781.1
XP_038533004.1
XP_038533005.1
XP_038533006.1
XP_852445.2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051813.1 Reference ROS_Cfam_1.0

    Range
    33734267..33744696 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038677076.1 → XP_038533004.1  myeloperoxidase

    UniProtKB/TrEMBL
    A0A8I3P6N3, A0A8P0PFH6
    Related
    ENSCAFP00845025727.1, ENSCAFT00845032874.1
    Conserved Domains (1) summary
    cd09824
    Location:288 → 701
    myeloperoxidase_like; Myeloperoxidases, eosinophil peroxidases, and lactoperoxidases

  2. XM_038677077.1 → XP_038533005.1  myeloperoxidase

    UniProtKB/TrEMBL
    A0A8I3P6N3, A0A8P0PFH6
    Conserved Domains (1) summary
    cd09824
    Location:288 → 701
    myeloperoxidase_like; Myeloperoxidases, eosinophil peroxidases, and lactoperoxidases

  3. XM_038677078.1 → XP_038533006.1  myeloperoxidase

    UniProtKB/TrEMBL
    A0A8I3P6N3, A0A8P0PFH6
    Related
    ENSCAFP00845025553.1, ENSCAFT00845032667.1
    Conserved Domains (1) summary
    cd09824
    Location:288 → 701
    myeloperoxidase_like; Myeloperoxidases, eosinophil peroxidases, and lactoperoxidases

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049269.1 Alternate UMICH_Zoey_3.1

    Range
    32520407..32530846 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038486080.1 → XP_038342008.1  myeloperoxidase

    Conserved Domains (1) summary
    cd09824
    Location:288 → 701
    myeloperoxidase_like; Myeloperoxidases, eosinophil peroxidases, and lactoperoxidases

  2. XM_038486081.1 → XP_038342009.1  myeloperoxidase

    Conserved Domains (1) summary
    cd09824
    Location:288 → 701
    myeloperoxidase_like; Myeloperoxidases, eosinophil peroxidases, and lactoperoxidases

  3. XM_038486082.1 → XP_038342010.1  myeloperoxidase

    Conserved Domains (1) summary
    cd09824
    Location:288 → 701
    myeloperoxidase_like; Myeloperoxidases, eosinophil peroxidases, and lactoperoxidases

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049750.1 Alternate UNSW_CanFamBas_1.0

    Range
    32803860..32814324 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038611851.1 → XP_038467779.1  myeloperoxidase

    Conserved Domains (1) summary
    cd09824
    Location:288 → 701
    myeloperoxidase_like; Myeloperoxidases, eosinophil peroxidases, and lactoperoxidases

  2. XM_038611852.1 → XP_038467780.1  myeloperoxidase

    Conserved Domains (1) summary
    cd09824
    Location:288 → 701
    myeloperoxidase_like; Myeloperoxidases, eosinophil peroxidases, and lactoperoxidases

  3. XM_038611853.1 → XP_038467781.1  myeloperoxidase

    Conserved Domains (1) summary
    cd09824
    Location:288 → 701
    myeloperoxidase_like; Myeloperoxidases, eosinophil peroxidases, and lactoperoxidases

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049230.1 Alternate UU_Cfam_GSD_1.0

    Range
    32897366..32907792 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038547871.1 → XP_038403799.1  myeloperoxidase

    UniProtKB/TrEMBL
    A0A8I3P6N3, A0A8P0PFH6
    Conserved Domains (1) summary
    cd09824
    Location:288 → 701
    myeloperoxidase_like; Myeloperoxidases, eosinophil peroxidases, and lactoperoxidases

  2. XM_038547873.1 → XP_038403801.1  myeloperoxidase

    UniProtKB/TrEMBL
    A0A8I3P6N3, A0A8P0PFH6
    Conserved Domains (1) summary
    cd09824
    Location:288 → 701
    myeloperoxidase_like; Myeloperoxidases, eosinophil peroxidases, and lactoperoxidases

  3. XM_038547874.1 → XP_038403802.1  myeloperoxidase

    UniProtKB/TrEMBL
    A0A8I3P6N3, A0A8P0PFH6
    Conserved Domains (1) summary
    cd09824
    Location:288 → 701
    myeloperoxidase_like; Myeloperoxidases, eosinophil peroxidases, and lactoperoxidases

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006591.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    32164643..32175070 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_847352.5 → XP_852445.2  myeloperoxidase

    UniProtKB/TrEMBL
    A0A8I3P6N3, A0A8P0PFH6
    Conserved Domains (1) summary
    cd09824
    Location:288 → 701
    myeloperoxidase_like; Myeloperoxidases, eosinophil peroxidases, and lactoperoxidases

  2. XM_022423192.2 → XP_022278900.1  myeloperoxidase

    UniProtKB/TrEMBL
    A0A8I3P6N3, A0A8P0PFH6
    Conserved Domains (1) summary
    cd09824
    Location:288 → 701
    myeloperoxidase_like; Myeloperoxidases, eosinophil peroxidases, and lactoperoxidases

  3. XM_022423193.2 → XP_022278901.1  myeloperoxidase

    UniProtKB/TrEMBL
    A0A8I3P6N3, A0A8P0PFH6
    Conserved Domains (1) summary
    cd09824
    Location:288 → 701
    myeloperoxidase_like; Myeloperoxidases, eosinophil peroxidases, and lactoperoxidases
Nucleotide Protein
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