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ARHGEF10 Rho guanine nucleotide exchange factor 10 [ Canis lupus familiaris (dog) ]

Gene ID: 609511, updated on 17-Aug-2024

Summary

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Official Symbol
ARHGEF10provided by VGNC
Official Full Name
Rho guanine nucleotide exchange factor 10provided by VGNC
Primary source
VGNC:VGNC:38072
See related
Ensembl:ENSCAFG00845025529
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See ARHGEF10 in Genome Data Viewer
Location:
chromosome: 16
Exon count:
30
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 16 NC_051820.1 (61881132..61970321, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 16 NC_006598.4 (49689515..49778687)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 16 NC_049237.1 (60173735..60263094, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 16 NC_049276.1 (54329445..54418473)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 16 NC_049757.1 (59789595..59878802, complement)

Chromosome 16 - NC_051820.1Genomic Context describing neighboring genes Neighboring gene myomesin 2 Neighboring gene kelch repeat and BTB domain containing 11 Neighboring gene uncharacterized LOC119869520 Neighboring gene uncharacterized LOC119869521

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An ARHGEF10 deletion is highly associated with a juvenile-onset inherited polyneuropathy in Leonberger and Saint Bernard dogs. Ekenstedt KJ, et al. PLoS Genet, 2014 Oct. PMID 25275565, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. An ARHGEF10 deletion is highly associated with a juvenile-onset inherited polyneuropathy in Leonberger and Saint Bernard dogs.
    Title: An ARHGEF10 deletion is highly associated with a juvenile-onset inherited polyneuropathy in Leonberger and Saint Bernard dogs.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in mitotic spindle assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of stress fiber assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in centrosome IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
rho guanine nucleotide exchange factor 10; LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 10

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051820.1 Reference ROS_Cfam_1.0

    Range
    61881132..61970321 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038690380.1 → XP_038546308.1  rho guanine nucleotide exchange factor 10 isoform X3

    UniProtKB/TrEMBL
    A0A8I3S5G3
    Related
    ENSCAFP00845035337.1, ENSCAFT00845045076.1
    Conserved Domains (3) summary
    cd00160
    Location:355 → 539
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    pfam19056
    Location:819 → 1289
    WD40_2; WD40 repeated domain
    pfam19057
    Location:562 → 711
    PH_19; PH domain

  2. XM_038690379.1 → XP_038546307.1  rho guanine nucleotide exchange factor 10 isoform X2

    UniProtKB/TrEMBL
    A0A8I3S5G3
    Conserved Domains (3) summary
    cd00160
    Location:394 → 577
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    pfam19056
    Location:857 → 1327
    WD40_2; WD40 repeated domain
    pfam19057
    Location:600 → 749
    PH_19; PH domain

  3. XM_038690377.1 → XP_038546305.1  rho guanine nucleotide exchange factor 10 isoform X1

    UniProtKB/TrEMBL
    A0A8I3S5G3
    Related
    ENSCAFP00845035770.1, ENSCAFT00845045597.1
    Conserved Domains (3) summary
    cd00160
    Location:394 → 578
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    pfam19056
    Location:858 → 1328
    WD40_2; WD40 repeated domain
    pfam19057
    Location:601 → 750
    PH_19; PH domain

  4. XM_038690378.1 → XP_038546306.1  rho guanine nucleotide exchange factor 10 isoform X1

    UniProtKB/TrEMBL
    A0A8I3S5G3
    Conserved Domains (3) summary
    cd00160
    Location:394 → 578
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    pfam19056
    Location:858 → 1328
    WD40_2; WD40 repeated domain
    pfam19057
    Location:601 → 750
    PH_19; PH domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049276.1 Alternate UMICH_Zoey_3.1

    Range
    54329445..54418473
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038498040.1 → XP_038353968.1  LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 10 isoform X1

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049757.1 Alternate UNSW_CanFamBas_1.0

    Range
    59789595..59878802 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038624593.1 → XP_038480521.1  rho guanine nucleotide exchange factor 10 isoform X3

  2. XM_038624592.1 → XP_038480520.1  rho guanine nucleotide exchange factor 10 isoform X2

  3. XM_038624590.1 → XP_038480518.1  rho guanine nucleotide exchange factor 10 isoform X1

  4. XM_038624591.1 → XP_038480519.1  rho guanine nucleotide exchange factor 10 isoform X1

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049237.1 Alternate UU_Cfam_GSD_1.0

    Range
    60173735..60263094 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038560553.1 → XP_038416481.1  rho guanine nucleotide exchange factor 10 isoform X3

    UniProtKB/TrEMBL
    A0A8I3S5G3

  2. XM_038560552.1 → XP_038416480.1  rho guanine nucleotide exchange factor 10 isoform X2

    UniProtKB/TrEMBL
    A0A8I3S5G3

  3. XM_038560549.1 → XP_038416477.1  rho guanine nucleotide exchange factor 10 isoform X1

    UniProtKB/TrEMBL
    A0A8I3S5G3

  4. XM_038560551.1 → XP_038416479.1  rho guanine nucleotide exchange factor 10 isoform X1

    UniProtKB/TrEMBL
    A0A8I3S5G3

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006598.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    49689515..49778687
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038452317.1 → XP_038308245.1  rho guanine nucleotide exchange factor 10 isoform X1

    UniProtKB/TrEMBL
    A0A8I3S5G3, A0A8P0TPS0
    Conserved Domains (3) summary
    cd00160
    Location:394 → 578
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    pfam19056
    Location:858 → 1328
    WD40_2; WD40 repeated domain
    pfam19057
    Location:601 → 750
    PH_19; PH domain

  2. XM_038452319.1 → XP_038308247.1  rho guanine nucleotide exchange factor 10 isoform X2

    UniProtKB/TrEMBL
    A0A8I3S5G3
    Conserved Domains (3) summary
    cd00160
    Location:394 → 577
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    pfam19056
    Location:857 → 1327
    WD40_2; WD40 repeated domain
    pfam19057
    Location:600 → 749
    PH_19; PH domain

  3. XM_038452321.1 → XP_038308249.1  rho guanine nucleotide exchange factor 10 isoform X3

    UniProtKB/TrEMBL
    A0A8I3S5G3, A0A8P0TJQ1
    Conserved Domains (3) summary
    cd00160
    Location:355 → 539
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    pfam19056
    Location:819 → 1289
    WD40_2; WD40 repeated domain
    pfam19057
    Location:562 → 711
    PH_19; PH domain

  4. XM_038452318.1 → XP_038308246.1  rho guanine nucleotide exchange factor 10 isoform X1

    UniProtKB/TrEMBL
    A0A8I3S5G3, A0A8P0TPS0
    Conserved Domains (3) summary
    cd00160
    Location:394 → 578
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    pfam19056
    Location:858 → 1328
    WD40_2; WD40 repeated domain
    pfam19057
    Location:601 → 750
    PH_19; PH domain
Nucleotide Protein
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