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SGCA sarcoglycan alpha [ Canis lupus familiaris (dog) ]

Gene ID: 609265, updated on 17-Aug-2024

Summary

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Official Symbol
SGCAprovided by VGNC
Official Full Name
sarcoglycan alphaprovided by VGNC
Primary source
VGNC:VGNC:46091
See related
Ensembl:ENSCAFG00845012386
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See SGCA in Genome Data Viewer
Location:
chromosome: 9
Exon count:
11
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 9 NC_051813.1 (26959303..26972755)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 9 NC_006591.4 (25557947..25571307)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 9 NC_049230.1 (26115697..26129096)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 9 NC_049269.1 (25727095..25740489)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 9 NC_049750.1 (25985773..25999153)

Chromosome 9 - NC_051813.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111097376 Neighboring gene protein phosphatase 1 regulatory subunit 9B Neighboring gene uncharacterized LOC119873287 Neighboring gene uncharacterized LOC106559295 Neighboring gene collagen type I alpha 1 chain Neighboring gene small nucleolar RNA U2-19

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sarcoglycan A mutation in miniature dachshund dogs causes limb-girdle muscular dystrophy 2D. Mickelson JR, et al. Skelet Muscle, 2021 Jan 7. PMID 33407862, Free PMC Article
  2. Selective vacuolar degeneration in dystrophin-deficient canine Purkinje fibers despite preservation of dystrophin-associated proteins with overexpression of Dp71. Urasawa N, et al. Circulation, 2008 May 13. PMID 18458171
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sarcoglycan A mutation in miniature dachshund dogs causes limb-girdle muscular dystrophy 2D.
    Title: Sarcoglycan A mutation in miniature dachshund dogs causes limb-girdle muscular dystrophy 2D.
  2. the expression of dystrophin-associated proteins alpha-, beta-, gamma-, and delta-sarcoglycans and beta-dystroglycan was well maintained at the sarcolemma of Purkinje fibers
    Title: Selective vacuolar degeneration in dystrophin-deficient canine Purkinje fibers despite preservation of dystrophin-associated proteins with overexpression of Dp71.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of sarcoglycan complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
alpha-sarcoglycan

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051813.1 Reference ROS_Cfam_1.0

    Range
    26959303..26972755
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038676839.1 → XP_038532767.1  alpha-sarcoglycan

    UniProtKB/TrEMBL
    A0A8C0LDI2, A0A8C0SAC5, A0A8I3NCD7, A0A8I3RZD4, A0A8P0P5Y0
    Related
    ENSCAFP00845017345.1, ENSCAFT00845022061.1
    Conserved Domains (1) summary
    pfam05510
    Location:8 → 347
    Sarcoglycan_2; Sarcoglycan alpha/epsilon

  2. XM_038676838.1 → XP_038532766.1  alpha-sarcoglycan

    UniProtKB/TrEMBL
    A0A8C0LDI2, A0A8C0SAC5, A0A8I3NCD7, A0A8I3RZD4, A0A8P0P5Y0
    Conserved Domains (1) summary
    pfam05510
    Location:8 → 347
    Sarcoglycan_2; Sarcoglycan alpha/epsilon

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049269.1 Alternate UMICH_Zoey_3.1

    Range
    25727095..25740489
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038485881.1 → XP_038341809.1  alpha-sarcoglycan

    Conserved Domains (1) summary
    pfam05510
    Location:8 → 347
    Sarcoglycan_2; Sarcoglycan alpha/epsilon

  2. XM_038485880.1 → XP_038341808.1  alpha-sarcoglycan

    Conserved Domains (1) summary
    pfam05510
    Location:8 → 347
    Sarcoglycan_2; Sarcoglycan alpha/epsilon

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049750.1 Alternate UNSW_CanFamBas_1.0

    Range
    25985773..25999153
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038611641.1 → XP_038467569.1  alpha-sarcoglycan

    Conserved Domains (1) summary
    pfam05510
    Location:8 → 347
    Sarcoglycan_2; Sarcoglycan alpha/epsilon

  2. XM_038611640.1 → XP_038467568.1  alpha-sarcoglycan

    Conserved Domains (1) summary
    pfam05510
    Location:8 → 347
    Sarcoglycan_2; Sarcoglycan alpha/epsilon

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049230.1 Alternate UU_Cfam_GSD_1.0

    Range
    26115697..26129096
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038547641.1 → XP_038403569.1  alpha-sarcoglycan

    UniProtKB/TrEMBL
    A0A8C0LDI2, A0A8C0SAC5, A0A8I3NCD7, A0A8I3RZD4, A0A8P0P5Y0
    Conserved Domains (1) summary
    pfam05510
    Location:8 → 347
    Sarcoglycan_2; Sarcoglycan alpha/epsilon

  2. XM_038547640.1 → XP_038403568.1  alpha-sarcoglycan

    UniProtKB/TrEMBL
    A0A8C0LDI2, A0A8C0SAC5, A0A8I3NCD7, A0A8I3RZD4, A0A8P0P5Y0
    Conserved Domains (1) summary
    pfam05510
    Location:8 → 347
    Sarcoglycan_2; Sarcoglycan alpha/epsilon

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006591.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    25557947..25571307
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005624636.4 → XP_005624693.1  alpha-sarcoglycan

    See identical proteins and their annotated locations for XP_005624693.1

    UniProtKB/TrEMBL
    A0A8C0LDI2, A0A8C0SAC5, A0A8I3NCD7, A0A8I3RZD4, A0A8P0P5Y0
    Conserved Domains (1) summary
    pfam05510
    Location:8 → 347
    Sarcoglycan_2; Sarcoglycan alpha/epsilon

  2. XM_005624635.3 → XP_005624692.1  alpha-sarcoglycan

    See identical proteins and their annotated locations for XP_005624692.1

    UniProtKB/TrEMBL
    A0A8C0LDI2, A0A8C0SAC5, A0A8I3NCD7, A0A8I3RZD4, A0A8P0P5Y0
    Conserved Domains (1) summary
    pfam05510
    Location:8 → 347
    Sarcoglycan_2; Sarcoglycan alpha/epsilon
Nucleotide Protein
Heading Accession and Version

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