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ROBO1 roundabout guidance receptor 1 [ Homo sapiens (human) ]

Gene ID: 6091, updated on 14-Nov-2024

Summary

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Official Symbol
ROBO1provided by HGNC
Official Full Name
roundabout guidance receptor 1provided by HGNC
Primary source
HGNC:HGNC:10249
See related
Ensembl:ENSG00000169855 MIM:602430; AllianceGenome:HGNC:10249
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NORS; NYS8; SAX3; CPHD8; DUTT1
Summary
Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Expression
Ubiquitous expression in brain (RPKM 11.9), skin (RPKM 9.4) and 23 other tissues See more
Orthologs
mouse all
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Genomic context

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See ROBO1 in Genome Data Viewer
Location:
3p12.3
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (78597239..79767998, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (78652524..79823991, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (78646389..79817148, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:78315096-78316295 Neighboring gene RN7SK pseudogene 61 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:78371863-78372653 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:78392873-78394072 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:78402403-78402950 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:78630276-78631137 Neighboring gene mitochondrial ribosomal protein S17 pseudogene 3 Neighboring gene Sharpr-MPRA regulatory region 7147 Neighboring gene Sharpr-MPRA regulatory region 6803 Neighboring gene ribosomal protein S12 pseudogene 6 Neighboring gene NANOG hESC enhancer GRCh37_chr3:79006574-79007156 Neighboring gene VISTA enhancer hs1475 Neighboring gene RNA, 7SL, cytoplasmic 751, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:79174827-79175326 Neighboring gene NANOG hESC enhancer GRCh37_chr3:79209960-79210461 Neighboring gene uncharacterized LOC101927374 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:79667239-79668438 Neighboring gene microRNA 3923 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:79914289-79914466 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:79986556-79987112 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:80101631-80102130 Neighboring gene high mobility group box 1 pseudogene 38 Neighboring gene oxysterol binding protein like 9 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Alterations of ROBO1/DUTT1 and ROBO2 loci in early dysplastic lesions of head and neck: clinical and prognostic implications. Ghosh S, et al. Hum Genet, 2009 Mar. PMID 19104841
  2. High structural resolution hydroxyl radical protein footprinting reveals an extended Robo1-heparin binding interface. Li Z, et al. J Biol Chem, 2015 Apr 24. PMID 25752613, Free PMC Article
  3. Cloning, expression, crystallization and preliminary X-ray analysis of the first two Ig domains from human roundabout 1 (Robo1). Morlot C, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2007 Aug 1. PMID 17671369, Free PMC Article
  4. Biallelic pathogenic variants in roundabout guidance receptor 1 associate with syndromic congenital anomalies of the kidney and urinary tract. Münch J, et al. Kidney Int, 2022 May. PMID 35227688, Free PMC Article
  5. ROBO1 deletion as a novel germline alteration in breast and colorectal cancer patients. Villacis RA, et al. Tumour Biol, 2016 Mar. PMID 26427657

See all (196) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Stromal Cell-SLIT3/Cardiomyocyte-ROBO1 Axis Regulates Pressure Overload-Induced Cardiac Hypertrophy.
    Title: Stromal Cell-SLIT3/Cardiomyocyte-ROBO1 Axis Regulates Pressure Overload-Induced Cardiac Hypertrophy.
  2. ROBO1 deficiency impairs HSPC homeostasis and erythropoiesis via CDC42 and predicts poor prognosis in MDS.
    Title: ROBO1 deficiency impairs HSPC homeostasis and erythropoiesis via CDC42 and predicts poor prognosis in MDS.
  3. MicroRNA-588 regulates the invasive, migratory and vasculogenic mimicry-forming abilities of hypoxic glioma cells by targeting ROBO1.
    Title: MicroRNA-588 regulates the invasive, migratory and vasculogenic mimicry-forming abilities of hypoxic glioma cells by targeting ROBO1.
  4. Tumor-Derived Exosomal miR-29b Reduces Angiogenesis in Pancreatic Cancer by Silencing ROBO1 and SRGAP2.
    Title: Tumor-Derived Exosomal miR-29b Reduces Angiogenesis in Pancreatic Cancer by Silencing ROBO1 and SRGAP2.
  5. NMR analysis suggests the terminal domains of Robo1 remain extended but are rigidified in the presence of heparan sulfate.
    Title: NMR analysis suggests the terminal domains of Robo1 remain extended but are rigidified in the presence of heparan sulfate.
  6. Identification of non-synonymous variations in ROBO1 and GATA5 genes in a family with bicuspid aortic valve disease.
    Title: Identification of non-synonymous variations in ROBO1 and GATA5 genes in a family with bicuspid aortic valve disease.
  7. Novel dominant and recessive variants in human ROBO1 cause distinct neurodevelopmental defects through different mechanisms.
    Title: Novel dominant and recessive variants in human ROBO1 cause distinct neurodevelopmental defects through different mechanisms.
  8. MiR-218 Targeted Regulation of Robol Expression Regulates Proliferation, Invasion and Migration of Glioma Cells.
    Title: MiR-218 Targeted Regulation of Robol Expression Regulates Proliferation, Invasion and Migration of Glioma Cells.
  9. An ancient founder mutation located between ROBO1 and ROBO2 is responsible for increased microtia risk in Amerindigenous populations.
    Title: An ancient founder mutation located between ROBO1 and ROBO2 is responsible for increased microtia risk in Amerindigenous populations.
  10. Biallelic pathogenic variants in roundabout guidance receptor 1 associate with syndromic congenital anomalies of the kidney and urinary tract.
    Title: Biallelic pathogenic variants in roundabout guidance receptor 1 associate with syndromic congenital anomalies of the kidney and urinary tract.
Submit: New GeneRIF Correction See all GeneRIFs (119)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Neurooculorenal syndrome
MedGen: C5830377 OMIM: 620305 GeneReviews: Not available
not available
Nystagmus, congenital, autosomal recessive
MedGen: C3151571 OMIM: 257400 GeneReviews: Not available
not available
Pituitary hormone deficiency, combined or isolated, 8
MedGen: C5830375 OMIM: 620303 GeneReviews: Not available
not available

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2018-09-25)

ClinGen Genome Curation Page
Haploinsufficency

No evidence available (Last evaluated 2018-09-25)

ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Description
A genome-wide association study identifies protein quantitative trait loci (pQTLs).
EBI GWAS Catalog
A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype.
EBI GWAS Catalog
Genome-wide association study of liver enzymes in korean children.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The N-terminal leucine-rich repeat fragment of Slit2 inhibits HIV-1 gp120-induced ROBO1-actin association PubMed
env Inhibition of M-tropic HIV-1 gp120-induced transendothelial migration by SLIT2N involves SLIT2N-mediated enhancement of co-localization of Robo1 with WASp and LSP1 in immature monocyte-derived dendritic cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ21882, MGC131599, MGC133277

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables LRR domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables axon guidance receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Roundabout signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in aorta development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in aortic valve morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in axon midline choice point recognition ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell adhesion TAS
Traceable Author Statement
more info
 PubMed 
involved_in cell migration involved in sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chemorepulsion involved in postnatal olfactory bulb interneuron migration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in endocardial cushion formation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in heart induction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of chemokine-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of mammary gland epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of negative chemotaxis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nervous system development TAS
Traceable Author Statement
more info
 PubMed 
involved_in outflow tract septum morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of MAP kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of Notch signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of Rho protein signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of axonogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cysteine-type endopeptidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of vascular endothelial growth factor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pulmonary valve morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ventricular septum morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
  
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum-Golgi intermediate compartment membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
roundabout homolog 1
Names
deleted in U twenty twenty
roundabout, axon guidance receptor, homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011729.1 RefSeqGene

    Range
    4912..1175671
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001145845.2 → NP_001139317.1  roundabout homolog 1 isoform d precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) represents use of an alternate promoter and 5' UTR, uses a distinct translation start site, includes an alternate in-frame exon in the 5' coding region, lacks an alternate in-frame exon in the central coding region, and uses an alternate splice site in the central coding region, compared to variant 1. The resulting isoform (d) has a shorter and distinct N-terminus and differs at three internal regions, compared to isoform a. The 5' UTR of this variant contains a 55 aa uORF with a strong Kozak signal that may inhibit translation of this protein.
    Source sequence(s)
    AC016946, AC055731, AC106720, AC108719, AK025535, BC115022, BP228659
    Consensus CDS
    CCDS54610.1
    UniProtKB/TrEMBL
    Q2M1J3
    Related
    ENSP00000417992.1, ENST00000467549.5
    Conserved Domains (7) summary
    cd00063
    Location:525 → 611
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:742 → 828
    fn3; Fibronectin type III domain
    cd05724
    Location:134 → 219
    IgI_2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
    cd05725
    Location:226 → 308
    IgI_3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
    cd05726
    Location:316 → 413
    IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
    cd07693
    Location:29 → 127
    IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
    cd20952
    Location:420 → 506
    IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains

  2. NM_002941.4 → NP_002932.1  roundabout homolog 1 isoform a precursor

    See identical proteins and their annotated locations for NP_002932.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC125624, AF040990, AK025535, DR003097
    Consensus CDS
    CCDS54611.1
    UniProtKB/Swiss-Prot
    B2RXI1, D3DU36, E9PD49, Q1RMC7, Q7Z300, Q9BUS7, Q9Y6N7
    UniProtKB/TrEMBL
    Q2M1J3
    Related
    ENSP00000420321.1, ENST00000464233.6
    Conserved Domains (8) summary
    cd05724
    Location:174 → 258
    Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd05725
    Location:279 → 347
    Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd05726
    Location:365 → 454
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd07693
    Location:67 → 166
    Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
    cd00063
    Location:561 → 647
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:262 → 347
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:778 → 864
    fn3; Fibronectin type III domain
    cl11960
    Location:459 → 533
    Ig; Immunoglobulin domain

  3. NM_133631.4 → NP_598334.2  roundabout homolog 1 isoform b precursor

    See identical proteins and their annotated locations for NP_598334.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR, uses a distinct translation start site, includes an alternate in-frame exon in the 5' coding region, and lacks an alternate in-frame exon in the central coding region, compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus, compared to isoform a. The 5' UTR of this variant contains a 55 aa uORF with a strong Kozak signal that may inhibit translation of this protein.
    Source sequence(s)
    AC016946, BC029676, BC115020, BC157861, BP228659
    Consensus CDS
    CCDS46872.2
    UniProtKB/TrEMBL
    Q2M1J3
    Related
    ENSP00000420637.1, ENST00000495273.5
    Conserved Domains (8) summary
    cd05724
    Location:135 → 219
    Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd05725
    Location:240 → 308
    Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd05726
    Location:329 → 418
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd07693
    Location:28 → 127
    Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
    cd00063
    Location:525 → 611
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:223 → 308
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:742 → 828
    fn3; Fibronectin type III domain
    cl11960
    Location:423 → 497
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    78597239..79767998 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017006982.2 → XP_016862471.1  roundabout homolog 1 isoform X4

    UniProtKB/TrEMBL
    Q2M1J3

  2. XM_047448664.1 → XP_047304620.1  roundabout homolog 1 isoform X12

  3. XM_047448661.1 → XP_047304617.1  roundabout homolog 1 isoform X3

  4. XM_017006984.1 → XP_016862473.1  roundabout homolog 1 isoform X10

    UniProtKB/TrEMBL
    Q2M1J3

  5. XM_011533980.1 → XP_011532282.1  roundabout homolog 1 isoform X11

    UniProtKB/TrEMBL
    Q2M1J3
    Conserved Domains (8) summary
    cd05724
    Location:174 → 258
    Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd05725
    Location:279 → 347
    Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd05726
    Location:368 → 457
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd07693
    Location:67 → 166
    Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
    cd00063
    Location:564 → 650
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:262 → 347
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:781 → 867
    fn3; Fibronectin type III domain
    cl11960
    Location:462 → 536
    Ig; Immunoglobulin domain

  6. XM_011533978.1 → XP_011532280.1  roundabout homolog 1 isoform X2

    UniProtKB/TrEMBL
    Q2M1J3
    Conserved Domains (8) summary
    cd05724
    Location:174 → 258
    Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd05725
    Location:279 → 347
    Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd05726
    Location:368 → 457
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd07693
    Location:67 → 166
    Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
    cd00063
    Location:564 → 650
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:262 → 347
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:781 → 867
    fn3; Fibronectin type III domain
    cl11960
    Location:462 → 536
    Ig; Immunoglobulin domain

  7. XM_011533979.1 → XP_011532281.1  roundabout homolog 1 isoform X9

    UniProtKB/TrEMBL
    Q2M1J3
    Conserved Domains (8) summary
    cd05724
    Location:174 → 258
    Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd05725
    Location:279 → 347
    Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd05726
    Location:368 → 457
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd07693
    Location:67 → 166
    Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
    cd00063
    Location:564 → 650
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:262 → 347
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:781 → 867
    fn3; Fibronectin type III domain
    cl11960
    Location:462 → 536
    Ig; Immunoglobulin domain

  8. XM_011533976.1 → XP_011532278.1  roundabout homolog 1 isoform X1

    See identical proteins and their annotated locations for XP_011532278.1

    UniProtKB/TrEMBL
    Q2M1J3
    Conserved Domains (8) summary
    cd05724
    Location:174 → 258
    Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd05725
    Location:279 → 347
    Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd05726
    Location:368 → 457
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd07693
    Location:67 → 166
    Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
    cd00063
    Location:564 → 650
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:262 → 347
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:781 → 867
    fn3; Fibronectin type III domain
    cl11960
    Location:462 → 536
    Ig; Immunoglobulin domain

  9. XM_011533977.3 → XP_011532279.1  roundabout homolog 1 isoform X1

    See identical proteins and their annotated locations for XP_011532279.1

    UniProtKB/TrEMBL
    Q2M1J3
    Conserved Domains (8) summary
    cd05724
    Location:174 → 258
    Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd05725
    Location:279 → 347
    Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd05726
    Location:368 → 457
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd07693
    Location:67 → 166
    Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
    cd00063
    Location:564 → 650
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:262 → 347
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:781 → 867
    fn3; Fibronectin type III domain
    cl11960
    Location:462 → 536
    Ig; Immunoglobulin domain

  10. XM_047448665.1 → XP_047304621.1  roundabout homolog 1 isoform X13

  11. XM_047448663.1 → XP_047304619.1  roundabout homolog 1 isoform X8

  12. XM_017006983.3 → XP_016862472.1  roundabout homolog 1 isoform X7

    UniProtKB/TrEMBL
    Q2M1J3
    Related
    ENSP00000406043.3, ENST00000436010.6
    Conserved Domains (8) summary
    cd05724
    Location:135 → 219
    Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd05725
    Location:240 → 308
    Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd05726
    Location:326 → 415
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd07693
    Location:28 → 127
    Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
    cd00063
    Location:522 → 608
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:223 → 308
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:739 → 825
    fn3; Fibronectin type III domain
    cl11960
    Location:420 → 494
    Ig; Immunoglobulin domain

  13. XM_006713277.4 → XP_006713340.1  roundabout homolog 1 isoform X5

    UniProtKB/TrEMBL
    Q2M1J3
    Conserved Domains (8) summary
    cd05724
    Location:135 → 219
    Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd05725
    Location:240 → 308
    Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd05726
    Location:329 → 418
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd07693
    Location:28 → 127
    Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
    cd00063
    Location:525 → 611
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:223 → 308
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:742 → 828
    fn3; Fibronectin type III domain
    cl11960
    Location:423 → 497
    Ig; Immunoglobulin domain

  14. XM_017006985.2 → XP_016862474.1  roundabout homolog 1 isoform X14

    UniProtKB/TrEMBL
    A0A0A0MSX4

  15. XM_047448662.1 → XP_047304618.1  roundabout homolog 1 isoform X6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    78652524..79823991 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054347447.1 → XP_054203422.1  roundabout homolog 1 isoform X4

  2. XM_054347455.1 → XP_054203430.1  roundabout homolog 1 isoform X12

  3. XM_054347446.1 → XP_054203421.1  roundabout homolog 1 isoform X3

  4. XM_054347453.1 → XP_054203428.1  roundabout homolog 1 isoform X10

  5. XM_054347454.1 → XP_054203429.1  roundabout homolog 1 isoform X11

  6. XM_054347445.1 → XP_054203420.1  roundabout homolog 1 isoform X2

  7. XM_054347452.1 → XP_054203427.1  roundabout homolog 1 isoform X9

  8. XM_054347443.1 → XP_054203418.1  roundabout homolog 1 isoform X1

  9. XM_054347444.1 → XP_054203419.1  roundabout homolog 1 isoform X1

  10. XM_054347456.1 → XP_054203431.1  roundabout homolog 1 isoform X13

  11. XM_054347451.1 → XP_054203426.1  roundabout homolog 1 isoform X8

  12. XM_054347450.1 → XP_054203425.1  roundabout homolog 1 isoform X7

  13. XM_054347448.1 → XP_054203423.1  roundabout homolog 1 isoform X5

  14. XM_054347449.1 → XP_054203424.1  roundabout homolog 1 isoform X6

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y6N7.1 GenPept UniProtKB/Swiss-Prot:Q9Y6N7

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