F7 coagulation factor VII [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: F7provided by VGNC
Official Full Name: coagulation factor VIIprovided by VGNC
Primary source: VGNC:VGNC:40552
See related: Ensembl:ENSCAFG00845024066
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 22

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	22	NC_051826.1 (61197920..61208435)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	22	NC_006604.4 (60285105..60295147)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	22	NC_049243.1 (60729611..60740074)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	22	NC_049282.1 (60696588..60706712)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	22	NC_049763.1 (60698754..60708987)

Chromosome 22 - NC_051826.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

F7-G96E dogs are a model of type I F7 deficiency. Canine F7 gene delivery in F7-G96E dogs via adeno-associated viral mediated expression of zymogen F7 at a dose effective in humans showed stable and clinically therapeutic F7 expression.
Title: Sustained correction of FVII deficiency in dogs using AAV-mediated expression of zymogen FVII.
analysis of coagulation factor VII and its complex formation with tissue factor in dog and human
Title: Characterization of canine coagulation factor VII and its complex formation with tissue factor: canine-human cross-species compatibility.
Vector delivery via the portal vein in hemophilia A and B dogs was well tolerated, and long-term expression of cFVIIa resulted in a shortening of the prothrombin time, partial correction of the whole blood clotting time and thromboelastography parameters
Title: Successful treatment of canine hemophilia by continuous expression of canine FVIIa.
Identified missense mutation causing canine factor VII deficiency and altered blood coagulation.
Title: A novel missense mutation responsible for factor VII deficiency in research Beagle colonies.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

F7 (e-PCR), detects polymorphism
- UniSTS:263466

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in blood coagulation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: coagulation factor VII

Names: coagulation factor VII (serum prothrombin conversion accelerator)

NP_001041498.1

EC 3.4.21.21

XP_038286715.1

EC 3.4.21.21

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001048033.1 → NP_001041498.1 coagulation factor VII precursor

See identical proteins and their annotated locations for NP_001041498.1

Status: PROVISIONAL

Source sequence(s)

DQ223901

UniProtKB/TrEMBL

A0A8C0L1U8, Q38J75

Related

ENSCAFP00845033343.1, ENSCAFT00845042535.1

Conserved Domains (5) summary

smart00020
Location:192 → 426

Tryp_SPc; Trypsin-like serine protease

smart00069
Location:22 → 85

GLA; Domain containing Gla (gamma-carboxyglutamate) residues

cd00054
Location:86 → 122

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00190
Location:193 → 429

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam14670
Location:131 → 167

FXa_inhibition; Coagulation Factor Xa inhibitory site

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051826.1 Reference ROS_Cfam_1.0

Range

61197920..61208435

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038430787.1 → XP_038286715.1 coagulation factor VII isoform X1

UniProtKB/TrEMBL

A0A8C0RSI9

Conserved Domains (3) summary

cd00054
Location:28 → 64

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00190
Location:135 → 371

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam14670
Location:73 → 109

FXa_inhibition; Coagulation Factor Xa inhibitory site