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Hspa2 heat shock protein family A (Hsp70) member 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 60460, updated on 2-Nov-2024

Summary

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Official Symbol
Hspa2provided by RGD
Official Full Name
heat shock protein family A (Hsp70) member 2provided by RGD
Primary source
RGD:620664
See related
EnsemblRapid:ENSRNOG00000006472 AllianceGenome:RGD:620664
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Hst70; Hspt70
Summary
Enables protein-folding chaperone binding activity and tau protein binding activity. Predicted to be involved in several processes, including negative regulation of inclusion body assembly; positive regulation of ATPase-coupled calcium transmembrane transporter activity; and protein folding. Predicted to act upstream of or within several processes, including male meiosis I; positive regulation of G2/M transition of mitotic cell cycle; and synaptonemal complex disassembly. Predicted to be located in cell surface; meiotic spindle; and nucleus. Predicted to be part of CatSper complex. Predicted to be active in cytosol; nucleus; and plasma membrane. Orthologous to human HSPA2 (heat shock protein family A (Hsp70) member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 1456.3) and Kidney (RPKM 68.2) See more
Orthologs
human mouse all
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Genomic context

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See Hspa2 in Genome Data Viewer
Location:
6q24
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (100864172..100866946)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (95128504..95131281)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (99433575..99436288)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 25 Neighboring gene zinc finger and BTB domain containing 1 Neighboring gene uncharacterized LOC120103556 Neighboring gene protein phosphatase 1, regulatory subunit 36 Neighboring gene uncharacterized LOC102556012

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Evaluation of heat-shock protein A2 (HSPA2) in male rats before and after varicocele induction. Afiyani AA, et al. Mol Reprod Dev, 2014 Aug. PMID 25043441
  2. Isolation and nucleotide sequence analysis of the rat testis-specific major heat-shock protein (HSP70)-related gene. Wiśniewski J, et al. Biochim Biophys Acta, 1990 Jan 30. PMID 1688714
  3. Expression and sulfogalactolipid binding specificity of the recombinant testis-specific cognate heat shock protein 70. Mamelak D, et al. Glycoconj J, 1997 Sep. PMID 9337084
  4. HSP70-2 is required for desynapsis of synaptonemal complexes during meiotic prophase in juvenile and adult mouse spermatocytes. Dix DJ, et al. Development, 1997 Nov. PMID 9409676
  5. Location of promoter elements necessary and sufficient to direct testis-specific expression of the Hst70/Hsp70.2 gene. Scieglińska D, et al. Biochem J, 2004 May 1. PMID 14766014, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HSPA2 abundance increased whereas ubiquitin expression reduced in the affected testis of a rat varicocele model.
    Title: Evaluation of heat-shock protein A2 (HSPA2) in male rats before and after varicocele induction.
  2. high-level testis-specific gene expression requires additional sequences localized upstream of the T2 transcription start site
    Title: Location of promoter elements necessary and sufficient to direct testis-specific expression of the Hst70/Hsp70.2 gene.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC93458

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
  
enables disordered domain specific binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables glycolipid binding ISO
Inferred from Sequence Orthology
more info
  
enables heat shock protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein folding chaperone IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-folding chaperone binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables tau protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables unfolded protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in chaperone cofactor-dependent protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within male meiosis I ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within male meiotic nuclear division ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of inclusion body assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of ATP-dependent activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of ATPase-coupled calcium transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of ATPase-coupled calcium transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein refolding ISO
Inferred from Sequence Orthology
more info
  
involved_in response to cold ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to heat ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within spermatid development ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within synaptonemal complex disassembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of CatSper complex ISO
Inferred from Sequence Orthology
more info
  
part_of CatSper complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in male germ cell nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in meiotic spindle ISO
Inferred from Sequence Orthology
more info
  
located_in meiotic spindle ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synaptonemal complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
heat shock-related 70 kDa protein 2
Names
HST
heat shock 70kDa protein 2
heat shock protein 2
heat shock protein 70.2
heat shock protein alpha 2
heat shock protein family A member 2
testis-specific heat shock protein-related gene hst70

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001433314.1 → NP_001420243.1  heat shock-related 70 kDa protein 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/Swiss-Prot
    P14659, Q66HL1
    UniProtKB/TrEMBL
    A6HCA7

  2. NM_021863.3 → NP_068635.1  heat shock-related 70 kDa protein 2

    See identical proteins and their annotated locations for NP_068635.1

    Status: VALIDATED

    Source sequence(s)
    X15705
    UniProtKB/Swiss-Prot
    P14659
    Related
    ENSRNOP00000008504.3, ENSRNOT00000008504.7
    Conserved Domains (2) summary
    cd10233
    Location:7 → 383
    HSPA1-2_6-8-like_NBD; Nucleotide-binding domain of HSPA1-A, -B, -L, HSPA-2, -6, -7, -8, and similar proteins
    PTZ00009
    Location:2 → 615
    PTZ00009; heat shock 70 kDa protein; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    100864172..100866946
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006240247.5 → XP_006240309.1  heat shock-related 70 kDa protein 2 isoform X1

    Conserved Domains (1) summary
    PTZ00009
    Location:2 → 615
    PTZ00009; heat shock 70 kDa protein; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P14659.2 GenPept UniProtKB/Swiss-Prot:P14659

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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