Nrxn1 neurexin 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 60391, updated on 2-Nov-2024

Summary

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Symbol: Nrxn1provided by RGD
Full Name: neurexin 1provided by RGD
Primary source: RGD:628659
See related: EnsemblRapid:ENSRNOG00000050220 AllianceGenome:RGD:628659
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Nrxn1b
Summary: This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are synaptic transmembrane receptors that bind endogenous ligands that include neuroligins, dystroglycan, and neurexophilins. Neurexin complexes are required for efficient neurotransmission and are involved in synaptogenesis. In vertebrates, alternate promoter usage results in multiple isoform classes, of which the alpha and beta classes are the best characterized. In humans, allelic variants in this gene are associated with Pitt-Hopkins-like syndrome-2, while deletions have been associated with autism and schizophrenia. Mouse knockouts display decreased spontaneous and evoked vesicle release resulting in impaired synaptic transmission. In addition, knockout mice show altered social approach, reduced social investigation, reduced locomotor activity, and in males, increased aggression. [provided by RefSeq, Nov 2016]
Annotation information: Note: There is an assembly problem in the Rnor_6.0 reference genome assembly, and therefore, annotation of this gene is split across NW_007905831.1, NW_007905830.1, and NW_007905829.1 in NCBI's Rattus norvegicus Annotation Release 105. [17 Jun 2015]
Expression: Biased expression in Brain (RPKM 575.7), Lung (RPKM 89.2) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Nrxn1 in Genome Data Viewer

Location:: 6q11-q12

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (8931360..10077381)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (3177788..4323848)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (13886757..15191660, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neurexin1alpha knockout rats display oscillatory abnormalities and sensory processing deficits back-translating key endophenotypes of psychiatric disorders.
Title: Neurexin1α knockout rats display oscillatory abnormalities and sensory processing deficits back-translating key endophenotypes of psychiatric disorders.
Upregulation of Hevin contributes to postoperative pain hypersensitivity by inducing neurexin1beta/neuroligin1-mediated synaptic targeting of GluA1-containing AMPA receptors in rat dorsal horn.
Title: Upregulation of Hevin contributes to postoperative pain hypersensitivity by inducing neurexin1β/neuroligin1-mediated synaptic targeting of GluA1-containing AMPA receptors in rat dorsal horn.
The protective effect and potential mechanism of NRXN1 on learning and memory in ADHD rat models.
Title: The protective effect and potential mechanism of NRXN1 on learning and memory in ADHD rat models.
SorCS1-mediated sorting in dendritic endosomes controls Nrxn axonal surface polarization required for proper synapse development and function.
Title: SorCS1-mediated sorting in dendrites maintains neurexin axonal surface polarization required for synaptic function.
Results determined the crystal structures of the trimeric C1q-like domain of cerebellin-1, and the first complete ectodomain of GluD2. Cerebellin binds to the LNS6 domain of alpha- and beta-neurexin-1 through a high-affinity interaction that involves its highly flexible N-terminal domain.
Title: Conformational Plasticity in the Transsynaptic Neurexin-Cerebellin-Glutamate Receptor Adhesion Complex.
study supports the hypothesis that developmental hypothyroxinemia and hypothyroidism reduce PF-PC synapses, which may be attributed to the downregulation of Neurexin1/Cbln1/GluD2 tripartite complex.
Title: Developmental Hypothyroxinemia and Hypothyroidism Reduce Parallel Fiber-Purkinje Cell Synapses in Rat Offspring by Downregulation of Neurexin1/Cbln1/GluD2 Tripartite Complex.
Structural and functional analyses of the sixth site of neurexin alternative splicing
Title: Structural and functional analyses of the sixth site of neurexin alternative splicing.
structure of Calsyntenin 3 and its interaction with neurexin 1alpha
Title: Calsyntenin-3 molecular architecture and interaction with neurexin 1α.
Dystroglycan binding to alpha-neurexin competes with neurexophilin-1 and neuroligin in the brain.
Title: Dystroglycan binding to α-neurexin competes with neurexophilin-1 and neuroligin in the brain.
The results showed that AChE clusters colocalized with neurexin assemblies in the neurites of hippocampal neurons.
Title: Interaction of acetylcholinesterase with neurexin-1β regulates glutamatergic synaptic stability in hippocampal neurons.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-F02322 (e-PCR)
- UniSTS:43070

d6rat151 (e-PCR)
- UniSTS:122222

d6rat47 (e-PCR)
- UniSTS:122250

RH143359 (e-PCR)
- UniSTS:232606

D6Rat212 (e-PCR), detects polymorphism
- UniSTS:228049

RH142000 (e-PCR)
- UniSTS:223991

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables acetylcholine receptor binding	IEA Inferred from Electronic Annotation more info
enables acetylcholine receptor binding	ISO Inferred from Sequence Orthology more info
enables acetylcholine receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables calcium channel regulator activity	IEA Inferred from Electronic Annotation more info
enables calcium channel regulator activity	ISO Inferred from Sequence Orthology more info
enables calcium channel regulator activity	ISS Inferred from Sequence or Structural Similarity more info
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables calcium-dependent protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables cell adhesion molecule binding	IEA Inferred from Electronic Annotation more info
enables cell adhesion molecule binding	IPI Inferred from Physical Interaction more info	PubMed
enables cell adhesion molecule binding	ISO Inferred from Sequence Orthology more info
enables cell adhesion molecule binding	ISS Inferred from Sequence or Structural Similarity more info
enables neuroligin family protein binding	IEA Inferred from Electronic Annotation more info
enables neuroligin family protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables neuroligin family protein binding	ISO Inferred from Sequence Orthology more info
enables neuroligin family protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane signaling receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane signaling receptor activity	ISO Inferred from Sequence Orthology more info
enables type 1 fibroblast growth factor receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of AMPA selective glutamate receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in NMDA glutamate receptor clustering	ISO Inferred from Sequence Orthology more info
involved_in NMDA glutamate receptor clustering	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of NMDA selective glutamate receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in adult behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of adult behavior	ISO Inferred from Sequence Orthology more info
involved_in adult behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of adult behavior	ISS Inferred from Sequence or Structural Similarity more info
involved_in angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	ISO Inferred from Sequence Orthology more info
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	ISS Inferred from Sequence or Structural Similarity more info
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	NAS Non-traceable Author Statement more info	PubMed
involved_in cell-cell adhesion involved in synapse maturation	NAS Non-traceable Author Statement more info	PubMed
involved_in cellular response to calcium ion	IDA Inferred from Direct Assay more info	PubMed
involved_in cerebellar granule cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in cerebellar granule cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in chemical synaptic transmission	ISS Inferred from Sequence or Structural Similarity more info
involved_in circadian rhythm	IEP Inferred from Expression Pattern more info	PubMed
involved_in establishment of protein localization	ISO Inferred from Sequence Orthology more info
involved_in establishment of protein localization	ISS Inferred from Sequence or Structural Similarity more info
involved_in filopodium assembly	ISO Inferred from Sequence Orthology more info
involved_in gamma-aminobutyric acid receptor clustering	ISO Inferred from Sequence Orthology more info
involved_in gamma-aminobutyric acid receptor clustering	ISS Inferred from Sequence or Structural Similarity more info
involved_in gephyrin clustering involved in postsynaptic density assembly	IEA Inferred from Electronic Annotation more info
involved_in gephyrin clustering involved in postsynaptic density assembly	ISO Inferred from Sequence Orthology more info
involved_in gephyrin clustering involved in postsynaptic density assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in guanylate kinase-associated protein clustering	ISO Inferred from Sequence Orthology more info
involved_in guanylate kinase-associated protein clustering	ISS Inferred from Sequence or Structural Similarity more info
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	ISO Inferred from Sequence Orthology more info
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	ISS Inferred from Sequence or Structural Similarity more info
involved_in learning	IEA Inferred from Electronic Annotation more info
acts_upstream_of learning	ISO Inferred from Sequence Orthology more info
involved_in learning	ISO Inferred from Sequence Orthology more info
acts_upstream_of learning	ISS Inferred from Sequence or Structural Similarity more info
involved_in maintenance of synapse structure	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of filopodium assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of filopodium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in neuroligin clustering involved in postsynaptic membrane assembly	IEA Inferred from Electronic Annotation more info
involved_in neuroligin clustering involved in postsynaptic membrane assembly	ISO Inferred from Sequence Orthology more info
involved_in neuroligin clustering involved in postsynaptic membrane assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuromuscular process controlling balance	IEA Inferred from Electronic Annotation more info
NOT involved_in neuromuscular process controlling balance	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuromuscular process controlling balance	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuromuscular process controlling balance	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in neuron cell-cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron cell-cell adhesion	NAS Non-traceable Author Statement more info	PubMed
involved_in neuron cell-cell adhesion	TAS Traceable Author Statement more info	PubMed
involved_in neuron maturation	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in neuron projection morphogenesis	NAS Non-traceable Author Statement more info	PubMed
involved_in neurotransmitter secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neurotransmitter secretion	ISO Inferred from Sequence Orthology more info
involved_in neurotransmitter secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of excitatory postsynaptic potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of fibroblast growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuromuscular synaptic transmission	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of neuron projection development	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of presynaptic active zone assembly	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of protein kinase A signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of synapse assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synapse assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of synapse assembly	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of synapse maturation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of synapse maturation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synapse maturation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of synaptic transmission, GABAergic	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of synaptic transmission, glutamatergic	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of synaptic transmission, glutamatergic	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic transmission, glutamatergic	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of synaptic transmission, glutamatergic	NAS Non-traceable Author Statement more info	PubMed
involved_in postsynaptic density protein 95 clustering	IEA Inferred from Electronic Annotation more info
involved_in postsynaptic density protein 95 clustering	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic density protein 95 clustering	ISS Inferred from Sequence or Structural Similarity more info
involved_in postsynaptic membrane assembly	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic membrane assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in prepulse inhibition	IEA Inferred from Electronic Annotation more info
involved_in prepulse inhibition	ISO Inferred from Sequence Orthology more info
involved_in prepulse inhibition	ISS Inferred from Sequence or Structural Similarity more info
involved_in presynapse assembly	EXP Inferred from Experiment more info	PubMed
involved_in presynapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in presynapse assembly	IEA Inferred from Electronic Annotation more info
involved_in presynapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in presynapse assembly	ISO Inferred from Sequence Orthology more info
involved_in presynaptic membrane assembly	ISO Inferred from Sequence Orthology more info
involved_in presynaptic membrane assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to synapse	ISO Inferred from Sequence Orthology more info
involved_in protein localization to synapse	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein-containing complex assembly involved in synapse maturation	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex assembly involved in synapse maturation	ISS Inferred from Sequence or Structural Similarity more info
involved_in receptor localization to synapse	ISO Inferred from Sequence Orthology more info
involved_in receptor localization to synapse	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of AMPA receptor activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of NMDA receptor activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of grooming behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of regulation of grooming behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of regulation of grooming behavior	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of postsynaptic density assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of postsynaptic density assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic specialization assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of presynapse assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of presynapse assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic vesicle cycle	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic vesicle cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	ISO Inferred from Sequence Orthology more info
involved_in social behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of synapse assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in synapse assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in synapse assembly	NAS Non-traceable Author Statement more info	PubMed
involved_in synapse maturation	NAS Non-traceable Author Statement more info	PubMed
involved_in synaptic membrane adhesion	IEA Inferred from Electronic Annotation more info
involved_in synaptic membrane adhesion	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle clustering	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle clustering	ISS Inferred from Sequence or Structural Similarity more info
involved_in trans-synaptic signaling, modulating synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in trans-synaptic signaling, modulating synaptic transmission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vesicle docking involved in exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vocal learning	ISO Inferred from Sequence Orthology more info
involved_in vocalization behavior	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in GABA-ergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
located_in GABA-ergic synapse	NAS Non-traceable Author Statement more info	PubMed
located_in Schaffer collateral - CA1 synapse	IEA Inferred from Electronic Annotation more info
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
located_in axonal growth cone	ISO Inferred from Sequence Orthology more info
located_in axonal growth cone	ISS Inferred from Sequence or Structural Similarity more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISS Inferred from Sequence or Structural Similarity more info
located_in endocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in excitatory synapse	NAS Non-traceable Author Statement more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in glutamatergic synapse	NAS Non-traceable Author Statement more info	PubMed
located_in inhibitory synapse	NAS Non-traceable Author Statement more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuromuscular junction	NAS Non-traceable Author Statement more info	PubMed
located_in neuron to neuron synapse	NAS Non-traceable Author Statement more info	PubMed
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	NAS Non-traceable Author Statement more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
located_in presynaptic active zone membrane	IEA Inferred from Electronic Annotation more info
is_active_in presynaptic active zone membrane	ISO Inferred from Sequence Orthology more info
located_in presynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in presynaptic membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in presynaptic membrane	TAS Traceable Author Statement more info	PubMed
part_of protein complex involved in cell-cell adhesion	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in slit diaphragm	IDA Inferred from Direct Assay more info	PubMed
located_in vesicle	IEA Inferred from Electronic Annotation more info
located_in vesicle	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: neurexin-1

Names: 60S ribosomal protein L10a pseudogene; neurexin I-alpha; neurexin I-beta; neurexin-1-alpha; neurexin-1-beta; non-processed neurexin I-alpha

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001434104.1 → NP_001421033.1 neurexin-1 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006
NM_001434105.1 → NP_001421034.1 neurexin-1 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006
NM_001434106.1 → NP_001421035.1 neurexin-1 isoform 4 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006
NM_001434107.1 → NP_001421036.1 neurexin-1 isoform 5 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006
NM_001434108.1 → NP_001421037.1 neurexin-1 isoform 6 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006
NM_001434109.1 → NP_001421038.1 neurexin-1 isoform 7 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006
NM_001434110.1 → NP_001421039.1 neurexin-1 isoform 8

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006
NM_001434111.1 → NP_001421040.1 neurexin-1 isoform 9

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006
NM_001434112.1 → NP_001421041.1 neurexin-1 isoform 10

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006
NM_001434113.1 → NP_001421042.1 neurexin-1 isoform 11

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006
NM_021767.4 → NP_068535.3 neurexin-1 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

M0RBN6

Related

ENSRNOP00000093237.2, ENSRNOT00000095577.2

Conserved Domains (6) summary

smart00294
Location:1452 → 1470

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:503 → 652

LamG; Laminin G domain

cd00054
Location:680 → 713

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:30 → 190

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1432 → 1467

Syndecan; Syndecan domain

pfam02210
Location:933 → 1061

Laminin_G_2; Laminin G domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

8931360..10077381

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063262405.1 → XP_063118475.1 neurexin-1 isoform X1
XM_063262407.1 → XP_063118477.1 neurexin-1 isoform X3
XM_063262423.1 → XP_063118493.1 neurexin-1 isoform X24
XM_063262425.1 → XP_063118495.1 neurexin-1 isoform X26
XM_063262410.1 → XP_063118480.1 neurexin-1 isoform X7
XM_063262413.1 → XP_063118483.1 neurexin-1 isoform X10
XM_063262411.1 → XP_063118481.1 neurexin-1 isoform X8
XM_039112815.2 → XP_038968743.1 neurexin-1 isoform X6

UniProtKB/TrEMBL

M0RBN6

Conserved Domains (6) summary

smart00294
Location:1461 → 1479

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:503 → 652

LamG; Laminin G domain

cd00054
Location:680 → 713

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:30 → 190

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1441 → 1476

Syndecan; Syndecan domain

pfam02210
Location:933 → 1061

Laminin_G_2; Laminin G domain
XM_039112822.2 → XP_038968750.1 neurexin-1 isoform X12

UniProtKB/TrEMBL

M0RBN6

Related

ENSRNOP00000093870.2, ENSRNOT00000096505.2

Conserved Domains (6) summary

smart00294
Location:1452 → 1470

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:503 → 652

LamG; Laminin G domain

cd00054
Location:680 → 713

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:30 → 190

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1432 → 1467

Syndecan; Syndecan domain

pfam02210
Location:933 → 1061

Laminin_G_2; Laminin G domain
XM_063262415.1 → XP_063118485.1 neurexin-1 isoform X14

UniProtKB/TrEMBL

A0A8I6GKH3
XM_063262419.1 → XP_063118489.1 neurexin-1 isoform X20
XM_039112821.2 → XP_038968749.1 neurexin-1 isoform X11

UniProtKB/TrEMBL

M0RBN6

Conserved Domains (6) summary

smart00294
Location:1453 → 1471

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:495 → 644

LamG; Laminin G domain

cd00054
Location:672 → 705

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:30 → 190

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1433 → 1468

Syndecan; Syndecan domain

pfam02210
Location:925 → 1053

Laminin_G_2; Laminin G domain
XM_039112829.2 → XP_038968757.1 neurexin-1 isoform X19

UniProtKB/TrEMBL

M0RBN6

Conserved Domains (6) summary

smart00294
Location:1444 → 1462

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:495 → 644

LamG; Laminin G domain

cd00054
Location:672 → 705

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:30 → 190

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1424 → 1459

Syndecan; Syndecan domain

pfam02210
Location:925 → 1053

Laminin_G_2; Laminin G domain
XM_063262420.1 → XP_063118490.1 neurexin-1 isoform X21

UniProtKB/TrEMBL

A0A8I6GKK5
XM_063262408.1 → XP_063118478.1 neurexin-1 isoform X4
XM_039112828.2 → XP_038968756.1 neurexin-1 isoform X18

UniProtKB/TrEMBL

A0A0U1RRR4, M0RBN6

Conserved Domains (6) summary

smart00294
Location:1445 → 1463

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:499 → 648

LamG; Laminin G domain

cd00054
Location:676 → 709

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:30 → 190

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1425 → 1460

Syndecan; Syndecan domain

pfam02210
Location:929 → 1057

Laminin_G_2; Laminin G domain
XM_063262416.1 → XP_063118486.1 neurexin-1 isoform X15
XM_063262418.1 → XP_063118488.1 neurexin-1 isoform X17
XM_063262432.1 → XP_063118502.1 neurexin-1 isoform X33
XM_063262433.1 → XP_063118503.1 neurexin-1 isoform X34
XM_039112834.2 → XP_038968762.1 neurexin-1 isoform X22

UniProtKB/TrEMBL

M0RBN6

Conserved Domains (6) summary

smart00294
Location:1440 → 1458

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:491 → 640

LamG; Laminin G domain

cd00054
Location:668 → 701

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:30 → 190

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1420 → 1455

Syndecan; Syndecan domain

pfam02210
Location:921 → 1049

Laminin_G_2; Laminin G domain
XM_063262424.1 → XP_063118494.1 neurexin-1 isoform X25
XM_039112838.2 → XP_038968766.1 neurexin-1 isoform X36

UniProtKB/TrEMBL

A0A8I6A146

Related

ENSRNOP00000084025.2, ENSRNOT00000105104.2

Conserved Domains (6) summary

smart00294
Location:1410 → 1428

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:491 → 640

LamG; Laminin G domain

cd00054
Location:668 → 701

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:30 → 190

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1390 → 1425

Syndecan; Syndecan domain

pfam02210
Location:921 → 1049

Laminin_G_2; Laminin G domain
XM_063262435.1 → XP_063118505.1 neurexin-1 isoform X37
XM_063262422.1 → XP_063118492.1 neurexin-1 isoform X23
XM_063262427.1 → XP_063118497.1 neurexin-1 isoform X28
XM_063262406.1 → XP_063118476.1 neurexin-1 isoform X2
XM_063262414.1 → XP_063118484.1 neurexin-1 isoform X13
XM_063262409.1 → XP_063118479.1 neurexin-1 isoform X5
XM_063262412.1 → XP_063118482.1 neurexin-1 isoform X9
XM_039112841.2 → XP_038968769.1 neurexin-1 isoform X39

UniProtKB/TrEMBL

A0A8I6A146

Conserved Domains (6) summary

smart00294
Location:1392 → 1410

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:485 → 634

LamG; Laminin G domain

cd00054
Location:662 → 695

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:30 → 190

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1372 → 1407

Syndecan; Syndecan domain

pfam02210
Location:906 → 1034

Laminin_G_2; Laminin G domain
XM_063262417.1 → XP_063118487.1 neurexin-1 isoform X16
XM_063262429.1 → XP_063118499.1 neurexin-1 isoform X30
XM_063262436.1 → XP_063118506.1 neurexin-1 isoform X38
XM_063262426.1 → XP_063118496.1 neurexin-1 isoform X27
XM_063262428.1 → XP_063118498.1 neurexin-1 isoform X29
XM_063262430.1 → XP_063118500.1 neurexin-1 isoform X31
XM_063262431.1 → XP_063118501.1 neurexin-1 isoform X32
XM_063262437.1 → XP_063118507.1 neurexin-1 isoform X40

Related

ENSRNOP00000066979.5, ENSRNOT00000071402.6
XM_063262434.1 → XP_063118504.1 neurexin-1 isoform X35

Related

ENSRNOP00000100919.1, ENSRNOT00000166638.1
XM_039112842.2 → XP_038968770.1 neurexin-1 isoform X41

UniProtKB/TrEMBL

A0A8I6A146

Conserved Domains (6) summary

smart00294
Location:1385 → 1403

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:475 → 624

LamG; Laminin G domain

cd00054
Location:652 → 685

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:30 → 190

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1365 → 1400

Syndecan; Syndecan domain

pfam02210
Location:896 → 1024

Laminin_G_2; Laminin G domain
XM_039112843.2 → XP_038968771.1 neurexin-1 isoform X42

UniProtKB/TrEMBL

A0A8I6A146

Conserved Domains (6) summary

smart00294
Location:1382 → 1400

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:475 → 624

LamG; Laminin G domain

cd00054
Location:652 → 685

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:30 → 190

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1362 → 1397

Syndecan; Syndecan domain

pfam02210
Location:896 → 1024

Laminin_G_2; Laminin G domain
XM_063262439.1 → XP_063118509.1 neurexin-1 isoform X48
XM_063262438.1 → XP_063118508.1 neurexin-1 isoform X43
XM_039112845.2 → XP_038968773.1 neurexin-1 isoform X44

UniProtKB/Swiss-Prot

Q63373

UniProtKB/TrEMBL

A0A8I5ZTY7, A6H9A7

Related

ENSRNOP00000080874.1, ENSRNOT00000092255.3

Conserved Domains (3) summary

smart00294
Location:413 → 431

4.1m; putative band 4.1 homologues' binding motif

cd00110
Location:86 → 205

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:393 → 428

Syndecan; Syndecan domain
XM_039112846.2 → XP_038968774.1 neurexin-1 isoform X45

UniProtKB/Swiss-Prot

Q63373

Conserved Domains (3) summary

smart00294
Location:410 → 428

4.1m; putative band 4.1 homologues' binding motif

cd00110
Location:86 → 205

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:390 → 425

Syndecan; Syndecan domain
XM_039112847.2 → XP_038968775.1 neurexin-1 isoform X46

UniProtKB/Swiss-Prot

Q63373

Conserved Domains (3) summary

smart00294
Location:383 → 401

4.1m; putative band 4.1 homologues' binding motif

cd00110
Location:86 → 234

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:363 → 398

Syndecan; Syndecan domain
XM_039112849.2 → XP_038968777.1 neurexin-1 isoform X47

UniProtKB/Swiss-Prot

Q63373

Conserved Domains (3) summary

smart00294
Location:380 → 398

4.1m; putative band 4.1 homologues' binding motif

cd00110
Location:86 → 234

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:360 → 395

Syndecan; Syndecan domain
XM_039112864.2 → XP_038968792.1 neurexin-1 isoform X49

Related

ENSRNOP00000111244.1, ENSRNOT00000140337.1

Conserved Domains (2) summary

smart00294
Location:87 → 105

4.1m; putative band 4.1 homologues' binding motif

pfam01034
Location:67 → 102

Syndecan; Syndecan domain
XM_039112865.2 → XP_038968793.1 neurexin-1 isoform X50

UniProtKB/TrEMBL

A0A8I5ZU71

Conserved Domains (2) summary

smart00294
Location:84 → 102

4.1m; putative band 4.1 homologues' binding motif

pfam01034
Location:64 → 99

Syndecan; Syndecan domain