hmgxb4 HMG box domain containing 4 [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: hmgxb4provided by Xenbase
Official Full Name: HMG box domain containing 4provided by Xenbase
Primary source: Xenbase:XB-GENE-951781
See related: Ensembl:ENSXETG00000006340 AllianceGenome:Xenbase:XB-GENE-951781
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as: hmg2l1; hmgbcg; hmgb2l1; xHMG2L1; thc211630
Summary: Predicted to enable protein kinase binding activity. Predicted to act upstream of or within negative regulation of Wnt signaling pathway. Predicted to be located in nucleus. Orthologous to human HMGXB4 (HMG-box containing 4). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	4	NC_030680.2 (122053427..122063536, complement)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	4	NC_030680.1 (111659905..111670386, complement)

Chromosome 4 - NC_030680.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: HMG box-containing protein 4

Names: high-mobility group protein 2-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001030384.1 → NP_001025555.1 HMG box-containing protein 4

See identical proteins and their annotated locations for NP_001025555.1

Status: PROVISIONAL

Source sequence(s)

BC090595

UniProtKB/Swiss-Prot

Q5BL56

Related

ENSXETP00000013886.5, ENSXETT00000013886.5

Conserved Domains (2) summary

cd00084
Location:364 → 423

HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

pfam13775
Location:107 → 226

DUF4171; Domain of unknown function (DUF4171)

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

NC_030680.2 Reference UCB_Xtro_10.0 Primary Assembly

Range

122053427..122063536 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_012961211.3 → XP_012816665.2 HMG box-containing protein 4 isoform X1

Conserved Domains (2) summary

cd00084
Location:364 → 423

HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

pfam13775
Location:107 → 226

DUF4171; Domain of unknown function (DUF4171)
XM_012961213.3 → XP_012816667.2 HMG box-containing protein 4 isoform X2

UniProtKB/TrEMBL

A0A803JL94

Related

ENSXETP00000108737.1, ENSXETT00000105899.1

Conserved Domains (2) summary

cd00084
Location:362 → 421

HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

pfam13775
Location:105 → 224

DUF4171; Domain of unknown function (DUF4171)