HAS2-AS1 HAS2 antisense RNA 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: HAS2-AS1provided by HGNC
Official Full Name: HAS2 antisense RNA 1provided by HGNC
Primary source: HGNC:HGNC:34340
See related: MIM:614353; AllianceGenome:HGNC:34340
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HASNT; HAS2AS; HAS2-AS; NCRNA00077
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 8q24.13

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	8	NC_000008.11 (121639346..121645325)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	8	NC_060932.1 (122769581..122775558)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	8	NC_000008.10 (122651586..122657565)

Chromosome 8 - NC_000008.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Upregulation of HAS2-AS1 Relates to the Granulosa Cell Dysfunction by Repressing TGF-beta Signaling and Upregulating HAS2.
Title: The Upregulation of HAS2-AS1 Relates to the Granulosa Cell Dysfunction by Repressing TGF-β Signaling and Upregulating HAS2.
The natural antisense transcript HAS2-AS1 regulates breast cancer cells aggressiveness independently from hyaluronan metabolism.
Title: The natural antisense transcript HAS2-AS1 regulates breast cancer cells aggressiveness independently from hyaluronan metabolism.
Long noncoding RNA HAS2-AS1 promotes tumor progression in glioblastoma via functioning as a competing endogenous RNA.
Title: Long noncoding RNA HAS2-AS1 promotes tumor progression in glioblastoma via functioning as a competing endogenous RNA.
Sirtuin 1 reduces hyaluronan synthase 2 expression by inhibiting nuclear translocation of NF-kappaB and expression of the long-noncoding RNA HAS2-AS1.
Title: Sirtuin 1 reduces hyaluronan synthase 2 expression by inhibiting nuclear translocation of NF-κB and expression of the long-noncoding RNA HAS2-AS1.
Results provide evidence that Has2-AS has a key role in TGFbeta- and HAS2-induced breast cancer epithelial-mesenchymal transition, migration and acquisition of stemness. Its expression is inversely correlated with survival of patients with invasive breast carcinomas.
Title: Has2 natural antisense RNA and Hmga2 promote Has2 expression during TGFβ-induced EMT in breast cancer.
Hyaluronan synthase 2 (HAS2) antisense RNA 1 (HAS2-AS1) shows low expression in immature cumulus cells (CCs) and a significant increase expression in mature CCs. Functional studies reveal that inhibition of HAS2-AS1 by siRNA causes decreased expression of HAS2. Inhibition of HAS2-AS1 by siRNA results in decreased migration of granulosa cells.
Title: HAS2-AS1 is a novel LH/hCG target gene regulating HAS2 expression and enhancing cumulus cells migration.
Results suggest that hypoxia would induce an overexpression of HAS2-AS1 in an HIF-1alpha dependent manner. The increase of HAS2-AS1 plays important roles mediating the hypoxia-regulated EMT and invasiveness of oral squamous cell carcinoma.
Title: Long noncoding RNA HAS2-AS1 mediates hypoxia-induced invasiveness of oral squamous cell carcinoma.
HAS2 transcription can be finely regulated not only by recruiting transcription factors to the promoter as previously described but also by modulating chromatin accessibility by epigenetic modifications
Title: Natural antisense transcript for hyaluronan synthase 2 (HAS2-AS1) induces transcription of HAS2 via protein O-GlcNAcylation.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

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General gene information

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Other Names

HAS2 antisense RNA 1 (non-protein coding)
hyaluronan synthase 2 antisense

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.