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Slc4a8 solute carrier family 4 (anion exchanger), member 8 [ Mus musculus (house mouse) ]

Gene ID: 59033, updated on 18-Sep-2024

Summary

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Official Symbol
Slc4a8provided by MGI
Official Full Name
solute carrier family 4 (anion exchanger), member 8provided by MGI
Primary source
MGI:MGI:1928745
See related
Ensembl:ENSMUSG00000023032 AllianceGenome:MGI:1928745
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NDCBE; kNBC-3; C230026C11
Summary
Predicted to enable chloride transmembrane transporter activity and sodium:bicarbonate symporter activity. Acts upstream of or within positive regulation of synaptic vesicle exocytosis and regulation of intracellular pH. Located in several cellular components, including glutamatergic synapse; neuronal cell body membrane; and presynaptic membrane. Is expressed in several structures, including adrenal gland; alimentary system; genitourinary system; nervous system; and sensory organ. Orthologous to human SLC4A8 (solute carrier family 4 member 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in frontal lobe adult (RPKM 7.6), cortex adult (RPKM 7.4) and 19 other tissues See more
Orthologs
human all
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Genomic context

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See Slc4a8 in Genome Data Viewer
Location:
15 F1; 15 56.39 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (100659628..100721852)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (100761747..100823971)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10882 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 6, opposite strand Neighboring gene polypeptide N-acetylgalactosaminyltransferase 6 Neighboring gene RIKEN cDNA I730030J21 gene Neighboring gene STARR-positive B cell enhancer ABC_E5518 Neighboring gene STARR-positive B cell enhancer ABC_E2451 Neighboring gene STARR-seq mESC enhancer starr_39762 Neighboring gene predicted gene, 52175 Neighboring gene STARR-seq mESC enhancer starr_39763 Neighboring gene predicted gene, 41401 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:100675553-100676012 Neighboring gene predicted gene, 35569 Neighboring gene sodium channel, voltage-gated, type VIII, alpha Neighboring gene predicted gene, 52176

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Effects of chronic continuous hypoxia on the expression of SLC4A8 (NDCBE) in neonatal versus adult mouse brain. Chen LM, et al. Brain Res, 2008 Oct 31. PMID 18775686, Free PMC Article
  2. Mouse Na+: HCO3- cotransporter isoform NBC-3 (kNBC-3): cloning, expression, and renal distribution. Wang Z, et al. Kidney Int, 2001 Apr. PMID 11260402
  3. Slc4a8 in the Kidney: Expression, Subcellular Localization and Role in Salt Reabsorption. Xu J, et al. Cell Physiol Biochem, 2018. PMID 30355950
  4. K(+)-Driven Cl(-)/HCO(3)(-) Exchange Mediated by Slc4a8 and Slc4a10. Peña-Münzenmayer G, et al. Int J Mol Sci, 2024 Apr 22. PMID 38674160, Free PMC Article
  5. Synaptic glutamate release is modulated by the Na+ -driven Cl-/HCO₃⁻ exchanger Slc4a8. Sinning A, et al. J Neurosci, 2011 May 18. PMID 21593314, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. K[+]-Driven Cl[-]/HCO3[-] Exchange Mediated by Slc4a8 and Slc4a10.
    Title: K(+)-Driven Cl(-)/HCO(3)(-) Exchange Mediated by Slc4a8 and Slc4a10.
  2. Slc4a8 localizes to presynaptic nerve endings and modulates glutamate release in a pH-dependent manner.
    Title: Synaptic glutamate release is modulated by the Na+ -driven Cl-/HCO₃⁻ exchanger Slc4a8.
  3. SLC4A8 mediates an electroneutral Na+ reabsorption process in the renal cortical collecting ducts of mice
    Title: The Na+-dependent chloride-bicarbonate exchanger SLC4A8 mediates an electroneutral Na+ reabsorption process in the renal cortical collecting ducts of mice.
  4. mouse brain exhibits marked developmental differences in the response of NDCBE protein expression to chronic continuous hypoxia
    Title: Effects of chronic continuous hypoxia on the expression of SLC4A8 (NDCBE) in neonatal versus adult mouse brain.
  5. Thus, SLC4A8 is in a position to contribute substantially to pH(i) regulation in multiple CNS neurons.
    Title: Expression and localization of Na-driven Cl-HCO(3)(-) exchanger (SLC4A8) in rodent CNS.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables bicarbonate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables chloride transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables sodium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables sodium,bicarbonate:chloride antiporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sodium,bicarbonate:chloride antiporter activity ISO
Inferred from Sequence Orthology
more info
  
enables sodium:bicarbonate symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sodium:bicarbonate symporter activity IEA
Inferred from Electronic Annotation
more info
  
enables sodium:bicarbonate symporter activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in basolateral protein secretion IEA
Inferred from Electronic Annotation
more info
  
involved_in basolateral protein secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in bicarbonate transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in bicarbonate transport IEA
Inferred from Electronic Annotation
more info
  
involved_in bicarbonate transport ISO
Inferred from Sequence Orthology
more info
  
involved_in chloride transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in chloride transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within embryo development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of synaptic vesicle exocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of intracellular pH IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of intracellular pH IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of intracellular pH ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of intracellular pH ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of membrane potential IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of synaptic vesicle exocytosis EXP
Inferred from Experiment
more info
 PubMed 
involved_in regulation of synaptic vesicle exocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of synaptic vesicle exocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sodium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in asymmetric synapse IEA
Inferred from Electronic Annotation
more info
  
located_in asymmetric synapse ISO
Inferred from Sequence Orthology
more info
  
located_in axon terminus ISO
Inferred from Sequence Orthology
more info
  
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in glial cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in glial cell projection ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in hippocampal mossy fiber IEA
Inferred from Electronic Annotation
more info
  
located_in hippocampal mossy fiber ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in presynapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in presynapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in presynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynaptic membrane IEP
Inferred from Expression Pattern
more info
 PubMed 
located_in symmetric synapse IEA
Inferred from Electronic Annotation
more info
  
located_in symmetric synapse ISO
Inferred from Sequence Orthology
more info
  
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in synaptic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
  
located_in terminal bouton IEA
Inferred from Electronic Annotation
more info
  
located_in terminal bouton ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
electroneutral sodium bicarbonate exchanger 1
Names
electroneutral Na+-driven Cl-HCO3 exchanger
k-NBC3
solute carrier family 4 member 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347102.1 → NP_001334031.1  electroneutral sodium bicarbonate exchanger 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC113587, AK141910, AK171610, BP759706
    Consensus CDS
    CCDS84193.1
    UniProtKB/Swiss-Prot
    Q8JZR6
    UniProtKB/TrEMBL
    Q3UR07
    Related
    ENSMUSP00000125090.2, ENSMUST00000162049.2
    Conserved Domains (1) summary
    cl26877
    Location:65 → 951
    Band_3_cyto; Band 3 cytoplasmic domain

  2. NM_021530.2 → NP_067505.2  electroneutral sodium bicarbonate exchanger 1 isoform 1

    See identical proteins and their annotated locations for NP_067505.2

    Status: VALIDATED

    Source sequence(s)
    AC113587, AK173014, BB626223, BB851903, BP759706
    Consensus CDS
    CCDS37214.1
    UniProtKB/Swiss-Prot
    Q3TAV7, Q6A004, Q8BYI7, Q8JZR6, Q9JKV6
    Related
    ENSMUSP00000023776.7, ENSMUST00000023776.13
    Conserved Domains (3) summary
    TIGR00834
    Location:117 → 1003
    ae; anion exchange protein
    pfam00955
    Location:443 → 956
    HCO3_cotransp; HCO3- transporter family
    pfam07565
    Location:145 → 402
    Band_3_cyto; Band 3 cytoplasmic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    100659628..100721852
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017316718.2 → XP_017172207.1  electroneutral sodium bicarbonate exchanger 1 isoform X1

    UniProtKB/Swiss-Prot
    Q8JZR6
    Conserved Domains (1) summary
    cl26877
    Location:65 → 951
    Band_3_cyto; Band 3 cytoplasmic domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001033218.1: Suppressed sequence

    Description
    NM_001033218.1: This RefSeq was permanently suppressed because it is primarily UTR sequence.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8JZR6.1 GenPept UniProtKB/Swiss-Prot:Q8JZR6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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