RAD23B RAD23 homolog B, nucleotide excision repair protein [Homo sapiens (human)] - Gene

Summary

Official Symbol: RAD23Bprovided by HGNC
Official Full Name: RAD23 homolog B, nucleotide excision repair proteinprovided by HGNC
Primary source: HGNC:HGNC:9813
See related: Ensembl:ENSG00000119318 MIM:600062; AllianceGenome:HGNC:9813
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: P58; HR23B; HHR23B
Summary: The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in the nucleotide excision repair (NER). This protein was found to be a component of the protein complex that specifically complements the NER defect of xeroderma pigmentosum group C (XP-c) cell extracts in vitro. This protein was also shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, and thus this protein may be involved in the ubiquitin mediated proteolytic pathway in cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2011]
Expression: Ubiquitous expression in liver (RPKM 44.7), fat (RPKM 43.3) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 9q31.2

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	9	NC_000009.12 (107283279..107332194)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	9	NC_060933.1 (119455054..119503938)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	9	NC_000009.11 (110045560..110094475)

Chromosome 9 - NC_000009.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HDAC6 Inhibition Releases HR23B to Activate Proteasomes, Expand the Tumor Immunopeptidome and Amplify T-cell Antimyeloma Activity.
Title: HDAC6 Inhibition Releases HR23B to Activate Proteasomes, Expand the Tumor Immunopeptidome and Amplify T-cell Antimyeloma Activity.
Knockdown of circRAD23B Exerts Antitumor Response in Colorectal Cancer via the Regulation of miR-1205/TRIM44 axis.
Title: Knockdown of circRAD23B Exerts Antitumor Response in Colorectal Cancer via the Regulation of miR-1205/TRIM44 axis.
Deubiquitinase PSMD7 promotes the proliferation, invasion, and cisplatin resistance of gastric cancer cells by stabilizing RAD23B.
Title: Deubiquitinase PSMD7 promotes the proliferation, invasion, and cisplatin resistance of gastric cancer cells by stabilizing RAD23B.
Cytoplasmic RAD23B interacts with CORO1C to synergistically promote colorectal cancer progression and metastasis.
Title: Cytoplasmic RAD23B interacts with CORO1C to synergistically promote colorectal cancer progression and metastasis.
Upregulation of GRIM-19 augments the sensitivity of prostate cancer cells to docetaxel by targeting Rad23b.
Title: Upregulation of GRIM-19 augments the sensitivity of prostate cancer cells to docetaxel by targeting Rad23b.
Histone H4K20 Demethylation by Two hHR23 Proteins.
Title: Histone H4K20 Demethylation by Two hHR23 Proteins.
Functional impacts of the ubiquitin-proteasome system on DNA damage recognition in global genome nucleotide excision repair.
Title: Functional impacts of the ubiquitin-proteasome system on DNA damage recognition in global genome nucleotide excision repair.
Inhibition of Excision of Oxidatively Generated Hydantoin DNA Lesions by NEIL1 by the Competitive Binding of the Nucleotide Excision Repair Factor XPC-RAD23B.
Title: Inhibition of Excision of Oxidatively Generated Hydantoin DNA Lesions by NEIL1 by the Competitive Binding of the Nucleotide Excision Repair Factor XPC-RAD23B.
Study reports RAD23B copy number variation in 10% (12/119, P </= 0.01) of Sezary syndrome (SS) patients, associated with reduced mRNA expression. RAD23B knockdown in a cutaneous T-cell lymphoma cell line led to a reduction in FK228-induced apoptosis. Findings suggest that RAD23B gene perturbations could reduce sensitivity to histone deacetylase inhibitors in SS patients.
Title: Contribution of STAT3 and RAD23B in Primary Sézary Cells to Histone Deacetylase Inhibitor FK228 Resistance.
TYMS was absent in 100% of circulating tumor cells (CTCs) from locally advanced rectal cancer patients with pathologic complete response yet was expressed in 83% of non-responders prior to surgery (S2). RAD23B was expressed in CTCs from 75% of non-responders prior to neoadjuvant chemoradiation (S1) and in 100% of non-responders at S2. 100% of non-responders expressed TYMS mRNA at both timepoints.
Title: Molecular and Kinetic Analyses of Circulating Tumor Cells as Predictive Markers of Treatment Response in Locally Advanced Rectal Cancer Patients.

Submit: New GeneRIF Correction See all GeneRIFs (46)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study in Chinese men identifies two new prostate cancer risk loci at 9q31.2 and 19q13.4. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women. EBI GWAS Catalog EBI GWAS CatalogPubMed
Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Screening in Jurkat T-cells with a short-hairpin-RNA (shRNA) library identifies RAD23 homolog B (RAD23B) is important for HIV-1 replication	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

A006X46 (e-PCR)
- UniSTS:56584

D8S2279 (e-PCR)
- UniSTS:473907

G67269 (e-PCR)
- UniSTS:186463

G67265 (e-PCR)
- UniSTS:186464

G67266 (e-PCR)
- UniSTS:186465

G67267 (e-PCR)
- UniSTS:186466

G67268 (e-PCR)
- UniSTS:186467

RAD23B_1857 (e-PCR)
- UniSTS:280954

SGC32118 (e-PCR)
- UniSTS:70804

STS-T93562 (e-PCR)
- UniSTS:24472

D9S2006 (e-PCR)
- UniSTS:37347

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA damage sensor activity	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	IEA Inferred from Electronic Annotation more info
enables damaged DNA binding	IEA Inferred from Electronic Annotation more info
enables polyubiquitin modification-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables polyubiquitin modification-dependent protein binding	IDA Inferred from Direct Assay more info	PubMed
enables proteasome binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables single-stranded DNA binding	TAS Traceable Author Statement more info	PubMed
enables ubiquitin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cellular response to interleukin-7	IEA Inferred from Electronic Annotation more info
involved_in nucleotide-excision repair	IDA Inferred from Direct Assay more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of XPC complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	TAS Traceable Author Statement more info	PubMed
part_of proteasome complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: UV excision repair protein RAD23 homolog B

Names: RAD23, yeast homolog of, B; XP-C repair complementing complex 58 kDa; XP-C repair complementing protein; XP-C repair-complementing complex 58 kDa protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001244713.1 → NP_001231642.1 UV excision repair protein RAD23 homolog B isoform 2

See identical proteins and their annotated locations for NP_001231642.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) has a distinct 5' UTR and 5' CDS, compared to isoform (1), which results in an isoform (2) with a shorter and distinct N-terminus, compared to isoform 1.

Source sequence(s)

AI375313, AK297986, AL137852, BI460482

UniProtKB/TrEMBL

B7Z4W4, B7ZA74

Conserved Domains (1) summary

TIGR00601
Location:2 → 386

rad23; UV excision repair protein Rad23
NM_001244724.2 → NP_001231653.1 UV excision repair protein RAD23 homolog B isoform 3

See identical proteins and their annotated locations for NP_001231653.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to isoform (1). The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AK297986, AL137852, AY313777

Consensus CDS

CCDS59138.1

UniProtKB/TrEMBL

B7ZA74

Related

ENSP00000405623.2, ENST00000416373.6

Conserved Domains (1) summary

TIGR00601
Location:1 → 335

rad23; UV excision repair protein Rad23
NM_002874.5 → NP_002865.1 UV excision repair protein RAD23 homolog B isoform 1

See identical proteins and their annotated locations for NP_002865.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AL137852, D21090, DC404422

Consensus CDS

CCDS6769.1

UniProtKB/Swiss-Prot

B3KWK8, G5E9P0, P54727, Q7Z5K8, Q8WUB0

UniProtKB/TrEMBL

Q53F10

Related

ENSP00000350708.3, ENST00000358015.8

Conserved Domains (1) summary

TIGR00601
Location:1 → 407

rad23; UV excision repair protein Rad23