PTPRZ1 protein tyrosine phosphatase receptor type Z1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PTPRZ1provided by HGNC
Official Full Name: protein tyrosine phosphatase receptor type Z1provided by HGNC
Primary source: HGNC:HGNC:9685
See related: Ensembl:ENSG00000106278 MIM:176891; AllianceGenome:HGNC:9685
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PTPZ; HPTPZ; PTP18; PTPRZ; RPTPB; HPTPzeta; PTP-ZETA; RPTPbeta; phosphacan; R-PTP-zeta-2
Summary: This gene encodes a member of the receptor protein tyrosine phosphatase family. Expression of this gene is restricted to the central nervous system (CNS), and it may be involved in the regulation of specific developmental processes in the CNS. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]
Expression: Biased expression in brain (RPKM 103.2) and skin (RPKM 10.8) See more
Orthologs: mouse all
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Genomic context

Location:: 7q31.32

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (121873161..122062036)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (123189006..123377936)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (121513215..121702090)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The PTPRZ1-MET/STAT3/ISG20 axis in glioma stem-like cells modulates tumor-associated macrophage polarization.
Title: The PTPRZ1-MET/STAT3/ISG20 axis in glioma stem-like cells modulates tumor-associated macrophage polarization.
Brain-specific glycosylation enzyme GnT-IX maintains levels of protein tyrosine phosphatase receptor PTPRZ, thereby mediating glioma growth.
Title: Brain-specific glycosylation enzyme GnT-IX maintains levels of protein tyrosine phosphatase receptor PTPRZ, thereby mediating glioma growth.
The Glycoprotein M6a Is Associated with Invasiveness and Radioresistance of Glioblastoma Stem Cells.
Title: The Glycoprotein M6a Is Associated with Invasiveness and Radioresistance of Glioblastoma Stem Cells.
Protein Tyrosine Phosphatase Receptor Type Z in Central Nervous System Disease.
Title: Protein Tyrosine Phosphatase Receptor Type Z in Central Nervous System Disease.
High-sensitive clinical diagnostic method for PTPRZ1-MET and the characteristic protein structure contributing to ligand-independent MET activation.
Title: High-sensitive clinical diagnostic method for PTPRZ1-MET and the characteristic protein structure contributing to ligand-independent MET activation.
A novel PTPRZ1-ETV1 fusion in gliomas.
Title: A novel PTPRZ1-ETV1 fusion in gliomas.
Expression of circ-PTPRZ1/PAK1 is regulated by miR-1261, which affects the proliferation, apoptosis, and invasion of glioma cells.
Title: MiR-1261/circ-PTPRZ1/PAK1 pathway regulates glioma cell growth and invasion.
The data reveal that CDK5 is activated by PTN, in an RPTPbeta-zeta-dependent manner, regulates PTN-induced cell migration and is an attractive target for the inhibition of PTN pro-angiogenic properties.
Title: Cyclin-dependent kinase 5 mediates pleiotrophin-induced endothelial cell migration.
the mechanism of chemoresistance by chemotherapy-driven increases in the CDKN1A/PTN/PTPRZ1 axis depended on the NF-kappaB pathway
Title: Chemotherapy-driven increases in the CDKN1A/PTN/PTPRZ1 axis promote chemoresistance by activating the NF-κB pathway in breast cancer cells.
High PTPRZ1 expression is associated with glioblastoma.
Title: Targeting PTPRZ inhibits stem cell-like properties and tumorigenicity in glioblastoma cells.

Submit: New GeneRIF Correction See all GeneRIFs (54)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH122873 (e-PCR)
- UniSTS:135170

RH122881 (e-PCR)
- UniSTS:135178

D7S466 (e-PCR)
- UniSTS:73757

SHGC-30278 (e-PCR)
- UniSTS:71229

SHGC-36248 (e-PCR)
- UniSTS:71769

PTPRZ1_2426 (e-PCR)
- UniSTS:280947

RH47696 (e-PCR)
- UniSTS:8597

PTPRZ (e-PCR)
- UniSTS:39077

D7S2737 (e-PCR)
- UniSTS:77234

D7S601E (e-PCR)
- UniSTS:473072

RH26920 (e-PCR)
- UniSTS:85492

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables histone H2AXY142 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables integrin binding	IDA Inferred from Direct Assay more info	PubMed
enables non-membrane spanning protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein tyrosine phosphatase activity	TAS Traceable Author Statement more info
enables protein tyrosine phosphatase activity, metal-dependent	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine phosphatase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in axonogenesis	IEA Inferred from Electronic Annotation more info
involved_in central nervous system development	TAS Traceable Author Statement more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in hematopoietic progenitor cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in learning or memory	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of neuron apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
involved_in oligodendrocyte differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in oligodendrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in peptidyl-tyrosine dephosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of oligodendrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein dephosphorylation	TAS Traceable Author Statement more info	PubMed
involved_in regulation of myelination	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of oligodendrocyte progenitor proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in perineuronal net	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: receptor-type tyrosine-protein phosphatase zeta

Names: protein tyrosine phosphatase, receptor-type, Z polypeptide 1; protein tyrosine phosphatase, receptor-type, zeta polypeptide 1; protein-tyrosine phosphatase receptor type Z polypeptide 2; receptor-type tyrosine phosphatase beta/zeta

NP_001193767.1

EC 3.1.3.48

NP_001193768.1

EC 3.1.3.48

NP_001356324.1

EC 3.1.3.48

NP_001356325.1

EC 3.1.3.48

NP_002842.2

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_023266.1 RefSeqGene

Range

5057..193932

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_1387

mRNA and Protein(s)

NM_001206838.2 → NP_001193767.1 receptor-type tyrosine-protein phosphatase zeta isoform 2 precursor

See identical proteins and their annotated locations for NP_001193767.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame donor splice site at an internal coding exon compared to variant 1. This results in a shorter isoform (2) missing an internal protein segment compared to isoform 1.

Source sequence(s)

AK294062, DA454064, M93426, U88967

UniProtKB/TrEMBL

A0A494C1H9

Related

ENSP00000499073.1, ENST00000651065.1

Conserved Domains (4) summary

smart00194
Location:856 → 1131

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:892 → 1131

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd03122
Location:45 → 298

alpha_CARP_receptor_like; Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon ...

pfam00041
Location:313 → 401

fn3; Fibronectin type III domain
NM_001206839.2 → NP_001193768.1 receptor-type tyrosine-protein phosphatase zeta isoform 3 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate in-frame donor splice site at an internal coding exon, and is lacking another in-frame coding exon compared to variant 1. This results in a shorter isoform (2) missing two internal protein segments compared to isoform 1.

Source sequence(s)

BC131736, DA454064, M93426, U88967

Consensus CDS

CCDS56505.1

UniProtKB/TrEMBL

A0A494C1R4

Related

ENSP00000410000.1, ENST00000449182.1

Conserved Domains (4) summary

cd00063
Location:313 → 406

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd03122
Location:45 → 298

alpha_CARP_receptor_like; Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon ...

cd17669
Location:1210 → 1413

R-PTP-Z-2; catalytic domain of receptor-type tyrosine-protein phosphatase Z, repeat 2

cl28904
Location:857 → 1127

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
NM_001369395.1 → NP_001356324.1 receptor-type tyrosine-protein phosphatase zeta isoform 4 precursor

Status: REVIEWED

Source sequence(s)

AC006020, AC006353, AC073095

Consensus CDS

CCDS94187.1

UniProtKB/TrEMBL

A0A494C055

Related

ENSP00000499137.1, ENST00000652298.1

Conserved Domains (5) summary

cd03122
Location:45 → 298

alpha_CARP_receptor_like; Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon ...

pfam07263
Location:1450 → 1567

DMP1; Dentin matrix protein 1 (DMP1)

pfam00041
Location:313 → 395

fn3; Fibronectin type III domain

cd17669
Location:2070 → 2273

R-PTP-Z-2; catalytic domain of receptor-type tyrosine-protein phosphatase Z, repeat 2

cl28904
Location:1717 → 1987

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
NM_001369396.1 → NP_001356325.1 receptor-type tyrosine-protein phosphatase zeta isoform 5

Status: REVIEWED

Source sequence(s)

AC006020, AC006353, AC073095

UniProtKB/TrEMBL

A0A494C087

Conserved Domains (5) summary

cd03122
Location:31 → 284

alpha_CARP_receptor_like; Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon ...

pfam07263
Location:1436 → 1553

DMP1; Dentin matrix protein 1 (DMP1)

pfam00041
Location:299 → 381

fn3; Fibronectin type III domain

cd17669
Location:2063 → 2266

R-PTP-Z-2; catalytic domain of receptor-type tyrosine-protein phosphatase Z, repeat 2

cl28904
Location:1703 → 1980

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
NM_002851.3 → NP_002842.2 receptor-type tyrosine-protein phosphatase zeta isoform 1 precursor

See identical proteins and their annotated locations for NP_002842.2

Status: REVIEWED

Source sequence(s)

CX868991, CX872418, DA101746, DA454064, M93426, U88967

Consensus CDS

CCDS34740.1

UniProtKB/Swiss-Prot

A4D0W5, C9JFM0, O76043, P23471, Q9UDR6

UniProtKB/TrEMBL

A0A494C087

Related

ENSP00000377047.2, ENST00000393386.7

Conserved Domains (6) summary

smart00194
Location:1716 → 1991

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:1752 → 1991

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd03122
Location:45 → 298

alpha_CARP_receptor_like; Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon ...

pfam00041
Location:313 → 401

fn3; Fibronectin type III domain

pfam07777
Location:684 → 763

MFMR; G-box binding protein MFMR

pfam17061
Location:1089 → 1255

PARM; PARM