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spon1a spondin 1a [ Danio rerio (zebrafish) ]

Gene ID: 58027, updated on 2-Nov-2024

Summary

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Official Symbol
spon1aprovided by ZNC
Official Full Name
spondin 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-000427-9
See related
Ensembl:ENSDARG00000010029 AllianceGenome:ZFIN:ZDB-GENE-000427-9
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
F-spondin1
Summary
Predicted to enable metal ion binding activity. Predicted to be involved in cell adhesion. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Is expressed in central nervous system; eye; and hypochord. Orthologous to human SPON1 (spondin 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See spon1a in Genome Data Viewer
Location:
chromosome: 18
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (28564640..28880191)
105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (28586400..28901951)

Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene KIAA1549-like b Neighboring gene uncharacterized LOC137488290 Neighboring gene uncharacterized LOC103909143 Neighboring gene uncharacterized LOC137488291 Neighboring gene si:ch211-174j14.2 Neighboring gene synaptotagmin IXa

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. F-spondin/spon1b expression patterns in developing and adult zebrafish. Akle V, et al. PLoS One, 2012. PMID 22768035, Free PMC Article
  2. Expanding allelic and phenotypic spectrum of ZC4H2-related disorder: A novel hypomorphic variant and high prevalence of tethered cord. Wongkittichote P, et al. Clin Genet, 2023 Feb. PMID 36250278
  3. Inhibition of protein kinase A phenocopies ectopic expression of hedgehog in the CNS of wild-type and cyclops mutant embryos. Ungar AR, et al. Dev Biol, 1996 Aug 25. PMID 8812120
  4. Characterization of F-spondin in Japanese flounder (Paralichthys olivaceus) and its role in the nervous system development of teleosts. Hu H, et al. Gene, 2016 Jan 10. PMID 26390814
  5. Regulatory gene expression patterns reveal transverse and longitudinal subdivisions of the embryonic zebrafish forebrain. Hauptmann G, et al. Mech Dev, 2000 Mar 1. PMID 10704836

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
spondin-1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131515.1 → NP_571590.1  spondin-1a precursor

    See identical proteins and their annotated locations for NP_571590.1

    Status: PROVISIONAL

    Source sequence(s)
    AB006086
    UniProtKB/TrEMBL
    O42113
    Related
    ENSDARP00000026964.9, ENSDART00000016983.10
    Conserved Domains (3) summary
    cd08544
    Location:49 → 182
    Reeler; Reeler, the N-terminal domain of reelin, F-spondin, and a variety of other proteins
    pfam00090
    Location:618 → 665
    TSP_1; Thrombospondin type 1 domain
    pfam06468
    Location:205 → 392
    Spond_N; Spondin_N

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007129.7 Reference GRCz11 Primary Assembly

    Range
    28564640..28880191
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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