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ANKRD36B ankyrin repeat domain 36B [ Homo sapiens (human) ]

Gene ID: 57730, updated on 2-Nov-2024

Summary

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Official Symbol
ANKRD36Bprovided by HGNC
Official Full Name
ankyrin repeat domain 36Bprovided by HGNC
Primary source
HGNC:HGNC:29333
See related
Ensembl:ENSG00000196912 AllianceGenome:HGNC:29333
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KIAA1641
Summary
Enables identical protein binding activity. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in bone marrow (RPKM 3.8), testis (RPKM 3.0) and 24 other tissues See more
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Genomic context

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See ANKRD36B in Genome Data Viewer
Location:
2q11.2
Exon count:
48
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (97492663..97589877, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (97950887..98048093, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (98109127..98206340, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene immunoglobulin kappa variable 1/OR2-11 (pseudogene) Neighboring gene uncharacterized LOC107985920 Neighboring gene atherosclerotic plaque pathogenesis associated transcript Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:98206492-98206992 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:98222123-98222979 Neighboring gene uncharacterized LOC105373499 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:98233139-98233656 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:98235127-98236008 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:98238522-98239022 Neighboring gene MPRA-validated peak3795 silencer Neighboring gene UBTF like 6 (pseudogene)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Clone Names

  • FLJ21281, FLJ90089, KIAA1641, MGC149864, MGC149865, MGC167812

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
ankyrin repeat domain-containing protein 36B
Names
CLL-associated antigen KW-1
melanoma-associated antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001353337.2 → NP_001340266.1  ankyrin repeat domain-containing protein 36B isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC017099
    UniProtKB/TrEMBL
    A0A087WX87
    Conserved Domains (2) summary
    cd00204
    Location:24 → 139
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:54 → 83
    ANK; ANK repeat [structural motif]

  2. NM_001393939.1 → NP_001380868.1  ankyrin repeat domain-containing protein 36B isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC017099
    Consensus CDS
    CCDS74543.1
    UniProtKB/Swiss-Prot
    Q08AK5, Q6IPR0, Q6PI49, Q8IZM7, Q8N2N9, Q8TDH6, Q96N30, Q9H759
    Related
    ENSP00000477778.1, ENST00000359901.9
    Conserved Domains (5) summary
    COG0666
    Location:17 → 209
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:54 → 83
    ANK; ANK repeat [structural motif]
    pfam15921
    Location:712 → 1342
    CCDC158; Coiled-coil domain-containing protein 158
    pfam12796
    Location:24 → 116
    Ank_2; Ankyrin repeats (3 copies)
    pfam14915
    Location:949 → 1240
    CCDC144C; CCDC144C protein coiled-coil region

  3. NM_025190.4 → NP_079466.3  ankyrin repeat domain-containing protein 36B isoform 1

    See identical proteins and their annotated locations for NP_079466.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC017099
    Consensus CDS
    CCDS74543.1
    UniProtKB/Swiss-Prot
    Q08AK5, Q6IPR0, Q6PI49, Q8IZM7, Q8N2N9, Q8TDH6, Q96N30, Q9H759
    Related
    ENSP00000481149.1, ENST00000258459.12
    Conserved Domains (5) summary
    COG0666
    Location:17 → 209
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:54 → 83
    ANK; ANK repeat [structural motif]
    pfam15921
    Location:712 → 1342
    CCDC158; Coiled-coil domain-containing protein 158
    pfam12796
    Location:24 → 116
    Ank_2; Ankyrin repeats (3 copies)
    pfam14915
    Location:949 → 1240
    CCDC144C; CCDC144C protein coiled-coil region

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    97492663..97589877 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047445328.1 → XP_047301284.1  ankyrin repeat domain-containing protein 36B isoform X7

  2. XM_047445323.1 → XP_047301279.1  ankyrin repeat domain-containing protein 36B isoform X4

  3. XM_047445324.1 → XP_047301280.1  ankyrin repeat domain-containing protein 36B isoform X5

  4. XM_047445330.1 → XP_047301286.1  ankyrin repeat domain-containing protein 36B isoform X9

  5. XM_047445329.1 → XP_047301285.1  ankyrin repeat domain-containing protein 36B isoform X8

  6. XM_047445327.1 → XP_047301283.1  ankyrin repeat domain-containing protein 36B isoform X6

  7. XM_047445321.1 → XP_047301277.1  ankyrin repeat domain-containing protein 36B isoform X3

  8. XM_017004578.3 → XP_016860067.1  ankyrin repeat domain-containing protein 36B isoform X2

    Conserved Domains (3) summary
    sd00045
    Location:54 → 83
    ANK; ANK repeat [structural motif]
    pfam15921
    Location:712 → 1341
    CCDC158; Coiled-coil domain-containing protein 158
    cl39094
    Location:11 → 211
    Ank_2; Ankyrin repeats (3 copies)

  9. XM_005263995.6 → XP_005264052.1  ankyrin repeat domain-containing protein 36B isoform X1

    See identical proteins and their annotated locations for XP_005264052.1

    UniProtKB/Swiss-Prot
    Q08AK5, Q6IPR0, Q6PI49, Q8IZM7, Q8N2N9, Q8TDH6, Q96N30, Q9H759
    Conserved Domains (5) summary
    COG0666
    Location:17 → 209
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:54 → 83
    ANK; ANK repeat [structural motif]
    pfam15921
    Location:712 → 1342
    CCDC158; Coiled-coil domain-containing protein 158
    pfam12796
    Location:24 → 116
    Ank_2; Ankyrin repeats (3 copies)
    pfam14915
    Location:949 → 1240
    CCDC144C; CCDC144C protein coiled-coil region

  10. XM_047445336.1 → XP_047301292.1  ankyrin repeat domain-containing protein 36B isoform X13

  11. XM_047445331.1 → XP_047301287.1  ankyrin repeat domain-containing protein 36B isoform X10

  12. XM_047445335.1 → XP_047301291.1  ankyrin repeat domain-containing protein 36B isoform X12

  13. XM_047445334.1 → XP_047301290.1  ankyrin repeat domain-containing protein 36B isoform X11

  14. XM_047445337.1 → XP_047301293.1  ankyrin repeat domain-containing protein 36B isoform X14

  15. XM_047445342.1 → XP_047301298.1  ankyrin repeat domain-containing protein 36B isoform X22

  16. XM_047445338.1 → XP_047301294.1  ankyrin repeat domain-containing protein 36B isoform X15

  17. XM_047445341.1 → XP_047301297.1  ankyrin repeat domain-containing protein 36B isoform X21

  18. XM_047445339.1 → XP_047301295.1  ankyrin repeat domain-containing protein 36B isoform X19

  19. XM_047445340.1 → XP_047301296.1  ankyrin repeat domain-containing protein 36B isoform X20

  20. XM_011511558.3 → XP_011509860.1  ankyrin repeat domain-containing protein 36B isoform X18

    Conserved Domains (4) summary
    cd00204
    Location:47 → 172
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:24 → 116
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:171 → 225
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:54 → 83
    ANK; ANK repeat [structural motif]

  21. XM_011511556.3 → XP_011509858.1  ankyrin repeat domain-containing protein 36B isoform X16

    See identical proteins and their annotated locations for XP_011509858.1

    Conserved Domains (4) summary
    cd00204
    Location:47 → 172
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:24 → 116
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:171 → 225
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:54 → 83
    ANK; ANK repeat [structural motif]

  22. XM_011511555.3 → XP_011509857.1  ankyrin repeat domain-containing protein 36B isoform X16

    See identical proteins and their annotated locations for XP_011509857.1

    Conserved Domains (4) summary
    cd00204
    Location:47 → 172
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:24 → 116
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:171 → 225
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:54 → 83
    ANK; ANK repeat [structural motif]

  23. XM_011511557.4 → XP_011509859.1  ankyrin repeat domain-containing protein 36B isoform X17

    Conserved Domains (4) summary
    cd00204
    Location:47 → 172
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:24 → 116
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:171 → 225
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:54 → 83
    ANK; ANK repeat [structural motif]

RNA

  1. XR_007078917.1 RNA Sequence

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791765.1 Reference GRCh38.p14 PATCHES

    Range
    418694..515908 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054332972.1 → XP_054188947.1  ankyrin repeat domain-containing protein 36B isoform X7

  2. XM_054332969.1 → XP_054188944.1  ankyrin repeat domain-containing protein 36B isoform X4

  3. XM_054332970.1 → XP_054188945.1  ankyrin repeat domain-containing protein 36B isoform X5

  4. XM_054332974.1 → XP_054188949.1  ankyrin repeat domain-containing protein 36B isoform X9

  5. XM_054332973.1 → XP_054188948.1  ankyrin repeat domain-containing protein 36B isoform X8

  6. XM_054332971.1 → XP_054188946.1  ankyrin repeat domain-containing protein 36B isoform X6

  7. XM_054332968.1 → XP_054188943.1  ankyrin repeat domain-containing protein 36B isoform X3

  8. XM_054332967.1 → XP_054188942.1  ankyrin repeat domain-containing protein 36B isoform X2

  9. XM_054332966.1 → XP_054188941.1  ankyrin repeat domain-containing protein 36B isoform X1

    UniProtKB/Swiss-Prot
    Q08AK5, Q6IPR0, Q6PI49, Q8IZM7, Q8N2N9, Q8TDH6, Q96N30, Q9H759

  10. XM_054332978.1 → XP_054188953.1  ankyrin repeat domain-containing protein 36B isoform X13

  11. XM_054332975.1 → XP_054188950.1  ankyrin repeat domain-containing protein 36B isoform X10

  12. XM_054332977.1 → XP_054188952.1  ankyrin repeat domain-containing protein 36B isoform X12

  13. XM_054332976.1 → XP_054188951.1  ankyrin repeat domain-containing protein 36B isoform X11

  14. XM_054332979.1 → XP_054188954.1  ankyrin repeat domain-containing protein 36B isoform X14

  15. XM_054332988.1 → XP_054188963.1  ankyrin repeat domain-containing protein 36B isoform X22

  16. XM_054332980.1 → XP_054188955.1  ankyrin repeat domain-containing protein 36B isoform X15

  17. XM_054332987.1 → XP_054188962.1  ankyrin repeat domain-containing protein 36B isoform X21

  18. XM_054332985.1 → XP_054188960.1  ankyrin repeat domain-containing protein 36B isoform X19

  19. XM_054332986.1 → XP_054188961.1  ankyrin repeat domain-containing protein 36B isoform X20

  20. XM_054332984.1 → XP_054188959.1  ankyrin repeat domain-containing protein 36B isoform X18

  21. XM_054332982.1 → XP_054188957.1  ankyrin repeat domain-containing protein 36B isoform X16

  22. XM_054332981.1 → XP_054188956.1  ankyrin repeat domain-containing protein 36B isoform X16

  23. XM_054332983.1 → XP_054188958.1  ankyrin repeat domain-containing protein 36B isoform X17

RNA

  1. XR_008485810.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    97950887..98048093 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054343225.1 → XP_054199200.1  ankyrin repeat domain-containing protein 36B isoform X1

    UniProtKB/Swiss-Prot
    Q08AK5, Q6IPR0, Q6PI49, Q8IZM7, Q8N2N9, Q8TDH6, Q96N30, Q9H759

  2. XM_054343226.1 → XP_054199201.1  ankyrin repeat domain-containing protein 36B isoform X3

  3. XM_054343227.1 → XP_054199202.1  ankyrin repeat domain-containing protein 36B isoform X23

  4. XM_054343228.1 → XP_054199203.1  ankyrin repeat domain-containing protein 36B isoform X24

  5. XM_054343235.1 → XP_054199210.1  ankyrin repeat domain-containing protein 36B isoform X19

  6. XM_054343236.1 → XP_054199211.1  ankyrin repeat domain-containing protein 36B isoform X20

  7. XM_054343232.1 → XP_054199207.1  ankyrin repeat domain-containing protein 36B isoform X18

  8. XM_054343230.1 → XP_054199205.1  ankyrin repeat domain-containing protein 36B isoform X16

  9. XM_054343229.1 → XP_054199204.1  ankyrin repeat domain-containing protein 36B isoform X16

  10. XM_054343234.1 → XP_054199209.1  ankyrin repeat domain-containing protein 36B isoform X26

  11. XM_054343233.1 → XP_054199208.1  ankyrin repeat domain-containing protein 36B isoform X25

  12. XM_054343231.1 → XP_054199206.1  ankyrin repeat domain-containing protein 36B isoform X17

  13. XM_054343237.1 → XP_054199212.1  ankyrin repeat domain-containing protein 36B isoform X27

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_020970.1: Suppressed sequence

    Description
    NM_020970.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N2N9.4 GenPept UniProtKB/Swiss-Prot:Q8N2N9

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