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ARHGAP23 Rho GTPase activating protein 23 [ Homo sapiens (human) ]

Gene ID: 57636, updated on 3-Nov-2024

Summary

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Official Symbol
ARHGAP23provided by HGNC
Official Full Name
Rho GTPase activating protein 23provided by HGNC
Primary source
HGNC:HGNC:29293
See related
Ensembl:ENSG00000275832 MIM:610590; AllianceGenome:HGNC:29293
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The RHO (see ARHA; MIM 165390) family of small GTPases are involved in signal transduction through transmembrane receptors, and they are inactive in the GDP-bound form and active in the GTP-bound form. GTPase-activating proteins, such as ARHGAP23, inactivate RHO family proteins by stimulating their hydrolysis of GTP (Katoh and Katoh, 2004 [PubMed 15254754]).[supplied by OMIM, Mar 2008]
Expression
Broad expression in skin (RPKM 13.7), brain (RPKM 13.2) and 22 other tissues See more
Orthologs
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Genomic context

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See ARHGAP23 in Genome Data Viewer
Location:
17q12
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (38419275..38512385)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (39282325..39375417)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (36584708..36668621)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903991 Neighboring gene suppressor of cytokine signaling 7 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36570079-36571013 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr17:36571014-36571949 and GRCh37_chr17:36571950-36572884 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36574173-36574722 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36574723-36575272 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36575776-36576704 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36577634-36578562 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36580149-36580794 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36584872-36585780 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36585781-36586688 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36592213-36592713 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36597014-36597516 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36605280-36606221 Neighboring gene uncharacterized LOC101929494 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36607163-36608104 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:36614287-36614452 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36616590-36617218 Neighboring gene Sharpr-MPRA regulatory region 7659 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36621073-36621864 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36625516-36626152 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36628374-36628874 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36640731-36641252 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:36649991-36650490 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:36649489-36649990 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36655308-36655834 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36655835-36656359 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36665002-36665819 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36665820-36666636 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:36706969-36707178 Neighboring gene SRC kinase signaling inhibitor 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36717306-36717859 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36718413-36718965 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36718966-36719517 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36719518-36720070 Neighboring gene uncharacterized LOC105371761 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36720624-36721176 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36721177-36721728 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36722271-36722779 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36734639-36735366 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36735367-36736094 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36748159-36748740 Neighboring gene uncharacterized LOC124903992 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36749033-36749534 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36749535-36750034

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification and characterization of human ARHGAP23 gene in silico. Katoh M, et al. Int J Oncol, 2004 Aug. PMID 15254754
  2. GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. Pharoah PD, et al. Nat Genet, 2013 Apr. PMID 23535730, Free PMC Article
  3. 14-3-3 proteins sequester a pool of soluble TRIM32 ubiquitin ligase to repress autoubiquitylation and cytoplasmic body formation. Ichimura T, et al. J Cell Sci, 2013 May 1. PMID 23444366
  4. Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes. Choy KW, et al. Physiol Genomics, 2006 Mar 13. PMID 16368877
  5. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. Zody MC, et al. Nature, 2006 Apr 20. PMID 16625196, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1501

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activator activity TAS
Traceable Author Statement
more info
  
Process Evidence Code Pubs
involved_in regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 

General protein information

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Preferred Names
rho GTPase-activating protein 23
Names
rho-type GTPase-activating protein 23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199417.2 → NP_001186346.1  rho GTPase-activating protein 23

    See identical proteins and their annotated locations for NP_001186346.1

    Status: VALIDATED

    Source sequence(s)
    AC244153
    Consensus CDS
    CCDS56027.1
    UniProtKB/Swiss-Prot
    Q9P227
    UniProtKB/TrEMBL
    A0A2X0SFL7
    Related
    ENSP00000481862.1, ENST00000622683.5
    Conserved Domains (4) summary
    cd00992
    Location:41 → 151
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:902 → 1097
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cd01253
    Location:690 → 810
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    pfam00169
    Location:689 → 808
    PH; PH domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    38419275..38512385
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006721991.2 → XP_006722054.1  rho GTPase-activating protein 23 isoform X2

    See identical proteins and their annotated locations for XP_006722054.1

    UniProtKB/TrEMBL
    A0A2X0SFL7, A0A9L9PXQ2
    Related
    ENSP00000516484.1, ENST00000633445.2
    Conserved Domains (4) summary
    cd00992
    Location:23 → 133
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:884 → 1079
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cd01253
    Location:672 → 792
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    pfam00169
    Location:671 → 790
    PH; PH domain

  2. XM_006721993.4 → XP_006722056.1  rho GTPase-activating protein 23 isoform X6

    See identical proteins and their annotated locations for XP_006722056.1

    Conserved Domains (4) summary
    cd00992
    Location:41 → 151
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:902 → 1097
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cd01253
    Location:690 → 810
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    pfam00169
    Location:689 → 808
    PH; PH domain

  3. XM_006721992.4 → XP_006722055.1  rho GTPase-activating protein 23 isoform X3

    See identical proteins and their annotated locations for XP_006722055.1

    UniProtKB/TrEMBL
    A0A2X0SFL7
    Conserved Domains (3) summary
    cd00992
    Location:41 → 151
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:819 → 1014
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cl17171
    Location:590 → 727
    PH-like; Pleckstrin homology-like domain

  4. XM_011525076.3 → XP_011523378.1  rho GTPase-activating protein 23 isoform X7

    See identical proteins and their annotated locations for XP_011523378.1

    Related
    ENSP00000482992.1, ENST00000620417.4
    Conserved Domains (4) summary
    cd00992
    Location:41 → 151
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:902 → 1097
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cd01253
    Location:690 → 810
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    pfam00169
    Location:689 → 808
    PH; PH domain

  5. XM_011525077.3 → XP_011523379.1  rho GTPase-activating protein 23 isoform X8

    See identical proteins and their annotated locations for XP_011523379.1

    Conserved Domains (4) summary
    cd00992
    Location:41 → 151
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:902 → 1097
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cd01253
    Location:690 → 810
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    pfam00169
    Location:689 → 808
    PH; PH domain

  6. XM_047436477.1 → XP_047292433.1  rho GTPase-activating protein 23 isoform X9

  7. XM_011525074.3 → XP_011523376.1  rho GTPase-activating protein 23 isoform X4

    See identical proteins and their annotated locations for XP_011523376.1

    UniProtKB/TrEMBL
    A0A2X0SFL7
    Related
    ENSP00000516485.1, ENST00000616767.2
    Conserved Domains (4) summary
    PHA03247
    Location:77 → 499
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:4 → 57
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:808 → 1003
    RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
    cd01253
    Location:596 → 716
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain

  8. XM_011525073.2 → XP_011523375.1  rho GTPase-activating protein 23 isoform X1

    See identical proteins and their annotated locations for XP_011523375.1

    UniProtKB/TrEMBL
    A0A2X0SFL7
    Conserved Domains (4) summary
    cd00992
    Location:26 → 136
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:887 → 1082
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cd01253
    Location:675 → 795
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    pfam00169
    Location:674 → 793
    PH; PH domain

  9. XM_011525075.3 → XP_011523377.1  rho GTPase-activating protein 23 isoform X5

    See identical proteins and their annotated locations for XP_011523377.1

    UniProtKB/TrEMBL
    A0A2X0SFL7
    Conserved Domains (3) summary
    cd04395
    Location:696 → 891
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cd01253
    Location:484 → 604
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    pfam00169
    Location:483 → 602
    PH; PH domain

RNA

  1. XR_429909.4 RNA Sequence

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187614.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    2454590..2547687
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054329303.1 → XP_054185278.1  rho GTPase-activating protein 23 isoform X2

    UniProtKB/TrEMBL
    A0A9L9PXQ2

  2. XM_054329307.1 → XP_054185282.1  rho GTPase-activating protein 23 isoform X6

  3. XM_054329304.1 → XP_054185279.1  rho GTPase-activating protein 23 isoform X3

  4. XM_054329308.1 → XP_054185283.1  rho GTPase-activating protein 23 isoform X7

  5. XM_054329310.1 → XP_054185285.1  rho GTPase-activating protein 23 isoform X9

  6. XM_054329309.1 → XP_054185284.1  rho GTPase-activating protein 23 isoform X8

  7. XM_054329305.1 → XP_054185280.1  rho GTPase-activating protein 23 isoform X4

  8. XM_054329302.1 → XP_054185277.1  rho GTPase-activating protein 23 isoform X1

  9. XM_054329306.1 → XP_054185281.1  rho GTPase-activating protein 23 isoform X5

RNA

  1. XR_008485634.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    39282325..39375417
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054316779.1 → XP_054172754.1  rho GTPase-activating protein 23 isoform X2

    UniProtKB/TrEMBL
    A0A9L9PXQ2

  2. XM_054316783.1 → XP_054172758.1  rho GTPase-activating protein 23 isoform X6

  3. XM_054316780.1 → XP_054172755.1  rho GTPase-activating protein 23 isoform X3

  4. XM_054316784.1 → XP_054172759.1  rho GTPase-activating protein 23 isoform X7

  5. XM_054316786.1 → XP_054172761.1  rho GTPase-activating protein 23 isoform X9

  6. XM_054316785.1 → XP_054172760.1  rho GTPase-activating protein 23 isoform X8

  7. XM_054316781.1 → XP_054172756.1  rho GTPase-activating protein 23 isoform X4

  8. XM_054316778.1 → XP_054172753.1  rho GTPase-activating protein 23 isoform X1

  9. XM_054316782.1 → XP_054172757.1  rho GTPase-activating protein 23 isoform X5

RNA

  1. XR_008484866.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_020876.1: Suppressed sequence

    Description
    NM_020876.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate, and the CDS is partial on the 5' end.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9P227.2 GenPept UniProtKB/Swiss-Prot:Q9P227

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