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DPP10 dipeptidyl peptidase like 10 [ Homo sapiens (human) ]

Gene ID: 57628, updated on 2-Nov-2024

Summary

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Official Symbol
DPP10provided by HGNC
Official Full Name
dipeptidyl peptidase like 10provided by HGNC
Primary source
HGNC:HGNC:20823
See related
Ensembl:ENSG00000175497 MIM:608209; AllianceGenome:HGNC:20823
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DPL2; DPPY; DPRP3; DPRP-3
Summary
This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Mutations in this gene have been associated with asthma. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 7.5), adrenal (RPKM 2.9) and 2 other tissues See more
Orthologs
mouse all
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Genomic context

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See DPP10 in Genome Data Viewer
Location:
2q14.1
Exon count:
38
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (114442641..115845780)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (114868138..116270550)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (115200218..116603356)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124906175 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:115170872-115171372 Neighboring gene uncharacterized LOC124907877 Neighboring gene RNA, U2 small nuclear 41, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr2:115312469-115312655 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:115409386-115410190 Neighboring gene NANOG hESC enhancer GRCh37_chr2:115527347-115527874 Neighboring gene NANOG hESC enhancer GRCh37_chr2:115578660-115579193 Neighboring gene DPP10 antisense RNA 3 Neighboring gene uncharacterized LOC105373575 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:115843289-115844136 Neighboring gene uncharacterized LOC105373574 Neighboring gene uncharacterized LOC107985937 Neighboring gene DPP10 antisense RNA 1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:116185039-116185693 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:116232976-116233161 Neighboring gene ribosomal protein SA pseudogene 23 Neighboring gene uncharacterized LOC105373572 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:116851897-116852396 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:116900117-116900937 Neighboring gene uncharacterized LOC105373576 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:117248055-117249254 Neighboring gene MT-CYB pseudogene 39

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Dipeptidyl peptidase 10 (DPP10(789)): a voltage gated potassium channel associated protein is abnormally expressed in Alzheimer's and other neurodegenerative diseases. Chen T, et al. Biomed Res Int, 2014. PMID 25025038, Free PMC Article
  2. Dipeptidyl peptidase IV gene family. The DPIV family. Chen T, et al. Adv Exp Med Biol, 2003. PMID 12675227
  3. Crystallization and preliminary X-ray diffraction analysis of human dipeptidyl peptidase 10 (DPPY), a component of voltage-gated potassium channels. Bezerra GA, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2012 Feb 1. PMID 22298003, Free PMC Article
  4. Molecular characterization of a novel dipeptidyl peptidase like 2-short form (DPL2-s) that is highly expressed in the brain and lacks dipeptidyl peptidase activity. Chen T, et al. Biochim Biophys Acta, 2006 Jan. PMID 16290253
  5. Dipeptidyl-peptidase 10 as a genetic biomarker for the aspirin-exacerbated respiratory disease phenotype. Kim SH, et al. Ann Allergy Asthma Immunol, 2015 Mar. PMID 25592153

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Omega-3 Fatty Acids Interact with DPP10 Region Genotype in Association with Childhood Atopy.
    Title: Omega-3 Fatty Acids Interact with DPP10 Region Genotype in Association with Childhood Atopy.
  2. Contribution of dipeptidyl peptidase 10 to airway dysfunction in patients with NSAID-exacerbated respiratory disease.
    Title: Contribution of dipeptidyl peptidase 10 to airway dysfunction in patients with NSAID-exacerbated respiratory disease.
  3. increased ventricular DPP10 expression in heart failure might promote arrhythmias by decreasing peak Na(+) current, while increasing window Na(+) current and channel re-openings due to accelerated recovery from inactivation
    Title: DPP10 is a new regulator of Nav1.5 channels in human heart.
  4. SNP rs11693320 associated with pulmonary function when incorporating an interaction with docosahexaenoic acid
    Title: Omega-3 Fatty Acids and Genome-Wide Interaction Analyses Reveal DPP10-Pulmonary Function Association.
  5. These results show that a Dpp10 point mutation leads to increased airway responsiveness following allergen challenge.
    Title: Manipulation of dipeptidylpeptidase 10 in mouse and human in vivo and in vitro models indicates a protective role in asthma.
  6. The DPP10 duplication is likely a benign CNV polymorphism enriched in Southern Chinese with a population frequency of ~1%.
    Title: Use of clinical chromosomal microarray in Chinese patients with autism spectrum disorder-implications of a copy number variation involving DPP10.
  7. The stoichiometry of the Kv4.2-DPP10 complex was variable depending on the relative expression level of each subunit, with a preference for 4:2 stoichiometry
    Title: Kv4.2 and accessory dipeptidyl peptidase-like protein 10 (DPP10) subunit preferentially form a 4:2 (Kv4.2:DPP10) channel complex.
  8. the interaction of DPP10a, expressed in human atrium, with Kv4.3 channels generates a sustained current component of Ito, which may affect late repolarization phase of atrial action potentials.
    Title: Interaction of DPP10a with Kv4.3 channel complex results in a sustained current component of human transient outward current Ito.
  9. study suggests a genetic contribution of DPP10 rs17048175 in eosinophilic inflammation induction in the airways and to aspirin-exacerbated respiratory disease susceptibility
    Title: Dipeptidyl-peptidase 10 as a genetic biomarker for the aspirin-exacerbated respiratory disease phenotype.
  10. Our results suggest that DPP10(789) is involved in the pathology of AD and other neurodegenerative diseases.
    Title: Dipeptidyl peptidase 10 (DPP10(789)): a voltage gated potassium channel associated protein is abnormally expressed in Alzheimer's and other neurodegenerative diseases.
Submit: New GeneRIF Correction See all GeneRIFs (27)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide meta-analysis of systolic blood pressure in children with sickle cell disease.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog
Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder.
EBI GWAS Catalog

Variation

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See Variation Viewer (GRCh37.p13)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT enables dipeptidyl-peptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables potassium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables potassium channel regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein localization to plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of potassium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated potassium channel complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
inactive dipeptidyl peptidase 10
Names
DPP X
dipeptidyl peptidase 10
dipeptidyl peptidase IV-related protein 3
dipeptidyl peptidase X
dipeptidyl peptidase-like protein 2
dipeptidyl-peptidase 10 (inactive)
dipeptidyl-peptidase 10 (non-functional)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004360.5 → NP_001004360.3  inactive dipeptidyl peptidase 10 isoform short

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' exon, as compared to variant 3. The resulting isoform (short, also referred to as DPL2-s and d) has a shorter and distinct N-terminus when compared to isoform c.
    Source sequence(s)
    AC016721, AC017040, AC066593, AC067947, AC105422
    Consensus CDS
    CCDS33278.1
    UniProtKB/TrEMBL
    Q0GLB7
    Related
    ENSP00000309066.8, ENST00000310323.12
    Conserved Domains (2) summary
    pfam00326
    Location:573 → 775
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:126 → 492
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

  2. NM_001178034.1 → NP_001171505.1  inactive dipeptidyl peptidase 10 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC016721, AC066593, DQ857322
    Consensus CDS
    CCDS54388.1
    UniProtKB/TrEMBL
    Q0GLB7
    Related
    ENSP00000376855.2, ENST00000393147.6
    Conserved Domains (2) summary
    pfam00326
    Location:584 → 786
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:137 → 503
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

  3. NM_001178036.3 → NP_001171507.2  inactive dipeptidyl peptidase 10 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has an alternate 5' exon, as compared to variant 3. The resulting isoform (a) has a shorter and distinct N-terminus when compared to isoform c.
    Source sequence(s)
    AC010885, AC016721, AC017040, AC067947, AC105422
    Consensus CDS
    CCDS54389.1
    UniProtKB/TrEMBL
    Q0GLB7
    Related
    ENSP00000387038.1, ENST00000409163.5
    Conserved Domains (2) summary
    pfam00326
    Location:530 → 732
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:83 → 449
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

  4. NM_001178037.3 → NP_001171508.2  inactive dipeptidyl peptidase 10 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has an alternate 5' exon, as compared to variant 3. The resulting isoform (b) has a shorter and distinct N-terminus when compared to isoform c.
    Source sequence(s)
    AC016721, AC017040, AC067947, AC093610, AC105422
    UniProtKB/TrEMBL
    Q0GLB9
    Conserved Domains (2) summary
    pfam00326
    Location:576 → 778
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:129 → 495
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

  5. NM_001321905.3 → NP_001308834.2  inactive dipeptidyl peptidase 10 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC010885, AC012071, AC016721, AC017040, AC067947, AC105422
    UniProtKB/TrEMBL
    B2RCJ8
    Conserved Domains (2) summary
    pfam00326
    Location:597 → 799
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:150 → 516
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

  6. NM_001321906.2 → NP_001308835.2  inactive dipeptidyl peptidase 10 isoform short

    Status: VALIDATED

    Source sequence(s)
    AC016721, AC066593, BM974067, DQ857322
    Consensus CDS
    CCDS33278.1
    UniProtKB/TrEMBL
    Q0GLB7
    Conserved Domains (2) summary
    pfam00326
    Location:573 → 775
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:126 → 492
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

  7. NM_001321907.3 → NP_001308836.2  inactive dipeptidyl peptidase 10 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC010885, AC016721, AC017040, AC067947, AC105422
    UniProtKB/TrEMBL
    B2RCJ8
    Conserved Domains (2) summary
    pfam00326
    Location:567 → 769
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:133 → 486
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

  8. NM_001321908.3 → NP_001308837.2  inactive dipeptidyl peptidase 10 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC010885, AC016721, AC017040, AC067947, AC105422
    UniProtKB/TrEMBL
    Q0GLB7
    Conserved Domains (2) summary
    pfam00326
    Location:550 → 752
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:103 → 469
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

  9. NM_001321909.3 → NP_001308838.2  inactive dipeptidyl peptidase 10 isoform g

    Status: VALIDATED

    Source sequence(s)
    AC016721, AC017040, AC066593, AC067947, AC105422
    UniProtKB/TrEMBL
    Q0GLB7
    Conserved Domains (2) summary
    pfam00326
    Location:541 → 743
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:94 → 460
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

  10. NM_001321910.3 → NP_001308839.2  inactive dipeptidyl peptidase 10 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC010885, AC012071, AC016721, AC017040, AC067947, AC105422
    Consensus CDS
    CCDS54389.1
    UniProtKB/TrEMBL
    Q0GLB7
    Conserved Domains (2) summary
    pfam00326
    Location:530 → 732
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:83 → 449
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

  11. NM_001321911.3 → NP_001308840.2  inactive dipeptidyl peptidase 10 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC010885, AC016721, AC017040, AC067947, AC105422
    Consensus CDS
    CCDS54389.1
    UniProtKB/TrEMBL
    Q0GLB7
    Conserved Domains (2) summary
    pfam00326
    Location:530 → 732
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:83 → 449
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

  12. NM_001321912.3 → NP_001308841.2  inactive dipeptidyl peptidase 10 isoform h

    Status: VALIDATED

    Source sequence(s)
    AC010885, AC016721, AC017040, AC067947, AC105422
    UniProtKB/TrEMBL
    Q0GLB7
    Conserved Domains (2) summary
    pfam00930
    Location:83 → 449
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    cl21494
    Location:530 → 677
    Abhydrolase; alpha/beta hydrolases

  13. NM_001321913.3 → NP_001308842.2  inactive dipeptidyl peptidase 10 isoform i

    Status: VALIDATED

    Source sequence(s)
    AC010885, AC016721, AC017040, AC067947, AC105422
    Conserved Domains (2) summary
    pfam00326
    Location:326 → 528
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:1 → 245
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

  14. NM_001321914.2 → NP_001308843.2  inactive dipeptidyl peptidase 10 isoform i

    Status: VALIDATED

    Source sequence(s)
    AC016721, AC066593, BM974067, DQ857322
    Conserved Domains (2) summary
    pfam00326
    Location:326 → 528
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:1 → 245
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

  15. NM_001399849.1 → NP_001386778.1  inactive dipeptidyl peptidase 10 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC010885, AC016721, AC017040, AC067947, AC093610, AC105422
    Consensus CDS
    CCDS54389.1

  16. NM_001399850.1 → NP_001386779.1  inactive dipeptidyl peptidase 10 isoform i

    Status: VALIDATED

    Source sequence(s)
    AC016721, AC017040, AC066593, AC067947, AC105422

  17. NM_001399851.1 → NP_001386780.1  inactive dipeptidyl peptidase 10 isoform j

    Status: VALIDATED

    Source sequence(s)
    AC016721, AC017040, AC066593, AC067947, AC105422

  18. NM_020868.6 → NP_065919.3  inactive dipeptidyl peptidase 10 isoform long

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) has an alternate 5' exon, as compared to variant 3. The resulting isoform (long, also referred to as DPL2-l) is slightly shorter and has a distinct N-terminus when compared to isoform c.
    Source sequence(s)
    AC010885, AC016721, AC017040, AC067947, AC105422
    Consensus CDS
    CCDS46400.1
    UniProtKB/Swiss-Prot
    A8K1Q2, J3KPP2, J3KQ46, Q0GLB8, Q53QT3, Q53S86, Q53SL8, Q53SS4, Q6TTV4, Q86YR9, Q8N608, Q9P236
    UniProtKB/TrEMBL
    B2RCJ8
    Related
    ENSP00000386565.1, ENST00000410059.6
    Conserved Domains (2) summary
    pfam00326
    Location:580 → 782
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:133 → 499
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    114442641..115845780
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047445202.1 → XP_047301158.1  inactive dipeptidyl peptidase 10 isoform X1

  2. XM_047445203.1 → XP_047301159.1  inactive dipeptidyl peptidase 10 isoform X2

  3. XM_047445207.1 → XP_047301163.1  inactive dipeptidyl peptidase 10 isoform X4

  4. XM_047445205.1 → XP_047301161.1  inactive dipeptidyl peptidase 10 isoform X4

  5. XM_017004566.2 → XP_016860055.1  inactive dipeptidyl peptidase 10 isoform X3

    UniProtKB/TrEMBL
    Q0GLB7

  6. XM_047445204.1 → XP_047301160.1  inactive dipeptidyl peptidase 10 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    114868138..116270550
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054343190.1 → XP_054199165.1  inactive dipeptidyl peptidase 10 isoform X1

  2. XM_054343191.1 → XP_054199166.1  inactive dipeptidyl peptidase 10 isoform X2

  3. XM_054343193.1 → XP_054199168.1  inactive dipeptidyl peptidase 10 isoform X5

  4. XM_054343196.1 → XP_054199171.1  inactive dipeptidyl peptidase 10 isoform X4

  5. XM_054343195.1 → XP_054199170.1  inactive dipeptidyl peptidase 10 isoform X4

  6. XM_054343192.1 → XP_054199167.1  inactive dipeptidyl peptidase 10 isoform X3

  7. XM_054343194.1 → XP_054199169.1  inactive dipeptidyl peptidase 10 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N608.2 GenPept UniProtKB/Swiss-Prot:Q8N608

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