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USP35 ubiquitin specific peptidase 35 [ Homo sapiens (human) ]

Gene ID: 57558, updated on 14-Nov-2024

Summary

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Official Symbol
USP35provided by HGNC
Official Full Name
ubiquitin specific peptidase 35provided by HGNC
Primary source
HGNC:HGNC:20061
See related
Ensembl:ENSG00000118369 MIM:620959; AllianceGenome:HGNC:20061
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the peptidase C19 family of ubiquitin-specific proteases. These deubiquitinating enzymes (DUBs) catalyze the removal of ubiquitin proteins from other proteins. The encoded protein associates with polarized mitochondria and has been shown to inhibit NF-kappa B activation and delay PARK2-mediated degradation of mitochondria. Expression of this gene is upregulated by the let-7a microRNA and reduced expression has been observed in human tumor tissues. [provided by RefSeq, Jul 2017]
Expression
Ubiquitous expression in adrenal (RPKM 3.3), brain (RPKM 2.1) and 25 other tissues See more
Orthologs
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Genomic context

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See USP35 in Genome Data Viewer
Location:
11q14.1
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (78188919..78237219)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (78122182..78166945)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (77899965..77926278)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ALG8 alpha-1,3-glucosyltransferase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5314 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5315 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5316 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:77851405-77852115 Neighboring gene RNA, U6 small nuclear 126, pseudogene Neighboring gene KCTD21 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:77884885-77885386 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:77890493-77890992 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3808 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3809 Neighboring gene potassium channel tetramerization domain containing 21 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:77921405-77922031 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3810 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5317 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5318 Neighboring gene GRB2 associated binding protein 2 Neighboring gene Sharpr-MPRA regulatory region 2371 Neighboring gene uncharacterized LOC105369402 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5319 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5320 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:78076162-78077074 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:78081224-78082174 Neighboring gene zinc finger protein 75C, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. USP35 promotes hepatocellular carcinoma progression by protecting PKM2 from ubiquitination‑mediated degradation. Lv T, et al. Int J Oncol, 2023 Oct. PMID 37594129, Free PMC Article
  2. The deubiquitylating enzyme USP35 restricts regulated cell death to promote survival of renal clear cell carcinoma. Wang S, et al. Cell Death Differ, 2023 Jul. PMID 37173391, Free PMC Article
  3. Expansion of DUB functionality generated by alternative isoforms - USP35, a case study. Leznicki P, et al. J Cell Sci, 2018 May 16. PMID 29685892, Free PMC Article
  4. Deubiquitinase USP35 modulates ferroptosis in lung cancer via targeting ferroportin. Tang Z, et al. Clin Transl Med, 2021 Apr. PMID 33931967, Free PMC Article
  5. Ubiquitin-specific Protease 35 Promotes Gastric Cancer Metastasis by Increasing the Stability of Snail1. Ma C, et al. Int J Biol Sci, 2024. PMID 38250150, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ubiquitin-specific Protease 35 Promotes Gastric Cancer Metastasis by Increasing the Stability of Snail1.
    Title: Ubiquitin-specific Protease 35 Promotes Gastric Cancer Metastasis by Increasing the Stability of Snail1.
  2. USP35 promotes hepatocellular carcinoma progression by protecting PKM2 from ubiquitination-mediated degradation.
    Title: USP35 promotes hepatocellular carcinoma progression by protecting PKM2 from ubiquitination‑mediated degradation.
  3. The deubiquitylating enzyme USP35 restricts regulated cell death to promote survival of renal clear cell carcinoma.
    Title: The deubiquitylating enzyme USP35 restricts regulated cell death to promote survival of renal clear cell carcinoma.
  4. USP35 mitigates endoplasmic reticulum stress-induced apoptosis by stabilizing RRBP1 in non-small cell lung cancer.
    Title: USP35 mitigates endoplasmic reticulum stress-induced apoptosis by stabilizing RRBP1 in non-small cell lung cancer.
  5. Deubiquitinase USP35 modulates ferroptosis in lung cancer via targeting ferroportin.
    Title: Deubiquitinase USP35 modulates ferroptosis in lung cancer via targeting ferroportin.
  6. Deubiquitinase USP35 restrains STING-mediated interferon signaling in ovarian cancer.
    Title: Deubiquitinase USP35 restrains STING-mediated interferon signaling in ovarian cancer.
  7. Regulation of survivin protein stability by USP35 is evolutionarily conserved.
    Title: Regulation of survivin protein stability by USP35 is evolutionarily conserved.
  8. USP35, regulated by estrogen and AKT, promotes breast tumorigenesis by stabilizing and enhancing transcriptional activity of estrogen receptor alpha.
    Title: USP35, regulated by estrogen and AKT, promotes breast tumorigenesis by stabilizing and enhancing transcriptional activity of estrogen receptor α.
  9. Genome-wide suppressor screen identifies USP35/USP38 as therapeutic candidates for ciliopathies.
    Title: Genome-wide suppressor screen identifies USP35/USP38 as therapeutic candidates for ciliopathies.
  10. Two different USP35 isoforms that localise to different intracellular compartments and have distinct functions.
    Title: Expansion of DUB functionality generated by alternative isoforms - USP35, a case study.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein deubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein stability IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase 35
Names
deubiquitinating enzyme 35
ubiquitin specific protease 35
ubiquitin thioesterase 35
ubiquitin thiolesterase 35
ubiquitin-specific-processing protease 35
NP_065849.1
XP_011543489.1
XP_011543490.1
XP_047283288.1
XP_047283290.1
XP_047283291.1
XP_054225458.1
XP_054225459.1
XP_054225460.1
XP_054225461.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020798.4 → NP_065849.1  ubiquitin carboxyl-terminal hydrolase 35

    See identical proteins and their annotated locations for NP_065849.1

    Status: REVIEWED

    Source sequence(s)
    AB037793, AI263341, AJ586137, AK056231, AP002985, CN287538, DB095282
    Consensus CDS
    CCDS41693.1
    UniProtKB/Swiss-Prot
    Q9P2H5
    Related
    ENSP00000431876.1, ENST00000529308.6
    Conserved Domains (2) summary
    cl02553
    Location:442 → 924
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:441 → 923
    UCH; Ubiquitin carboxyl-terminal hydrolase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    78188919..78237219
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047427335.1 → XP_047283291.1  ubiquitin carboxyl-terminal hydrolase 35 isoform X1

    UniProtKB/Swiss-Prot
    Q9P2H5

  2. XM_047427334.1 → XP_047283290.1  ubiquitin carboxyl-terminal hydrolase 35 isoform X1

    UniProtKB/Swiss-Prot
    Q9P2H5

  3. XM_047427332.1 → XP_047283288.1  ubiquitin carboxyl-terminal hydrolase 35 isoform X1

    UniProtKB/Swiss-Prot
    Q9P2H5

  4. XM_011545188.3 → XP_011543490.1  ubiquitin carboxyl-terminal hydrolase 35 isoform X2

    See identical proteins and their annotated locations for XP_011543490.1

    UniProtKB/Swiss-Prot
    Q9P2H5
    Related
    ENSP00000434942.1, ENST00000526425.1
    Conserved Domains (2) summary
    cl02553
    Location:173 → 655
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:172 → 654
    UCH; Ubiquitin carboxyl-terminal hydrolase

  5. XM_011545187.3 → XP_011543489.1  ubiquitin carboxyl-terminal hydrolase 35 isoform X2

    See identical proteins and their annotated locations for XP_011543489.1

    UniProtKB/Swiss-Prot
    Q9P2H5
    Conserved Domains (2) summary
    cl02553
    Location:173 → 655
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:172 → 654
    UCH; Ubiquitin carboxyl-terminal hydrolase

RNA

  1. XR_001747930.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    78122182..78166945
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054369484.1 → XP_054225459.1  ubiquitin carboxyl-terminal hydrolase 35 isoform X1

  2. XM_054369483.1 → XP_054225458.1  ubiquitin carboxyl-terminal hydrolase 35 isoform X1

  3. XM_054369486.1 → XP_054225461.1  ubiquitin carboxyl-terminal hydrolase 35 isoform X2

  4. XM_054369485.1 → XP_054225460.1  ubiquitin carboxyl-terminal hydrolase 35 isoform X2

RNA

  1. XR_008488421.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9P2H5.3 GenPept UniProtKB/Swiss-Prot:Q9P2H5

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