MTA3 metastasis associated 1 family member 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MTA3provided by HGNC
Official Full Name: metastasis associated 1 family member 3provided by HGNC
Primary source: HGNC:HGNC:23784
See related: Ensembl:ENSG00000057935 MIM:609050; AllianceGenome:HGNC:23784
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: Predicted to enable histone deacetylase binding activity; transcription coactivator activity; and transcription corepressor activity. Involved in chromatin remodeling and negative regulation of DNA-templated transcription. Located in nucleoplasm. Part of NuRD complex. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in brain (RPKM 6.3), ovary (RPKM 5.7) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2p21

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (42494110..42756946)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (42499549..42762201)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (42721250..42984086)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of MTA2 and MTA3 induces mesendoderm specification of human embryonic stem cells.
Title: Inhibition of MTA2 and MTA3 induces mesendoderm specification of human embryonic stem cells.
LncRNA HCG11 suppresses the growth of glioma by cooperating with the miR-4425/MTA3 axis.
Title: Long non-coding RNA HCG11 suppresses the growth of glioma by cooperating with the miR-4425/MTA3 axis.
The circ_0021093/miR-766-3p/MTA3 regulatory axis may be an effective therapeutic target for HCC.
Title: Overexpression of circ_0021093 circular RNA forecasts an unfavorable prognosis and facilitates cell progression by targeting the miR-766-3p/MTA3 pathway in hepatocellular carcinoma.
associated with Infantile hypertrophic pyloric stenosis risk
Title: Genome-wide meta-analysis identifies BARX1 and EML4-MTA3 as new loci associated with infantile hypertrophic pyloric stenosis.
The authors demonstrate that the SIX3/LSD1/NuRD(MTA3) complex inhibits carcinogenesis in breast cancer cells and suppresses metastasis in breast cancer.
Title: The Homeotic Protein SIX3 Suppresses Carcinogenesis and Metastasis through Recruiting the LSD1/NuRD(MTA3) Complex.
Results show that metastasis associated 1 family member 3 (MTA3) level was decreased in colorectal cancer and significantly correlated with tumor cell invasion and metastasis, and that MTA3 might serve as a potential marker of tumor recurrence and prognosis of colorectal cancer.
Title: Metastasis-associated protein 3 in colorectal cancer determines tumor recurrence and prognosis.
MTA3 is an oncogene of HCC, predicts poor prognosis of HCC, and may be a future marker of HCC treatment.
Title: Overexpression of the metastasis-associated gene MTA3 correlates with tumor progression and poor prognosis in hepatocellular carcinoma.
As a master regulator, MTA3 governs the target selection for nucleosome remodeling and histone deacetylation and functions as a transcriptional repressor. MTA3 dysregulation is associated with tumor progression, invasion, and metastasis in various cancers. MTA is also a key regulator of E-cadherin expression and epithelial-to-mesenchymal transition.
Title: Corepressor metastasis-associated protein 3 modulates epithelial-to-mesenchymal transition and metastasis.
MTA3 depletion induced cell cycle arrest at the G1/S boundary. Western blotting analysis revealed that the knockdown of MTA3 decreased the protein levels of cyclin A, cyclin D1 and p-Rb. These results indicate that MTA3 plays an important role in NSCLC progression
Title: Overexpression of MTA3 Correlates with Tumor Progression in Non-Small Cell Lung Cancer.
Our results demonstrated that MTA3 overexpression contributes to colorectal cancer carcinogenesis, progression, and chemoresistance. MTA3 could serve as a potential therapeutic target in colorectal cancer
Title: MTA3 regulates malignant progression of colorectal cancer through Wnt signaling pathway.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH65437 (e-PCR)
- UniSTS:54832

D8S2279 (e-PCR)
- UniSTS:473907

D8S2282 (e-PCR)
- UniSTS:473910

BCD1971 (e-PCR)
- UniSTS:72626

RH94235 (e-PCR)
- UniSTS:90828

RH103421 (e-PCR)
- UniSTS:97746

SHGC-64953 (e-PCR)
- UniSTS:71419

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables histone deacetylase binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G2/M transition of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in granulosa cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of G2/M transition of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of granulosa cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell fate specification	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of stem cell differentiation	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of NuRD complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NuRD complex	IDA Inferred from Direct Assay more info	PubMed
part_of NuRD complex	NAS Non-traceable Author Statement more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: metastasis-associated protein MTA3

Names: metastasis associated gene family, member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001282755.2 → NP_001269684.1 metastasis-associated protein MTA3 isoform a

See identical proteins and their annotated locations for NP_001269684.1

Status: VALIDATED

Source sequence(s)

AB033092, AC025750, AK127245, AW292870, DA239202

Consensus CDS

CCDS62900.1

UniProtKB/TrEMBL

E7EV10, F6RRE2

Related

ENSP00000383973.1, ENST00000405592.5

Conserved Domains (5) summary

cd11661
Location:214 → 259

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:319 → 368

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

pfam01448
Location:94 → 145

ELM2; ELM2 domain

pfam17226
Location:404 → 480

MTA_R1; MTA R1 domain

cl02608
Location:2 → 114

BAH; or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in ...
NM_001282756.2 → NP_001269685.1 metastasis-associated protein MTA3 isoform a

See identical proteins and their annotated locations for NP_001269685.1

Status: VALIDATED

Source sequence(s)

AB033092, AW292870

Consensus CDS

CCDS62900.1

UniProtKB/TrEMBL

E7EV10, F6RRE2

Related

ENSP00000384249.1, ENST00000406652.5

Conserved Domains (5) summary

cd11661
Location:214 → 259

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:319 → 368

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

pfam01448
Location:94 → 145

ELM2; ELM2 domain

pfam17226
Location:404 → 480

MTA_R1; MTA R1 domain

cl02608
Location:2 → 114

BAH; or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in ...
NM_001330442.2 → NP_001317371.1 metastasis-associated protein MTA3 isoform c

Status: VALIDATED

Description

Transcript Variant: This variant (4) encodes the longest isoform (c).

Source sequence(s)

AC025750, AC074375, AC098824

Consensus CDS

CCDS82441.1

UniProtKB/Swiss-Prot

Q9BTC8, Q9NSP2, Q9ULF4

UniProtKB/TrEMBL

E7EV10

Related

ENSP00000385823.1, ENST00000405094.2

Conserved Domains (5) summary

cd11661
Location:270 → 315

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:376 → 425

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd04709
Location:3 → 170

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

pfam01448
Location:150 → 201

ELM2; ELM2 domain

pfam17226
Location:461 → 537

MTA_R1; MTA R1 domain
NM_001330443.2 → NP_001317372.1 metastasis-associated protein MTA3 isoform d

Status: VALIDATED

Source sequence(s)

AC025750, AC074375, AC098824

UniProtKB/TrEMBL

E7EV10

Related

ENSP00000386763.1, ENST00000409019.5

Conserved Domains (5) summary

cd11661
Location:270 → 315

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:375 → 424

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd04709
Location:3 → 170

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

pfam01448
Location:150 → 201

ELM2; ELM2 domain

pfam17226
Location:460 → 536

MTA_R1; MTA R1 domain
NM_001330444.2 → NP_001317373.1 metastasis-associated protein MTA3 isoform e

Status: VALIDATED

Source sequence(s)

AC025750, AC074375, AC098824

UniProtKB/TrEMBL

E7EV10

Conserved Domains (5) summary

smart00401
Location:312 → 361

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd04709
Location:3 → 170

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

pfam01448
Location:150 → 201

ELM2; ELM2 domain

pfam17226
Location:397 → 473

MTA_R1; MTA R1 domain

cl21498
Location:234 → 252

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
NM_020744.4 → NP_065795.1 metastasis-associated protein MTA3 isoform b

See identical proteins and their annotated locations for NP_065795.1

Status: VALIDATED

Source sequence(s)

BC053631, CA447673, DB335600

Consensus CDS

CCDS46267.1

UniProtKB/TrEMBL

E7EV10

Related

ENSP00000385045.3, ENST00000407270.7

Conserved Domains (4) summary

cd11661
Location:270 → 315

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:376 → 425

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd04709
Location:3 → 170

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

pfam01448
Location:150 → 201

ELM2; ELM2 domain