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ZNF287 zinc finger protein 287 [ Homo sapiens (human) ]

Gene ID: 57336, updated on 2-Nov-2024

Summary

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Official Symbol
ZNF287provided by HGNC
Official Full Name
zinc finger protein 287provided by HGNC
Primary source
HGNC:HGNC:13502
See related
Ensembl:ENSG00000141040 AllianceGenome:HGNC:13502
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZSCAN45; ZKSCAN13
Summary
This gene encodes a member of the krueppel family of zinc finger proteins, suggesting a role as a transcription factor. Its specific function has not been determined. This gene is located near the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 1.8), thyroid (RPKM 1.4) and 23 other tissues See more
Orthologs
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Genomic context

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See ZNF287 in Genome Data Viewer
Location:
17p11.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (16546954..16569212, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (16449237..16471499, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (16450268..16472526, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903940 Neighboring gene uncharacterized LOC124903941 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11768 Neighboring gene uncharacterized LOC105371554 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:16471581-16472082 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:16472083-16472582 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11769 Neighboring gene zinc finger protein 624 Neighboring gene SRSF6 pseudogene 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:16556408-16556918 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8228 Neighboring gene uncharacterized LOC124903934

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Integrated analysis of whole-genome paired-end and mate-pair sequencing data for identifying genomic structural variations in multiple myeloma. Yang R, et al. Cancer Inform, 2014. PMID 25288879, Free PMC Article
  2. The biology of the mammalian Krüppel-like family of transcription factors. Dang DT, et al. Int J Biochem Cell Biol, 2000 Nov-Dec. PMID 11137451, Free PMC Article
  3. Zinc fingers: DNA binding and protein-protein interactions. Leon O, et al. Biol Res, 2000. PMID 11021307
  4. Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation. Kim SO, et al. Int J Mol Sci, 2021 Jul 15. PMID 34299191, Free PMC Article
  5. Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins. Yang J, et al. Cell Rep, 2023 Feb 28. PMID 36724073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC126536, MGC141923

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cytokine production IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 287
Names
zinc finger protein with KRAB and SCAN domains 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051652.1 RefSeqGene

    Range
    5009..27259
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001346167.2 → NP_001333096.1  zinc finger protein 287 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1-4 all encode the same isoform (a).
    Source sequence(s)
    AC127540
    Consensus CDS
    CCDS11179.2
    UniProtKB/Swiss-Prot
    Q6IAG1, Q9HBT7
    Conserved Domains (5) summary
    smart00349
    Location:170 → 227
    KRAB; krueppel associated box
    COG5048
    Location:422 → 755
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:364 → 419
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:426 → 446
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02605
    Location:46 → 144
    SCAN; SCAN oligomerization domain

  2. NM_001346168.2 → NP_001333097.1  zinc finger protein 287 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same isoform (a).
    Source sequence(s)
    AC127540
    Consensus CDS
    CCDS11179.2
    UniProtKB/Swiss-Prot
    Q6IAG1, Q9HBT7
    Conserved Domains (5) summary
    smart00349
    Location:170 → 227
    KRAB; krueppel associated box
    COG5048
    Location:422 → 755
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:364 → 419
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:426 → 446
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02605
    Location:46 → 144
    SCAN; SCAN oligomerization domain

  3. NM_001346169.2 → NP_001333098.1  zinc finger protein 287 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same isoform (a).
    Source sequence(s)
    AC127540
    Consensus CDS
    CCDS11179.2
    UniProtKB/Swiss-Prot
    Q6IAG1, Q9HBT7
    Related
    ENSP00000379168.1, ENST00000395824.5
    Conserved Domains (5) summary
    smart00349
    Location:170 → 227
    KRAB; krueppel associated box
    COG5048
    Location:422 → 755
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:364 → 419
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:426 → 446
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02605
    Location:46 → 144
    SCAN; SCAN oligomerization domain

  4. NM_001346170.1 → NP_001333099.1  zinc finger protein 287 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC127540

  5. NM_001346171.2 → NP_001333100.1  zinc finger protein 287 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AC127540

  6. NM_020653.4 → NP_065704.2  zinc finger protein 287 isoform a

    See identical proteins and their annotated locations for NP_065704.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same isoform (a).
    Source sequence(s)
    AC127540, BC057791, DA103127
    Consensus CDS
    CCDS11179.2
    UniProtKB/Swiss-Prot
    Q6IAG1, Q9HBT7
    Related
    ENSP00000379169.3, ENST00000395825.4
    Conserved Domains (5) summary
    smart00349
    Location:170 → 227
    KRAB; krueppel associated box
    COG5048
    Location:422 → 755
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:364 → 419
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:426 → 446
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02605
    Location:46 → 144
    SCAN; SCAN oligomerization domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    16546954..16569212 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    16449237..16471499 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9HBT7.2 GenPept UniProtKB/Swiss-Prot:Q9HBT7

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