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Aadac arylacetamide deacetylase [ Rattus norvegicus (Norway rat) ]

Gene ID: 57300, updated on 2-Nov-2024

Summary

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Official Symbol
Aadacprovided by RGD
Official Full Name
arylacetamide deacetylaseprovided by RGD
Primary source
RGD:631440
See related
EnsemblRapid:ENSRNOG00000013950 AllianceGenome:RGD:631440
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Aada
Summary
Predicted to enable deacetylase activity; serine hydrolase activity; and triacylglycerol lipase activity. Predicted to be involved in positive regulation of triglyceride catabolic process. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human AADAC (arylacetamide deacetylase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 358.6) and Kidney (RPKM 50.1) See more
Orthologs
human mouse all
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Genomic context

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See Aadac in Genome Data Viewer
Location:
2q31
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (146293449..146351061)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (144163436..144186086)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (150146234..150157480)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene AADACL2 family member 2 like 1 Neighboring gene uncharacterized LOC134485919 Neighboring gene arylacetamide deacetylase-like 2 Neighboring gene uncharacterized LOC134485920 Neighboring gene succinate receptor 1 Neighboring gene uncharacterized LOC102551458

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Arylacetamide deacetylase attenuates fatty-acid-induced triacylglycerol accumulation in rat hepatoma cells. Lo V, et al. J Lipid Res, 2010 Feb. PMID 19654421, Free PMC Article
  2. Human arylacetamide deacetylase is a principal enzyme in flutamide hydrolysis. Watanabe A, et al. Drug Metab Dispos, 2009 Jul. PMID 19339378
  3. Human carboxylesterases and their role in xenobiotic and endobiotic metabolism. Ross MK, et al. J Biochem Mol Toxicol, 2007. PMID 17936933
  4. Targeting proteins to the lumen of endoplasmic reticulum using N-terminal domains of 11beta-hydroxysteroid dehydrogenase and the 50-kDa esterase. Mziaut H, et al. J Biol Chem, 1999 May 14. PMID 10318829
  5. Determination of lumenal orientation of microsomal 50-kDa esterase/N-deacetylase. Ozols J. Biochemistry, 1998 Jul 14. PMID 9665742

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables carboxylic ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables deacetylase activity IEA
Inferred from Electronic Annotation
more info
  
enables deacetylase activity ISO
Inferred from Sequence Orthology
more info
  
enables deacetylase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables serine hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
enables triacylglycerol lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables triacylglycerol lipase activity IEA
Inferred from Electronic Annotation
more info
  
enables triacylglycerol lipase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of triglyceride catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of triglyceride catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of triglyceride catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
arylacetamide deacetylase
Names
arylacetamide deacetylase (esterase)
NP_065413.1
XP_063138494.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020538.1 → NP_065413.1  arylacetamide deacetylase

    See identical proteins and their annotated locations for NP_065413.1

    Status: PROVISIONAL

    Source sequence(s)
    AF182426
    UniProtKB/Swiss-Prot
    Q9QZH8
    UniProtKB/TrEMBL
    A0A9K3Y8C2, F7F0B9, Q5I0N0
    Related
    ENSRNOP00000018761.3, ENSRNOT00000018761.6
    Conserved Domains (2) summary
    COG0657
    Location:88 → 373
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam07859
    Location:106 → 373
    Abhydrolase_3; alpha/beta hydrolase fold

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    146293449..146351061
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063282424.1 → XP_063138494.1  arylacetamide deacetylase isoform X1

RNA

  1. XR_010063658.1 RNA Sequence

  2. XR_005500357.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QZH8.3 GenPept UniProtKB/Swiss-Prot:Q9QZH8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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